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Jerome Langer, Ph.D.

Associate Professor
Phone Office: (732) 235-5224
Phone Lab: (732) 235-5454
E-mail: langer@rwjms.rutgers.edu

Office: RWJMS 729
Lab: RWJMS 715 and 713

 

Research Interest:

Interferon, interferon receptors, lupus, protein design.

 

Research Description:

My lab is continuing our work to understand how the Type I interferon receptor on cells differentially recognizes and responds to the range of Type I interferons, including 13 or more alpha interferons, beta interferon, omega interferon, and others.

We have recently applied the knowledge derived from our analysis of interferon:receptor interactions to design novel interferon-derived Type I interferon antagonists (Pan et al. 2008. Biochemistry 47, 12018-27). Since the inappropriate expression of Type I interferons appears to be part of the pathogenesis of several autoimmune diseases, such as systemic lupus erythematosus (lupus), and Type 1 (juvenile) diabetes, as well as in several animal models of these diseases, there is great interest in developing novel interferon antagonists as research tools and possibly as human therapeutics. We are trying to develop improved human and mouse interferon antagonists and to initiate in vivo studies with these antagonists to better understand the role of interferon in these diseases, and to possibly develop therapeutic molecules for clinical use.

Overview

Publications