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Loren W. Runnels, Ph.D.

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Selected Publications:

Runnels, L.W., Yue,  L., and D.E. Clapham. TRP-PLIK, a bifunctional  protein with Kinase and Ion Channel Activities. Science. 2001; 291(5506): 1043-1047.

Runnels, L.W., Yue, L., and D.E. Clapham. The TRPM7 channel is inactivated by PIP2 hydrolysis.” Nature. Cell Biology. 2002; 4(5):329-36.

Su, L-T., Agapito, M., Li, M., Simpson, W., Huttenlocher, A., Habas, R.Yue, L., and L.W. Runnels. TRPM7 Regulates Cell Adhesion by Controlling the Calcium Dependent Protease Calpain. J. Biol. Chem. 2006; 282(35):  25817-30

Sato, A., Khadka, D., Liu, W., Bharti, R., Runnels, L.W., Dawid, I.G., and R. Habas. Profilin Is An Effector For Daam1 In Non-Canonical Wnt Signaling and Is Required For Vertebrate Gastrulation.  Development. 2006; 133(21):4219-31.

Li, M., Du, J., Jiang, J. Ratzan, W.J., Su, L.T., Runnels, L.W., and L. Yue. Molecular Determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7. J. Biol Chem. 2007; 282(35):25817-30.

Sato, A., Liu, W., Bharti, R., Runnels, L.W. and R. Habas. Mechanism of activation of the Formin protein Daam1.  Proc. Nat. Acad. Sci. 2008; 105(1):  210-5.

Su, L-T., Chen, H-C., Pagán, O.G., Overton, J.S. Xie, J., Yue, L. and L.W. Runnels. 2010. TRPM7 activates m-calpain by stress-dependent Stimulation of p38 MAPK and c-Jun N-terminal kinase (JNK).  Journal of Molecular Biology.  396(4):  858-69.

Chen, H-C., Zhang, Z., Xie, J., Su, L-T., Yue, L. and L.W. Runnels. 2010. Blockade of TRPM7 Channel Activity and Cell Death by Inhibitors of 5-Lipoxygenase.  PLoS ONE. 5(6):e11161.

Aisiku, O., Philip, F., Guo, Y., Runnels, L.W., and S. Scarlata. 2010. Phospholipase Cb1 is linked to RNA interference through specific binding to translin-associated factor X. PloS ONE. 5(11):e15001.

Liu, W., Su, L-T., Khadka, D.K., Mezzacappa, C., Sato, A., Habas, R., and L.W. Runnels. 2011. TRPM7 Regulates Gastrulation During Vertebrate Embyrogenesis. Developmental Biology. (2):348-57.  

Su, L-T., Liu, W, Pagán, O.G., Chen, H-C. and L.W. Runnels. 2011. TRPM7 Regulates Polarized Cell Movements.  Biochemical Journal.   434(3):513-21.

Liu, W., Komiya, Y. Mezzacappa, C. Khadka, D.K., Runnels, L., and R. Habas.  2011.  MIM regulates vertebrate neural tube closure.  Development. 138(10):2035-47.

Tsai, Y.C., Pestka, S., Wang, L.H., Runnels, L.W., Lyu, Y.L., Liu, L.F.  2011.  Interferon-b Signaling Contributes to Ras Transformation.  PloS ONE.  6(8):e24291.

Xie, J., Sun, B., Du, J., Yang, W., Chen, H.C., Overton, J.D., Runnels, L.W., and L. Yue. 2011. “Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity.” Sci Rep. 2011; 1(146).  Doi: 10.1038/srep00146. 

Chen, H-C., Su, L-T., Liu, W, Pagán, O.G., Overton, J.D. and L.W. Runnels. 2012. “A Key Role for Mg2+ in TRPM7’s Control of ROS Levels During Cell Stress” Biochemical Journal.   Doi:10.1042/BJ20120248