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Huizhou Fan, M.D., Ph.D.


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Selected Publications:

Bao, X., B.W.L. Beatty, H. Fan, 2012. Exploration of chlamydial type III secretion system reconstitution in Escherichia coil. PLOS ONE.

Bao, X., B. E. Nickels, H. Fan, 2012.  Chlamydia trachomatis protein GrgA activates transcription by contacting the non-conserved region of s66.  Proceedings of National Academy of Science USA. In press.

Fan, H. 2012.  Blindness-causing trachomatous trichiasis biomarkers sighted.  Investigative Ophthalmology andVision Science.  53: 2560.

Klionsky, D.J. et al. 2012.  Guidelines for the use and interpretation of assays for monitoring autophagy.  Autophagy 8:445-544.

Li, X., L. Perez, H. Fan. 2011. The cytotail of TACE/ADAM17 plays an inhibitory role in protein ectodomain shedding. World J. Biol. Chem. 2:246-251."

Yasir, M*., N. Pachikara*, X. Bao*, Z. Pan, and H. Fan. 2011. Regulation of chlamydial infection by host autophagy and vacuolar ATPase-bearing organelles.  Infection and Immunity.  79:4019-28  

Bao, X.*, N. D. Pachikara*, C. Oey, A. Balakrishnan, L. F. Westblade, M. Tan, T. Chase, B. E. Nickels, and H. Fan. 2011. Noncoding Nucleotides and Amino Acids near the Active Site Regulate Peptide Deformylase Expression and Inhibitor Susceptibility in Chlamydia trachomatis. Microbiology 157: 2569-2581.

Oey, C. B.*, X. Bao*, C. Lewis, J. E. Kerrigan, and H. Fan. 2011. High tolerance to mutations in a Chlamydia trachomatis peptide deformylase loop. World J. Biol. Chem. 2:90-97. (Figure was featured on journal cover)

Mo, X., N. X. Nguyen, F. T. Mu, W. Yang, S. Z. Luo, H. Fan, R. K. Andrews, M. C. Berndt, and R. Li. 2010. Transmembrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibalpha. J. Biol. Chem. 285:32096-32104.

Pachikara, N., H. Zhang, Z. Pan, S. Jin, H. Fan. 2009. Productive Chlamydia trachomatis lymphogranuloma venereum 434 infection in cells with augmented or inactivated autophagic activities. FEMS Microbiol. Lett. 292:240-249.

Balakrishnan, A., L. Wang, X. Li, P. Ohman-Strickland, P. Malatesta, H. Fan. 2009. Inhibition of chlamydial infection in the genital tract of female mice by topical application of a peptide deformylase inhibitor. Microbiol. Res. 164:338-346.

Li, X., L. Perez, Z. Pan, H. Fan. 2007. The transmembrane domain of TACE regulates protein ectodomain shedding. Cell Res. 17:985-998.

Perez, L., X. Li, J. Kerrigan, H. Fan. 2007. Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity. Biochem. Cell Biol. 85:141-149.

Balakrishnan, A., B. Patel, S. A. Sieber, D. Chen, N. Pachikara, G. Zhong, B. F. Cravatt, and H. Fan. 2006. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J. Biol. Chem. 281:16691-16699 .

Li, X., H. Fan. 2004. Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-a converting enzyme (TACE). J. Biol. Chem. 279:27365-75.

Fan, H., C.W. Turck, R. Derynck. 2003. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-a converting enzyme (TACE) and of an alternatively translated polypeptide. J. Biol. Chem. 278:18017-18027.