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Kiran Madura, Ph.D.

 

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Selected Publications:

Chen L, Romero L, Chuang SM, Tournier V, Joshi KK, Lee JA, Kovvali G, Madura K. (2011) Sts1 plays a key role in targeting proteasomes to the nucleus. J Biol Chem. Jan 28;286(4):3104-18.

Kipen HM, Gandhi S, Rich DQ, Ohman-Strickland P, Laumbach R, Fan ZH, Chen L, Laskin DL, Zhang J, Madura K. (2010) Acute Decreases in Proteasome Pathway Activity Following Inhalation of Fresh Diesel Exhaust or Secondary Organic Aerosol. Environ Health Perspect. Dec 15. [Epub ahead of print]

Chandra A, Chen L, Madura K. (2010) Synthetic lethality of rpn11-1 rpn10Δ is linked to altered proteasome assembly and activity. Curr Genet. Dec;56(6):543-57.

Chandra A, Chen L, Liang H, Madura K. (2010) Proteasome assembly influences interaction with ubiquitinated proteins and shuttle factors. J Biol Chem. 285(11):8330-9.

Madura K. (2009) Cell biology: The proteasome assembly line. Nature. 459(7248):787-8.

Hedhli N, Lizano P, Hong C, Fritzky LF, Dhar SK, Liu H, Tian Y, Gao S, Madura K, Vatner SF, Depre C. (2008) Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload. Am J Physiol Heart Circ Physiol. 295(4):H1385-93.

Geetha T, Seibenhener ML, Chen L, Madura K, Wooten MW. (2008) p62 serves as a shuttling factor for TrkA interaction with the proteasome. Biochem Biophys Res Commun. Sep 12;374(1):33-7.

Chen L, Madura K. (2008) Centrin/Cdc31 is a novel regulator of protein degradation. Mol Cell Biol. 28(5):1829-40.

Hedhli N, Wang L, Wang Q, Rashed E, Tian Y, Sui X, Madura K, Depre C. (2008) Proteasome activation during cardiac hypertrophy by the chaperone H11 Kinase/Hsp22. Cardiovasc Res. 77(3):497-505.

Romero-Perez L, Chen L, Lambertson D, Madura K. (2007) Sts1 can overcome the loss of Rad23 and Rpn10 and represents a novel regulator of the ubiquitin/proteasome pathway. J Biol Chem. 282(49):35574-82.

Depre C, Wang Q, Yan L, Hedhli N, Peter P, Chen L, Hong C, Hittinger L, Ghaleh B, Sadoshima J, Vatner DE, Vatner SF, Madura K. (2006) Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation. 114(17):1821-8.

Chen L. Thiruchelvam MJ. Madura K. Richfield EK. (2006) Proteasome dysfunction in aged human alpha-synuclein transgenic mice. Neurobiol Dis. 23(1):120-6.

Chen L. Madura K. (2006) Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B. FEBS Lett. 580(14):3401-8.

Chuang SM. Madura K. (2005) Saccharomyces cerevisiae Ub-conjugating enzyme Ubc4 binds the proteasome in the presence of translationally damaged proteins. Genetics. 171(4):1477-84.

Chen. L. and Madura. K. (2005). Increased proteasome activity. ubiquitin-conjugating enzymes and eEF1A translation factor detected in breast cancer tissue. Cancer Res. 65:13-20.

Chuang. S-M.. Chen. L.. Lambertson. D.. Anand. M.. Kinzy. T. G. and Madura. K. (2005). Proteasome-mediated degradation of co-translationally damaged proteins involves the translation elongation factor eEF1A. Mol. Cell. Biol. Vol. 25: 403-413.

Doss-Pepe. E.. Chen. L. and Madura. K. (2005). Alpha-Synuclein and Parkin contribute to the assembly of ubiquitin lysine63-linked multiubiquitin chains. J Biol Chem.. 280:16619-24.

Ortolan. T. G.. Chen. L.. Tongaonkar. P. and Madura. K. (2004). Rad23 stabilizes Rad4 from degradation by the Ub/proteasome pathway. Nuc. Acids Res. 34: 1-11.

Madura. K. (2004). Rad23 and Rpn10: Perennial wallflowers join the melee. Trends in Biochem. Sci. 29: 637-40.

Johnston. JA and Madura. K. (2004). Rings. Chains and Ladders; Ubiquitin goes to work in the neuron. Progress in Neurobiology 73: 227-257.

Doss-Pepe. E. W.. Stenroos. E. S.. Johnson. W. G. and Madura. K. (2003). Ataxin-3 interactions with Rad23 and Valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis. Mol. Cell. Biol. 23: 6469-6483.

Lambertson. D.. Chen. L. and Madura. K. (2003). Investigating the importance of proteasome-interaction for Rad23 function. Current Genetics 42: 199-208.
Chen. L. and Madura. K. (2002). Rad23 promotes the targeting of proteolytic substrates to the proteasome. Mol. Cell. Biol.. 22: 4902-4913.

Madura. K. (2002). The Ubiquitin-Associated (UBA) domain: On the path from prudence to prurience. Cell Cycle 4: 235-244.

Sweder. K. and Madura. K. (2002). Regulation of repair by the 26S proteasome. Journal of Biomedicine and Biotechnology. 2: 94-105.

Chen. L.. Shinde. U.. Ortolan. T. G. and Madura. K. (2001). UBA domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly. EMBO R.. 2: 933-938.

Ortolan. T.. Chen. L.. Lambertson. D. and Madura. K. (2000). The Rad23 protein is a negative regulator of multiubiquitin chain assembly. Nature Cell Biology. 2: 601-608.