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Publications

  • Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD, White E. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. Mar 1;25(5):460-70.

  • Fan G, Simmons MJ, Ge S, Dutta-Simmons J, Kucharczak J, Ron Y, Weissmann D, Chen CC, Mukherjee C, White E, Gélinas C. (2010) Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma. Blood. Apr 29;115(17):3559-69.

  • Drawid A, Gupta N, Nagaraj VH, Gélinas C, Sengupta AM. (2009) OHMM: a Hidden Markov Model accurately predicting the occupancy of a transcription factor with a self-overlapping binding motif. BMC Bioinformatics. 10:208.

  • Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, Dipaola RS, Karantza-Wadsworth V, White E. (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell. 137(6):1062-75.

  • Fan G, Fan Y, Gupta N, Matsuura I, Liu F, Zhou XZ, Lu KP, Gélinas C. (2009) Peptidyl-Prolyl Isomerase Pin1 Markedly Enhances the Oncogenic Activity of the Rel Proteins in the Nuclear Factor-{kappa}B Family. Cancer Res. 69(11):4589-97.

  • Simmons, M.J, Fan G, Zong, W.X., Degenhardt K, White E and Gélinas C. (2008) Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist. Oncogene 27: 1421-1428
  • Dutta J, Fan G and Gelinas C. (2008) CAPERalpha is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel/NF-kappaB oncoprotein v-Rel. J. Virol. 82: 10792-10802.
  • Fan, Y., Dutta, J., Gupta, N., Fan, G. and Gelinas, C. (2008) Regulation of programmed cell death by NF-kB and its role in tumorigenesis and therapy. Adv. Exp. Med. Biol. 615: 223-50.
  • Fan, Y. and Gelinas, C. (2007) An optimal range of transcription potency is necessary for efficient cell transformation by c-Rel to ensure optimal nuclear localization and gene-specific activation. Oncogene 26: 4038-4043.
  • Liu A, Li, J, Marin-Husstege, M, Kageyama R, Fan Y, Gelinas, C and Casaccia-Bonnefil, P. (2006) A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players. EMBO J 25: 4833-4842.
  • Fan, Y, Dutta J, Gupta N, Fan G and Gelinas C. (2006) Regulation of programmed cell death by NF-kB and its role in tumorigenesis and therapy, in Programmed cell death in cancer progression and therapy, R. Khosravi-Far, and E. White, eds. Springer: The Netherlands, In press.
  • Dutta J, Fan, Y, Gupta N, Fan G and Gelinas C. (2006) Current insights into the regulation of programmed cell death by NF-kB. Oncogene 25: 6800-6816.
  • Pegman, P.M., Smith, S.M., D'Souza, B.N., Loughran, S.T., Maier, S, Kempkes, B., Cahill, P.A., Simmons, M.J., Gelinas, C. and Walls, D. (2006) The Epstein-Barr virus nuclear antigen 2 trans-activates the cellular anti-apoptotic bfl-1 gene by a CBF-1/RBPJk dependent pathway. J. Virol. 80: 8133-8144.
  • Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson A, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, Nelson D, Jin S and White E. (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation and tumorigenesis. Cancer Cell 10: 51-64.
  • Fan Y, Dutta J, Gupta N, Gelinas C. (2006) Molecular Basis of Oncogenesis by NF-kB: From a Bird¹s Eye View to a RELevant Role in Cancer. In: Liou H-C, ed. in NF-kB/Rel Transcription Factor Family. Georgetown: Landes Bioscience/Eurekah.com, New York: Springer Science+Business Media,pp 112-130.
  • Kucharczak, J.F., Simmons, M.J., Duckett, C.S. and Gelinas, C. (2005) Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a pro-death factor. Cell Death & Differ. 12: 1225-1239.
