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Monica Roth, Ph.D.


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Selected Publications:

Zhang X, Roth MJ. (2010) Antibody-directed lentiviral gene transduction in early immature hematopoietic progenitor cells. J Gene Med. Dec;12(12):945-55.

Tang Y, Schneider WM, Shen Y, Raman S, Inouye M, Baker D, Roth MJ, Montelione GT. (2010) Fully automated high-quality NMR structure determination of small (2)H-enriched proteins. J Struct Funct Genomics. Dec;11(4):223-32.

Schneider WM, Tang Y, Vaiphei ST, Mao L, Maglaqui M, Inouye M, Roth MJ, Montelione GT. (2010) Efficient condensed-phase production of perdeuterated soluble and membrane proteins. J Struct Funct Genomics. Jun;11(2):143-54.

Schneider WM, Inouye M, Montelione GT, Roth MJ. (2009) Independently inducible system of gene expression for condensed single protein production (cSPP) suitable for high efficiency isotope enrichment. J Struct Funct Genomics. 10(3):219-25.

Mazari PM, Linder-Basso D, Sarangi A, Chang Y, Roth MJ. (2009) Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor. Proc Natl Acad Sci U S A. 106(14):5848-53.

Vera J, Valenzuela B, Roth MJ, León O. (2008) Characterization of the long-terminal repeat single-strand tail-binding site of Moloney-MuLV integrase by crosslinking. Biol Res. 41(1):69-80.

Coté ML, Roth MJ.(2008) Murine leukemia virus reverse transcriptase: structural comparison with HIV-1 reverse transcriptase. Virus Res. 134(1-2):186-202.

Schneider WM, Zheng H, Coté ML, Roth MJ. (2008) The MuLV 4070A G541R Env mutation decreases the stability and alters the conformation of the TM ectodomain. Virology. 371(1):165-74.

Sarangi A, Bupp K, Roth MJ. (2007) Identification of a retroviral receptor used by an envelope protein derived by peptide library screening. Proc Natl Acad Sci U S A. 104(26):11032-7.

Montano SP, Cote ML, Roth MJ, Georgiadis MM. (2006) Crystal structures of oligonucleotides including the integrase processing site of the Moloney murine leukemia virus. Nucleic Acids Res. 34(19):5353-60.

Puglia J, Wang T, Smith-Snyder C, Cote M, Scher M, Pelletier JN, John S, Jonsson CB, Roth MJ. (2006) Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteins. J Virol. 80(19):9497-510.

Bupp K. Sarangi A. Roth MJ. (2006) Selection of feline leukemia virus envelope proteins from a library by functional association with a murine leukemia virus envelope. Virology. 351(2):340-8.

Bupp K. Roth MJ. (2005) Alteration and analyses of viral entry with library-derived peptides. Adv Virus Res. 65:147-72.

Bupp. K. Sarangi. A. and Roth. MJ (2005) Probing sequence variation in the receptor-targeting domain of feline leukemia virus envelope proteins using peptide display libraries. J. Virol. 79:1463-1469.

Sunigo. R. Sengupta. S. Snyder. C. Leon. O and Roth. MJ(2004) Expression of the C-terminus of HIV-1 reverse transcriptase P66 and P51 subunits as a single polypeptide with RNase H activity. Protein Engineering. Design and Selection 17: 581-587. (Cover)

Guaitiao. JP. Zúñiga. RA. Roth. MJ and Leon. O (2004) Lysine directed crosslinking of viral RNA/DNA hybrid substrate to the isolated RNase H domain of HIV-1 reverse transcriptase. Biochemistry 43: 1302-8.

Bupp K and Roth. MJ (2003) Targeting a retroviral vector in the absence of a known cell-targeting ligand. Human Gene Therapy 14(16) 1557-64.
Villanueva. RA. Campbell. S. and Roth. MJ (2003) Molecular analysis of a recombinant M-MuLV-RaLV retrovirus. Virology 314:195-208.

Villanueva. RA. Jonsson. CB. Jones. J. Georgiadis. MM and Roth. MJ (2003) Differential multimerization of Moloney murine leukemia virus integrase purified under non-denaturing conditions. Virology 316:146-160.

O'Reilly. L and Roth. MJ (2003) G541R within the 4070A TM protein regulates fusion in Murine Leukemia Viruses. J. Virol 77:12011-12021.

Lu. C. -W. . O'Reilly. L. and Roth. M. J. (2003) G100R mutation within 4070A MuLV Env increases virus receptor binding. kinetics of entry. and viral transduction efficiency. J. Virol:77:739-743.

Lu. C.-W. and Roth. M. J. (2003) Functional interaction between the N- and C-terminaldomains of murine leukemia virus surface Envelope protein. Virology:310:130 - 140.

O'Reilly. L. and Roth. M. J. (2003) Identification of conformational and cold-sensitive mutations in the MuLV Envelope protein. Virology:312:337-49.

Yang. F. . Belitsky. J. M. . Villanueva. R. A.. Dervan. P. B. and Roth. M. J. (2003) Inhibition of Moloney murine leukemia virus integration using polyamides targeting the long-terminal repeat (LTR) sequences. Biochemistry 42(20):6249-58.

Lu. C. -W. and Roth. M. J. (2003) The role of Q252R in activating membrane fusion in the murine leukemia virus surface Envelope protein. J. Virol. 77: 10841-10849.

Bupp. K. and Roth. M. J. (2002) Altering retroviral tropism using a random display Envelope library. Molecular Therapy 5:329-335.

Seamon. J. A.. Jones. K. S.. Miller. C. and Roth. M. J. (2002) Inserting a nuclear targeting signal onto a replication-competent M-MuLV affects viral export and is not sufficient for cell cycle independent infection. J. Virol. 76: 8475-8484.

Yang. F. and Roth. M. J. (2001) Assembly and catalysis of concerted two-end integration events by Moloney murine leukemia virus. J. Virol 75:9561-9570.

Yang. F. . Seamon. J. A. and Roth. M. J. (2001) Mutational analysis of the N-terminus of Moloney murine leukemia virus integrase. Virology 291:32-45.

Gu. J.. Villanueva. R. A.. Synder. C. S.. Roth. M. J. and Georgiadis. M. M. (2001) Substitution of Asp 114 or Arg 116 in the fingers domain of Moloney murine leukemia virus reverse transcriptase affects interactions with the primer-template resulting in decreased processivity. J. Mol. Biol. 305:341-359.

Lu. C.-W. and Roth. M. J. (2001) Functional characterization of the N-terminus of murine leukemia virus Envelope proteins. J. Virol. 72:4357-4366.

Snyder. C.S. and Roth. M. J. (2001) Retroviral RNase H. Methods in Enzymology. (Academic Press. San Diego. CA) Allen W. Nicholson. editor. Vol.341 Part A. pp. 440-452.