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Huizhou Fan, M.D., Ph.D.

 


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Selected Publications:

Bao, X., B.W.L. Beatty, H. Fan, 2012. Exploration of chlamydial type III secretion system reconstitution in Escherichia coil. PLOS ONE.

Bao, X., B. E. Nickels, H. Fan, 2012.  Chlamydia trachomatis protein GrgA activates transcription by contacting the non-conserved region of s66.  Proceedings of National Academy of Science USA. In press.

Fan, H. 2012.  Blindness-causing trachomatous trichiasis biomarkers sighted.  Investigative Ophthalmology andVision Science.  53: 2560. http://www.ncbi.nlm.nih.gov/pubmed/22586179

Klionsky, D.J. et al. 2012.  Guidelines for the use and interpretation of assays for monitoring autophagy.  Autophagy 8:445-544. http://www.landesbioscience.com/journals/autophagy/2012AUTO0036.pdf

Li, X., L. Perez, H. Fan. 2011. The cytotail of TACE/ADAM17 plays an inhibitory role in protein ectodomain shedding. World J. Biol. Chem. 2:246-251. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224872/pdf/WJBC-2-246.pdf"

Yasir, M*., N. Pachikara*, X. Bao*, Z. Pan, and H. Fan. 2011. Regulation of chlamydial infection by host autophagy and vacuolar ATPase-bearing organelles.  Infection and Immunity.  79:4019-28 http://iai.asm.org/cgi/reprint/79/10/4019  

Bao, X.*, N. D. Pachikara*, C. Oey, A. Balakrishnan, L. F. Westblade, M. Tan, T. Chase, B. E. Nickels, and H. Fan. 2011. Noncoding Nucleotides and Amino Acids near the Active Site Regulate Peptide Deformylase Expression and Inhibitor Susceptibility in Chlamydia trachomatis. Microbiology 157: 2569-2581. http://mic.sgmjournals.org/content/157/9/2569.full.pdf

Oey, C. B.*, X. Bao*, C. Lewis, J. E. Kerrigan, and H. Fan. 2011. High tolerance to mutations in a Chlamydia trachomatis peptide deformylase loop. World J. Biol. Chem. 2:90-97. (Figure was featured on journal cover) http://www.ncbi.nlm.nih.gov/pubmed/21666811

Mo, X., N. X. Nguyen, F. T. Mu, W. Yang, S. Z. Luo, H. Fan, R. K. Andrews, M. C. Berndt, and R. Li. 2010. Transmembrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibalpha. J. Biol. Chem. 285:32096-32104.
http://www.ncbi.nlm.nih.gov/pubmed/20716526

Pachikara, N., H. Zhang, Z. Pan, S. Jin, H. Fan. 2009. Productive Chlamydia trachomatis lymphogranuloma venereum 434 infection in cells with augmented or inactivated autophagic activities. FEMS Microbiol. Lett. 292:240-249.
http://www3.interscience.wiley.com/cgi-bin/fulltext/121670538/PDFSTART

Balakrishnan, A., L. Wang, X. Li, P. Ohman-Strickland, P. Malatesta, H. Fan. 2009. Inhibition of chlamydial infection in the genital tract of female mice by topical application of a peptide deformylase inhibitor. Microbiol. Res. 164:338-346.
http://www.sciencedirect.com/science/journal/09445013

Li, X., L. Perez, Z. Pan, H. Fan. 2007. The transmembrane domain of TACE regulates protein ectodomain shedding. Cell Res. 17:985-998.
http://www.nature.com/cr/journal/v17/n12/pdf/cr200798a.pdf

Perez, L., X. Li, J. Kerrigan, H. Fan. 2007. Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity. Biochem. Cell Biol. 85:141-149.
http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=0829-8211&volume=85&issue=1&startPage=141

Balakrishnan, A., B. Patel, S. A. Sieber, D. Chen, N. Pachikara, G. Zhong, B. F. Cravatt, and H. Fan. 2006. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J. Biol. Chem. 281:16691-16699 . http://www.jbc.org/cgi/reprint/M513648200v1

Li, X., H. Fan. 2004. Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-a converting enzyme (TACE). J. Biol. Chem. 279:27365-75.
http://www.jbc.org/cgi/content/full/279/26/27365

Fan, H., C.W. Turck, R. Derynck. 2003. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-a converting enzyme (TACE) and of an alternatively translated polypeptide. J. Biol. Chem. 278:18017-18027.
http://www.jbc.org/cgi/content/full/278/20/18617