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David J. Foran, Ph.D.                            

Present Titles
Professor
Department of Pathology and Laboratory Medicine
Chief, Division of Medical Informatics
Director, Center for Biomedical Imaging

Office Address:
Department of Pathology and Laboratory Medicine
Robert Wood Johnson Medical School
675 Hoes Lane, R201
Piscataway, NJ 08854

Lab Website: http://pleiad.umdnj.edu/CBII/                            

Description of Clinical Expertise:

Clinical focus on the design, development, and implementation of new approaches in computer-assisted diagnostics, medical imaging and statistical pattern recognition for resolving challenging clinical problems in pathology, radiology, and oncology

Description of Research Expertise:

A major concentration for  laboratory has been the development of a family of data-mining, imaging and computational tools for characterizing the morphologic profiles exhibited by a wide range of malignancies and elucidating the role that protein and molecular expression plays in disease onset and progression. This research has led to the development of:

  • An image-guided screening system for discriminating among commonly confused malignant lymphomas and leukemia
  • A robotic system for performing automated imaging, evaluation, and archiving of tissue microarrays
  • An automated means for 3-D detection, characterization, and tracking of hepatic neoplasms from spiral CT
  • A new approach for characterizing neuroanatomy from MR images using mathematical morphometry and
    cluster analysis
  • A high-throughput, grid-enabled decision support system for performing quick, reliable comparative analysis
    and classification of expression patterns in imaged cancer tissue microarrays and pathology specimens

Undergraduate Education:

1983  B.A.    Rutgers University. Curriculum:  Zoology and Physics    

Graduate Education:

1992 Ph.D.  Rutgers University & University of Medicine and Dentistry of New Jersey

Postdoctoral Training:

1992-1993  Research Associate. Dept. of  Pathology & Laboratory Medicine.
UMDNJ - Robert Wood Johnson Medical School

Selected Publications:

  • David J. Foran,  Dorin Comaniciu, Peter Meer, and Lauri A. Goodell. Computer Assisted Discrimination Among Malignant Lymphomas and Leukemia Using Immunophentyping, Intelligent Image Repositories and Telemicroscopy. IEEE Trans. On Information Technology in Biomedicine, Vol. 4:4, pages 265-273. 2000.
  • Wenjin Chen, Michael Reiss, and David J. Foran. Unsupervised Tissue MicroarrayAnalysis for Cancer Research and Diagnostics. IEEE Transactions on Information Technology in Biomedicine. Vol. 8: No. 2, pages 89-96. 2004.
  • Wenjin Chen, Peter Meer, Bogdan Georgescu, Wei He, Lauri A. Goodell, David J. Foran. Image Mining for Investigative Pathology Using Optimized Feature Extraction and Data Fusion. Computer Methods and Programs in Biomedicine. July; 79(1): 59-72. 2005.
  • Lin Yang, Peter Meer, David J. Foran. Unsupervised Analysis of Imaged Pathology Specimens Based on Robust Estimation and Color Active Contour Models. IEEE Transactions on Information Technology in Biomedicine. IEEE Transactions on Information Technology in Biomedicine. Vol. 9: 3; 475-486. Sept; 9(3):2005.
  • Wenjin Chen, Cristina Schmidt, Manish Parashar, Michael Reiss, David J. Foran. Decentralized Data Sharing of Tissue Microarrays for Investigative Research in Oncology. Cancer Informatics. Vol. 2: 373–388, 2006.
  • Robert S. DiPaola, Dmitri Dvorzhinski, Anu Thalisila, Venkata Garikapaty, Michael May, K. Bray, Brian Beaudoin, C. Karp, Wenjin Chen, David J. Foran, Eileen White. Therapeutic Starvation and Autophagy in Prostate Cancer: A New Paradigm for Targeting Metabolism in Cancer Therapy. Prostate. Sept. 2, 2008.
  • Bonnie H. Hall, Monica Ianosi-Irimie, Parisa Javidian, Wenjin Chen, Shridar Ganesan, David J. Foran. Computer Assisted Assessment of the Human Epidermal Growth Factor Receptor 2 Immunohistochemical Assay in Histologic Sections Using a Membrane Isolation Algorithm and Quantitative Analysis of Positive Controls. BMC Medical Imaging. Vol. 8:11, 2008.
  • Gabriela Niculescu, John L. Nosher, David J. Foran. 3-D Morphometry and Non-Rigid Registration for Quantitative Analysis and Clinical Assessment in Radiology. International Journal of Computer Assisted Radiology and Surgery. International Journal of Computer Assisted Radiology and Surgery. 4(4):337-47, 2009.
  • Lin Yang, Wenjin Chen, Peter Meer, Michael D. Feldman, Lauri A. Goodell, Adam Bagg, Wei He, David J. Foran. PathMiner: A Web Based Tool for Computer Assisted Diagnostics in Pathology. IEEE Transactions on Information Technology in Biomedicine.13(3):291-299, 2009.
  • Lin Yang, Wenjin Chen, Gratian Salaru, Lauri A. Goodell, Viktors Berstis, and David J. Foran. Virtual Microscopy & Grid-enabled Decision Support for Large-Scale Analysis of Imaged Pathology Specimens. IEEE Transactions on Information
  • Xin Qi, Fuyong Xing, David J. Foran, Lin Yang. GPU-Enabled Parallel Touching Cell Segmentation Using Mean-Shift Based Seed Detection and Repulsive Level Set. The 2nd International Workshop on High-Performance Medical Image Computing for Image-Assisted Clinical Intervention and Decision-Making.  Bejing, China. Invited Paper. Pages 12-21, 2010.
  • David J. Foran, Wenjin Chen, Lin Yang, Jun Hu, Lauri A. Goodell, Michael Reiss, Tahsin Kurc, Renato Ferreira, Metin Gurcan, Tony Pan, Joel H. Saltz. Image-Miner: Comparative Analysis of Tissue Microarrays using Content-based Image Retrieval, High-Performance Computing and Grid Technology. Journal of the American Medical Informatics Association. In press.