Faculty and Research

Arnold B. Rabson, MD
Professor and Director
Child Health Institute of NJ
Laura Gallagher Endowed Chair of Developmental Biology and Professor of Pediatrics, Pharmacology, Pathology and Laboratory Medicine

 

Child Health Institute of New Jersey, Room 3210

Phone: (732) 235-9523
Fax: (732) 235-8612
Email: rabsonab@rwjms.rutgers.edu


Laboratory
The Rabson laboratory studies the pathogenesis of human retroviral infections including the human T cell leukemia virus type 1-an important cause of human leukemias and inflammatory diseases, and the human immunodeficiency virus.  He also studies the roles of the NF-kB transcription regulators in the genetic basis of normal and malignant T cells, and the molecular basis of hematopoiesis and childhood leukemias.

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Davide Comoletti, DVM, PhD
Assistant Professor of Neuroscience and Cell Biology
Child Health Institute of NJ
Room 3275

Phone: (732) 235-9466
Fax: (732) 235-8612
Email: comoleda@rwjms.rutgers.edu

Laboratory
The Comoletti laboratory studies the structural and molecular basis of synapse formation and connectivity. We focus on the atomic structure and cellular functions of trans-synaptic adhesion molecules such as neuroligins, neurexins, LRRTMs, and their complexes. We use structural biology and molecular neuroscience tools to gain insights into how mutations of these proteins associate with autism and other common neurodevelopmental disorders.

Lab Web site

Lisa Denzin, PhD
Associate Professor of Pediatrics

Child Health Institute of NJ
Room 4272

Phone: (732) 235-9604
Fax: (732) 235-9534
Email: lisa.denzin@rutgers.edu

Laboratory
The Denzin laboratory studies antigen presentation and regulation of the immune response.  Her studies have shown the roles of variant MHC molecules in the regulation of autoimmune disorders including type 1 diabetes.  Her laboratory also studies the role of novel cell cycle regulatory proteins in leukemias.

Lab Web site

Amale Laouar, PhD
Assistant Professor of Surgery
Child Health Institute of NJ

Room 4276

Phone: (732) 235-6014
Fax: (732) 235-9534

Email: laouaram@rwjms.rutgers.edu

Laboratory
The Laouar laboratory studies the regulation of gut immunity and the roles of a novel antigen-presenting in the critical process of discrimination between pathogenic and non-pathogenic stimuli. She is also studying the interactions of the gut microbiome with the gut immune system. Her studies have implications for the pathogenesis of gastrointestinal disorders of childhood and aging, including enteric infections, food allergies, inflammatory bowel disease and cancers.

Chi Wei Lu, PhD
Assistant Professor of Obstetrics, Gynecology
and Reproductive Sciences
Child Health Institute of NJ, Room 3276

Phone: (732) 235-2870
Fax: (732) 235-8612

Email: luch@rwjms.rutgers.edu

Laboratory
The Lu laboratory studies stem cell regulation and function and is focused particularly on placental stem cells that determine the growth, differentiation and sufficiency of placental and therefore fetal development.  Her laboratory also studies genes and regulatory pathways that play a role in the development of pediatric malignancies.

 

Zhiping Pang, PhD
Assistant Professor of Neuroscience and Cell Biology
Child Health Institute of NJ
Room 3277

Phone: (732) 235-8074
Fax: (732) 235-8612

Email: pangzh@rwjms.rutgers.edu


Laboratory
Dr. Pang’s laboratory studies the neural basis of the regulation of feeding, satiety, metabolism and obesity.  His studies may provide insights into the neural causes and consequences of childhood obesity.  He has also developed novel techniques for deriving neuronal cells from primary skin cells providing novel opportunities to study the pathogenesis of neurological disorders, including pediatric developmental disorders and autism.

Lab Web site

Derek B. Sant'Angelo, PhD
Professor of Pediatrics Harold L. Paz, MD, Professorship in Developmental Biology
Chief, Division of Developmental Biology
Child Health Institute of NJ, Room 4273

Phone: (732) 235-9394
Fax: (732) 235-9534
Email: santandb@rwjms.rutgers.edu



Laboratory
The Sant'Angelo laboratory studies the regulation of NKT cells and the roles that they play in normal and pathogenic immune responses. His laboratory uses transgenic and knockout mouse models to characterize the functions of the PLZF family of transcription factors in NKT and other immune cells. His studies address fundamental issues in the pathogenesis of numerous pediatric diseases including asthma, autoimmune diseases, juvenile diabetes and cancers.

Yufang Shi, DVM, PhD
University Professor of Pharmacology
Child Health Institute of NJ
Room 4271

Phone: (732) 235-4501
Fax: (732) 235-9534

Email: shiyu@rwjms.rutgers.edu

Laboratory
The Shi laboratory studies the mechanisms and roles of cell death pathways in the regulation of the immune response.  His work probes the roles of apoptosis in the development of autoimmune and inflammatory diseases including asthma.  His laboratory also studies the roles of mesenchymal stem cells in the regulation of the immune response and is investigating the therapeutic potential of these cells for the treatment of inflammatory diseases of childhood.

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Core Facility

Mantu Bhaumik, PhD
Director, Transgeneic and Knockout Mouse Shared Resource at CINJ, CHINJ and RWJMS
Assistant Professor of Pediatrics                            Child Health Institute of NJ, Room 4270
Phone: (732) 235-9394
Fax: (732) 235-9534




Core Facility
Dr. Bhaumik directs a successful, technologically advanced core facility providing expertise in the generation and analysis of genetically-engineered mouse models of human disease.  This core facility is providing services to CINJ, CHINJ, RWJMS, Rutgers, and Princeton University scientists and has also provided expert services to some NJMS investigators.  Dr. Bhaumik also is developing new technologies and reagents for the generation of mouse models as part of his research activities.