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Daniel S. Pilch, Ph.D.



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Selected Publications:

Pilch, D. S., Barbieri, C. M., Rzuczek, S. G., LaVoie, E. J. & Rice, J. E. (2008)    “Targeting Human Telomeric G-Quadruplex DNA with Oxazole-Containing Macrocyclic Compounds” Biochimie 90, 1233-1249

Satyanarayana, M., Rzuczek, S. G., LaVoie, E. J., Pilch, D. S., Liu, A., Liu, L. F. & Rice, J. E. (2008) “Ring-Closing Metathesis for the Synthesis of a Highly G-Quadruplex Selective Macrocyclic Hexaoxazole Having Enhanced Cytotoxic Potency” Bioorg. Med. Chem. Lett. 18, 3802-3804.

Rzuczek, S. G., Pilch, D. S., LaVoie, E. J. & Rice, J. E. (2008) “Lysinyl Macrocyclic Hexaoxazoles: Synthesis and Selective G-Quadruplex Stabilizing Properties” Bioorg. Med. Chem. Lett. 18, 913-917.

Kondo, J., Hainrichson, M., Nudelman, I., Shallom-Shezifi, D., Barbieri, C. M., Pilch, D. S., Westhof, E. & Baasov, T. (2007) “Differential Selectivity of Natural and Synthetic Aminoglycosides Towards the Eukaryotic and Prokaryotic Decoding A Sites” ChemBioChem 8, 1700-1709.

Barbieri, C. M., Srinivasan, A. R., Rzuczek, S. G., Rice, J. E., LaVoie, E. J. & Pilch, D. S. (2007) “Defining the Mode, Energetics, and Specificity with Which a Macrocyclic Hexaoxazole Binds to Human Telomeric G-Quadruplex DNA” Nucleic Acids Res. 35, 3272-3286.

Kaul, M., Barbieri, C. M., Srinivasan, A. R. & Pilch, D. S. (2007) “Molecular Determinants of Antibiotic Recognition and Resistance by Aminoglycoside Phosphotransferase (3)-IIIa: A Calorimetric and Mutational Analysis” J. Mol. Biol. 369, 142-156.

Barbieri, C. M., Kaul, M., Bozza-Hingos, M., Zhao, F., Tor, Y., Hermann, T. & Pilch, D. S. (2007) “Defining the Molecular Forces That Determine the Impact of Neomycin on Bacterial Protein Synthesis: Importance of the 2-Amino Functionality” Antimicrob. Agents Chemother. 51, 1760-1769.