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Research

Nancy Reichman, PhD:

Ongoing projects:

1. Low birthweight among immigrants to the United States: cohort,duration,age-at-arrival, and region of origineffects.

2. Neonatal and longer-term outcomes of late preterm infants

Future projects:

  • Effects of infant health shocks on family food insecurity
  •  Effects of postpartum depression on social interactions
  • Testing the "weathering hypothesis" using longitudinally linked birth certificate data from NJ

Barry Weinberger, MD:

Ongoing projects:

  • Effects of mesenchymal stem cells on inflammation in neonates
  • Toxicity of phthalates and bisphenol A in neonates
  • Effects of PUFA and nitrated fatty acids on neutrophil function
  • Protective effects of fatty acids in phthalate-induced inflammation
  • Endocrine disruption and inflammatory effects of environmental toxicants on fetuses
  • Psychosocial challenges of mothers of premature infants

Future projects:

  • Mechanisms of inflammatory lung disease in neonates
  • Association of feeding intolerance with markers of oxidative and nitrosative stress in stool of VLBW infants

Rajeev Mehta, MD:

Ongoing projects:

  • Energy metabolism mediators, type of feeding and growth in preterm born infants
  • Cerebral and renal tissue oxygenation during pre-discharge car seat testing in preterm born infants

Future projects:

  • Tissue oxygenation studies - Near Infra-Red Spectroscopy

Michael Giuliano, MD:

Ongoing projects:

Characterization and quantification of diagnostic errors in the NICU setting

Future projects:

  • Placental pathology in IUGR and SGA
  • Efficacy of Vitamin D supplementation in the NICU
  • Gentamin and vancomycin pharmacokinetics in neonates

Lauren Aleksunes, PhD:

Ongoing projects:

Placental drug and xenobiotic transfer: Basic science and translational research on the placental BCRP efflux transporter and understanding how genetic polymorphisms may affect transplacental drug and xenobiotic transfer

Surasak Puvabanditsin, MD:

Ongoing projects:

Inhaled Nitric Oxide For The Prevention Of Bronchopulmonary Dysplasia (BPD) In Preterm Infants Requiring Mechanical Ventilation Or Positive Pressure Support On Days 5-14 After Birth (IK-3001-BPD-301

Future projects:

Randomizes, Double Blind, Multi-Center Study to Compare the efficacy and Safety of Micafungin Versus Amphotericin B Deoxycholate for the Treatment of Neonatal Cadidiasis

Judy Saslow, MD:

Ongoing projects:

1. Beevers Manufacturing & Supply, Inc.

Does the use of the Cannulaide® nasal seal provide better support for very low birth weight infants on nasal continuous positive airway pressure (NCPAP)?

June 2006-present

2. Yale University School of Medicine

Genome Wide Association for Bronchopulmonary Dysplasia

2008-present

3. Columbia Life Systems, Inc.

Comparison of SmartBlender and Standard Approach to Optimize Oxygenation of Preterm Infants

2009-present

4. American Lung Association

Role of transcription factors (NF-kB and AP-1) in the pathogenesis of neonatal chronic ling disease.

  1. Role of transcription factors (NF-kB and AP-1) in the pathogenesis of chorioamnionitis and neonatal mortality and morbidity. (PI, J Saslow).
  2. Expression of transcriptional factors, pro and anti-inflammatory cytokines in the lungs of premature neonates.
  3. Changes in Lung Volume and Work of Breathing: A comparison of Nasal Cannula (NC) with Nasal Continuous Positive Airway Pressure (NCPAP), and Vapotherm (VAPO) in Very Low Birth Weight Infants
  4. Inflammatory mediators in tracheal aspirates and the development of bronchopulmonary dysplasia (BPD) in preterm infants

Gary Stahl, MD:

Ongoing projects:

1. National Institutes of Health and PortaScience, Inc:

SBIR Phase II Application: Development of a Point-Of-Care Test for Determining Bilirubin in Whole Blood

2. Effect of Indomethacin and Ibuprofen on Free Bilirubin Levels in Premature Infants.

Alla Kushnir, MD:

Ongoing projects:

  1. Is the use of C-reactive protein beneficial in diagnosing neonatal sepsis and limiting antibiotic use?
  2. Long Term Neuroprotective Effects of Hypothermia and Adipose Tissue Derived Stem Cells in Neonatal Rats post Hypoxic Ischemic Encephalopathy.
  3. Analysis of central line clots (QI project)
  4. Oxygen saturation and ROP in Neonates of Different Gestational Ages
  5. Does permissive hypercapnia have long term benefits?

Future projects:

  • Utility of Mock Codes in Pediatric Residentcy Training Programs
  • The use of morphine with/without phenobarb for the treatment of Neonatal Abstinence Syndrome

Eric Brandsma, MD:

Ongoing projects:

  1. The heat is on! Improving admission temperatures in the Neonatal ICU.

Gretchen Lawhon, PhD, RN:

Future projects:

  • Stability of Infant Responses to Painful Procedures study I had worked on in the past. (80 preterm infants with 18,998 painful procedures) Obtained and reclaimed huge data base from previous study Obtained huge database from previous NINR funded study
  • Neurobehavioral maturation with increasing post conceptual age (PCA) as measured by serial Assessment of Preterm Infant’s Behavior (APIB) system scoring.
  • Correlations in neurobehavioral functioning as measured by system scoring of the Assessment of Preterm Infant’s Behavior (APIB) with infants 35-46 weeks post conceptual age (PCA).
  • There has been some discussion, background reading and thought put into a study that would look at preterm infants’ early vocalization patterns in the NICU with a three armed design of: 1- parents interacting with their infants in the routine status, 2 – parents encouraged to read to their preterm infant on a daily basis; and 3 – parents encouraged to talk with their infants on an ongoing basis.