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Céline Gélinas

Ph.D. Université de Sherbrooke, Québec, Canada, 1985
Advisor: M. Bastin
Professor
CABM, Room 137
679 Hoes Lane
Piscataway, NJ 08854-5638

http://cabm.umdnj.edu

Telephone: 848-445-9802
Facsimile: 732-235-4466
E-mail: gelinas@cabm.rutgers.edu

 

Rel/NF-kB transcription factors in gene expression, cell growth control, apoptosis and oncogenesis.

Research Fields

  • Cancer
  • Oncogenes
  • Transcription factors
  • Cell proliferation
  • Apoptosis
  • Leukemia/Lymphoma

Research Description

Cancer arises when the delicate balance between cell proliferation and cell death is perturbed. Signals that promote uncontrolled cell division, and those that block cell death, drive the development and progression of tumors. Our laboratory has a long-standing interest in the role of the Rel/NF-kB proteins in the onset and progression of hematopoietic and solid tumors. Proteins in the Rel/NF-kB-family of transcription factors play fundamental roles in immune and inflammatory responses, and are implicated in the control of cell proliferation, the inhibition of apoptosis and in oncogenesis. Experimental evidence linking deregulated Rel/NF-kB activity to human cancer has emerged in recent years, consistent with the acute oncogenicity of the Rel/NF-kB oncoprotein v-Rel in inducing fatal leukemia/lymphomas in animal models. Aberrant Rel/NF-kB activity is found in many human leukemias, lymphomas, myelomas and Hodgkin’s disease. Chromosomal amplification, rearrangement, overexpression and/or constitutive activation of the rel and nf-kB genes are also observed in breast, colon, lung and ovarian cancer. The viral and cellular Rel proteins thus provide a good model system to study how Rel/NF-kB functions in normal lymphoid cells and to understand how its aberrant activity leads to malignancy. Our research focuses on the functional domains and regulation of the Rel/NF-kB factors, and on their role in cell growth, survival and transformation. Ongoing studies focus on the transcriptional activity and regulation of the Rel/NF-kB factors, on their role in cell proliferation, apoptosis and oncogenesis, and on the cellular genes that they control. This comprehensive approach will help to clarify the mechanism by which Rel/NF-kB proteins function in the immune system and in leukemia/lymphomagenesis. In addition, since Rel/NF-kB activity has been implicated in several other disease conditions including acute inflammatory disorders, the systematic analysis of Rel/NF-kB regulation and relevant target genes may also provide important insights into novel approaches for therapeutic intervention.

 

Gélinas Laboratory

Graduate Students:

  • Gaofeng Fan

Postdoctoral Fellows:

  • Poonam Molli
  • Yanxiang (Jessie) Guo

Staff:

  • Loretta Miller, Administrative Assistant