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Michael Hampsey, PhD Lab Site

Selected Publications

  • ROSADO-LUGO, J. and M. HAMPSEY (2014) The Ssu72 phosphatase mediates the RNA Polymerase II  initiation-elongation transition.  J. Biol. Chem. 289:33,916-33,926.

  •  SINGH, B.N. and M. HAMPSEY (2014)  Detection of short-range chromatin interactions by chromosome conformation capture (3C) in yeast.  Methods Mol. Biol. 1205:209-218.

  • YADON, A., B.N. SINGH, M. HAMPSEY and T. TSUKIYAMA  (2013)  DNA looping facilitates targeting of a chromatin remodeling enzyme. Mol. Cell 50:93-103.

  • HAMPSEY, M. (2012) A new direction for gene loops. Science 338:624-625.

  • GHAZY M.A., GORDON J.M., LEE S.D., SINGH B.N., BOHM A., HAMPSEY M., MOORE C. (2012)  The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site.  Nucleic Acids Res. 40:1214-1225.

  • GOEL, S., S. KRISHNAMURTHY and M. HAMPSEY (2012)  Mechanism of start site selection by RNA polymerase II: interplay between TFIIB and the Ssl2/XPB helicase subunit of TFIIH.  J. Biol. Chem.287: 557-567.LAINÉ, J.-P., B.N. SINGH, S. KRISHNAMURTHY and M. HAMPSEY  (2009) A physiological role for gene loops in yeast.  Genes & Dev. 23: 2604-2609.

  • KRISHNAMURTHY, S. and M. HAMPSEY (2009) Eukaryotic transcription initiation.Curr. Biol. 19:R153-R156
  • GHAZY, M., X. HE, B.N. SINGH, M. HAMPSEY and C. MOORE  (2009)  The essential N-terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ssu72 function but is dispensable for pre-mRNA 3’-end processing.  Mol. Cell. Biol. 29: 2296-2307.
  • KRISHNAMURTHY, S., M. A. GHAZY, C. MOORE and M. HAMPSEY (2009) Functional interaction of the Ess1 prolyl isomerase with components of the RNA polymerase II initiation and termination machineries. Mol. Cell. Biol. 29:2925-2934.
  • SINGH, B.N., A. ANSARI and M. HAMPSEY (2009) Detection of transient short-range chromatin interactions by 3C in yeast.  Methods 48:361-367.
  • ESTRELLA, L. A., S. KRISHNAMURTHY, C. R. TIMME and M. HAMPSEY (2008) The Rsp5 E3 ligase mediates turnover of low-affinity phosphate transporters inSaccharomyces cerevisiae. J. Biol. Chem. 283:5327-5334.
  •  SINGH, B. N. and M. HAMPSEY (2007) A transcription-independent role for TFIIB in gene looping. Mol. Cell 27:806-816.
  • REYES-REYES, M. and M. HAMPSEY (2007) Role for the Ssu72 C-terminal domain phosphatase in RNA polymerase II transcription elongation. Mol. Cell. Biol. 27:926-936.
  • HAMPSEY, M. (2006) The RNA polymerase II initiation complex: looking for a place to start. Nat. Struct. Mol. Biol. 13 :564-566.
  • ANSARI, A. and M. HAMPSEY (2005) A role for the CPF 3'-end processing machinery in RNAP II-dependent gene looping. Genes & Dev. 19 :2969-2978. 
  • KRISHNAMURTHY, S., X. HE, M. REYES-REYES, C. MOORE AND M. HAMPSEY (2004) Ssu72 is a RNA polymerase II CTD phosphatase. Mol. Cell 14 :387-394.
  • CHEN, B.-S. and M. HAMPSEY (2004) Functional interaction between TFIIB and the Rpb2 subunit of RNA polymerase II: implications for the mechanism of transcription start site selection. Mol. Cell Biol. 24 :3983-3991.
  • HAMPSEY, M. and D. REINBERG (2003)  Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Cell 113 :429-432. 
  • HE, X., A.U. KHAN, H. CHENG, D.L. PAPPAS, M. HAMPSEY and C.L. MOORE   (2003)  Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1. Genes & Dev. 17 :1030-1042.
  • WOYCHIK, N.A. and M. HAMPSEY  (2002)  The RNA polymerase II machinery: structure illuminates function. Cell 108 :453-463.