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Publications

  • Barbieri CM, Mack TR, Robinson VL, Miller MT, Stock AM. (2010) Regulation of response regulator autophosphorylation through interdomain contacts. J Biol Chem. Oct 15;285(42):32325-35. Epub 2010 Aug 11 .

  • Gao R, Stock AM. (2010) Molecular strategies for phosphorylation-mediated regulation of response regulator activity. Curr Opin Microbiol. 13(2):160-7.

  • Gao R, Stock AM. (2009) Catalytically incompetent by design. Structure. 17(8):1038-40.

  • Gao R, Stock AM. (2009) Biological insights from structures of two-component proteins. Annu Rev Microbiol. 63:133-54.

  • Mack TR, Gao R, Stock AM. (2009) Probing the roles of the two different dimers mediated by the receiver domain of the response regulator PhoB. J Mol Biol. 389(2):349-64.

  • Guhaniyogi J, Sohar I, Das K, Stock AM, Lobel P. (2009) Crystal structure and autoactivation pathway of the precursor form of human tripeptidyl-peptidase 1, the enzyme deficient in late infantile ceroid lipofuscinosis. J Biol Chem. Feb 6;284(6):3985-97
  • Gao R, Tao Y, Stock AM. (2008) System-level mapping of Escherichia coli response regulator dimerization with FRET hybrids. Mol Microbiol. 69(6):1358-72.
  • Sidote DJ, Barbieri CM, Wu T, Stock AM. (2008) Structure of the Staphylococcus aureus AgrA LytTR domain bound to DNA reveals a beta fold with an unusual mode of binding. Structure. 16(5):727-35.
  • Barbieri CM, Stock AM. (2008) Universally applicable methods for monitoring response regulator aspartate phosphorylation both in vitro and in vivo using Phos-tag-based reagents. Anal Biochem. 376(1):73-82.
  • Guhaniyogi J, Wu T, Patel SS, Stock AM. (2008) Interaction of CheY with the C-terminal peptide of CheZ. J Bacteriol. 190(4):1419-28.
  • Dixit SS, Sleat DE, Stock AM, Lobel P. (2007) Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption? Biochem J. 408(1):1-5. Stock AM. (2007) Diguanylate cyclase activation: it takes two. Structure. 15(8):887-8.
  • Xu S, Benoff B, Liou HL, Lobel P, Stock AM. (2007) Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease. J Biol Chem. 282(32):23525-31.
  • Bachhawat P, Stock AM. (2007) Crystal structures of the receiver domain of the response regulator PhoP from Escherichia coli in the absence and presence of the phosphoryl analog beryllofluoride. J Bacteriol. 189(16):5987-95.
  • Friedland N, Mack TR, Yu M, Hung LW, Terwilliger TC, Waldo GS, Stock AM. (2007) Domain orientation in the inactive response regulator Mycobacterium tuberculosis MtrA provides a barrier to activation. Biochemistry. 46(23):6733-43.
  • Gao R, Mack TR, Stock AM. (2007) Bacterial response regulators: versatile regulatory strategies from common domains. Trends Biochem Sci. 32(5):225-34.
  • Perez E, Stock AM. (2007) Characterization of the Thermotoga maritima chemotaxis methylation system that lacks pentapeptide-dependent methyltransferase CheR:MCP tethering. Mol Microbiol. 63(2):363-78.
  • Stock AM, Guhaniyogi J. (2006) A new perspective on response regulator activation. J Bacteriol. 188(21):7328-30.
    Stock AM. (2006) Transmembrane signaling by asymmetry. Nat Struct Mol Biol. 13(10):862-3.
  • Liou HL, Dixit SS, Xu S, Tint GS, Stock AM, Lobel P. (2006) NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols. J Biol Chem. 281(48):36710-23.
  • Perez E. Zheng H. Stock AM. (2006) Identification of methylation sites in Thermotoga maritima chemotaxis receptors. J Bacteriol. 188(11):4093-100.
  • Guhaniyogi J. Robinson VL. Stock AM. (2006) Crystal structures of beryllium fluoride-free and beryllium fluoride-bound CheY in complex with the conserved C-terminal peptide of CheZ reveal dual binding modes specific to CheY conformation. J Mol Biol. 359(3):624-45.
  • Toro-Roman A. Wu T. Stock AM. (2005) A common dimerization interface in bacterial response regulators KdpE and TorR. Protein Sci. 14(12):3077-88.
    Bachhawat. P. Swapna. G.V.T.. and Stock. A.M. (2005). Mechanism of activation for transcription factor PhoB suggested by different modes of dimerization in the inactive and active states. Structure. 13(9):1353-63.
  • Toro-Roman A.. Mack. T.R. and Stock. A.M. (2005). Structural analysis and solution studies of the activated regulatory domain of the response regulator ArcA: a symmetric dimer mediated by the alpha4-beta5-alpha5 face. J. Mol. Biol. 349: 11-26.
  • Perez. E.. West. A.H.. Stock. A.M. and Djordjevic. S. (2004). Discrimination between different methylation states of chemotaxis receptor Tar by receptor methyltransferase CheR. Biochemistry 45: 953-961.
  • Robinson. V.L.. Wu. T. and Stock. A.M. (2003). Structural analysis of the domain interface in DrrB. a response regulator of the OmpR/PhoB subfamily. J. Bacteriol. 185:4186-4194.
  • Friedland. N.. Liou. H.-L.. Lobel. P. and Stock. A.M. (2003). Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease. Proc. Natl. Acad. Sci. USA 100:2512-2517.
  • Bourret. R.B. and Stock. A.M. (2002). Molecular information processing: lessons from bacterial chemotaxis. J. Biol. Chem. 277:9625-9628.