  • Xu, C., Shen, G., Chen, C., Gelinas, C. and Kong, A.N.T. (2005) Suppression of NF-kB and NF-kB-regulated gene expression by sulforaphane and PEITC through IkBa, IKK pathway in human prostate cancer PC-3 cells. Oncogene 24: 4486-4495.
  • Gelinas, C. and White, E. (2005) BH3-only proteins in control: Specificity regulates MCL-1 and BAK-mediated apoptosis. Genes & Dev. 19: 1263-1268.
  • D’Souza, B.N., Edelstein, L.C., Pegman, P.M., Smith, S.M., Loughran, S.T., Clarke, A., Mehl, A., Rowe, M., Gelinas, C., and Walls, D. (2004) Nuclear factor kB-dependent activation of the anti-apoptotic bfl-1 gene by the Epstein-Barr virus latent membrane protein 1 and activated CD40 receptor. J. Virol. 78: 1800-1816.
  • Fan, Y., Rayet, B. and Gelinas, C. (2004) Divergent C-terminal transactivation domains of Rel/NF-kB proteins are critical determinants of their oncogenic potential. Oncogene 23: 1030-1042.
  • Kucharczak, J., Simmons, M.J., Fan, Y. and Gélinas, C. (2003) To be, or not to be: NF-kB is the answer - Role of Rel/NF-kB in the regulation of apoptosis. Oncogene. 22(56):8961-82
  • Edelstein, L.C., Lagos, L., Simmons, M., Tirumalai, H. and Gélinas, C. (2003) NF-kB-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1. Mol. Cell. Biol. 23: 2749-2761.
  • Rayet, B., Fan, Y. and Gélinas, C. (2003) Mutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kB-regulated cell death inhibitors important for v-Rel transforming activity. Mol. Cell. Biol. 23: 1520-1533.
  • Suh, J., Payvandi, F., Edelstein, L.C., Amenta, P.S., Zong, W.X., Gélinas, C., and Rabson, A.B. (2002) Mechanisms of constitutive NF-kB activation in human prostate cancer cells. Prostate, 52: 183-200
  • Jin, R., De Smaele, E., Zazzeroni, F., Nguyen, D.U., Papa, S., Jones, J., Cox, C., Gélinas, C., and Franzoso, G. (2002) Regulation of the gadd45B promoter by NF-kB. DNA Cell Biol. 21: 491-503
  • Ravi, R., Bedi, G.C., Engstrom, L.W., Zeng, Q., Mookerjee, B., Gélinas, C, Fuchs, E.J., and Bedi, A. (2001) Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kB. Nature Cell Biol. 3: 409-416.
  • Shah, N., Thomas, T.J., Lewis, J.S., Klinge, C.M., Shirahata, A., Gélinas, C., and Thomas, T. (2001) Regulation of estrogenic and nuclear factor ?B functions by polyamines and their role in polyamine analog-induced apoptosis of breast cancer cells. Oncogene 20: 1715-1729.
  • Chen C., Edelstein, L.C., and Gélinas, C. (2000) Rel/NF-kB directly activates expression of the apoptosis inhibitor Bcl-xL. Mol. Cell. Biol. 20: 2687-2695.
    Luque, I., Zong, W.-X., Chen, C. and Gélinas, C. (2000) N-terminal determinants of IkBa necessary for the cytoplasmic regulation of c-Rel. Oncogene 19: 1239-1244.
  • Zong, W-X., Edelstein, L.C., Chen, C., Bash, J., and Gélinas, C. (1999) The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-?B that blocks TNFa-induced apoptosis. Genes & Dev. 13: 382-387.
  • Bash, J., Zong, W.-X., Banga, S., Rivera, A., Ballard, D.W., Ron, Y., and Gélinas, C.(1999) Rel/NF-kB can trigger the Notch-signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J. 18: 2803-2811.
    Rayet, B. and Gélinas, C. (1999) Aberrant rel/nfkB genes and activity in human cancer. Oncogene 18: 6938-6947.
  • Chen, C., Agnès, F., and Gélinas, C. (1999) Mapping of a serine-rich domain essential for the transcriptional, anti-apoptotic and transforming activities of the v-Rel oncoprotein. Mol. Cell. Biol. 19: 307-316. Authors’ correction (2001) Mol. Cell. Biol. 20: 7115.