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Alexey G. Ryazanov, Ph.D.



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Selected Publications:


Ryazanova LV, Rondon LJ, Kelly J, Zierler S, Hu Zhixian, Galli Joanna, Yamaguchi TP, Mazur A,  Fleig A, Ryazanov AG.  TRPM7 is essential for Mg2 homeostasis in mammals. Nature Communications. 2010 Nov;1(8):109.

Khan AA, Dace DS, Ryazanov AG, Kelly J, Apte RS.  Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. Am J Pathol. 2010 Jul; 177(1):481-92. Epub 2010 May 14.

Clark K, Middelbeek J, Dorovkov MV, Figdor CG, Ryazanov AG, Lasonder E, van Leeuwen FN.  The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.  FEBS Lett. 2008 Sep 3; 582(20): 2993-2997. Epub 2008 Aug 7.

Park S, Park JM, Kim S, Kim JA, Shepherd JD, Smith-Hicks CL, Chowdhury S, Kaufmann W, Ryazanov AG, Huganir RL, Leiden DJ, Worley PF. Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGlu-LTD. Neuron 2008 Jul 10; 59(1):70-83.

Clark K, Middlebeek J, Lasonder E, Dulyaninova NG, Morrice NA, Ryazanov AG, Bresnick AR, Figdor CG, and van Leeuwen FN. TRPM7 regulates myosin llA filament stability and protein localization by heavy chain phosphorylation. J. Mol. Biol. 2008 May 9; 378(4):790-803. Epub 2008 Mar 4.

Boyce M, Py BF, Ryazanov AG, Minden JS, Long K, Ma D, and Yuan J. A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. Cell Death Differ. 2008 Mar; 15(3):589-599. Epub 2008 Jan 11.

Hars ES, Qi H, Ryazanov AG, Jin S, Cai L, Hu C, Liu LF. Autophagy regulates ageing in C. elegans. Autophagy 2007 Mar-Apr; 3(2):93-5. Epub 2007 Mar 30.

Clark K, Langeslag M, van Leeuwen B, Ran L, Ryazanov AG, Figdor CG, Moolenaar WH, Jalink K, van Leeuwen FN.   TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J. 2006 Jan 25; 25(2):290-301. Epub 2006 Jan 12.

Schmitz C, Dorovkov MV, Zhao X, Davenport BJ, Ryazanov AG, Perraud AL. The channel kinases TRPM6 and TRPM7 are functionally nonredundant.  J Biol Chem. 2005 Nov 11; 280(45):37763-71. Epub 2005 Sep 2.

Hermosura MC, Nayakanti H, Dorovkov MV, Calderon FR, Ryazanov AG, Haymer DS, Garruto RM.  A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. Proc Natl Acad Sci U S A. 2005 Aug 9; 102(32):11510-5. Epub 2005 Jul 28.

Heine M, Cramm-Behrens CI, Ansari A, Chu HP, Ryazanov AG, Naim HY, Jacob R. Alpha-kinase 1, a new component in apical protein transport. J Biol Chem. 2005 Jul 8; 280(27):25637-43. Epub 2005 May 9.

Dorovkov MV, and Ryazanov AG. Phosphorylation of Annexin I by TRPM7 Channel-Kinase. J. Biol. Chem. 2004 Dec 3; 279(49): 50643-50646.  Epub 2004 Oct 12. 

Drennan D, Ryazanov AG.  Alpha-kinases: analysis of the family and comparison with conventional protein kinases.  Prog Biophys Mol Biol. 2004 May; 85 (1):1-32.

Ryazanova LV, Dorovkov MV, Ansari A, Ryazanov AG.  Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. J Biol Chem. 2004 Jan 30; 279(5):3708-16. Epub 2003 Oct 30.

Dorovkov MV, Pavur KS, Petrov AN, Ryazanov AG. Regulation of elongation factor-2 kinase by pH. Biochemistry 2002 Nov 12; 41(45):13444-50.

Ryazanov AG. Elongation factor-2 kinase and its newly discovered relatives. FEBS Lett.  2002 Mar 6; 514(1): 26-29.

Ryazanov AG, Nefsky BS. Protein turnover plays a key role in aging. Mech. Ageing Dev. 2002 Jan; 123(2-3), 207-213.

Ryazanova LV, Pavur KS, Petrov AN, Dorovkov MV and Ryazanov AG. Novel type of signaling molecules: protein kinases covalently linked with ion channels. Mol. Biol. (Mosk) 2001 Mar-Apr; 35(2): 321-32.

Alberdi F, Dadone J, Ryazanov A, Isenberg DA, Ravirajan C, Reichlin M.  Cross-reaction of lupus anti-dsDNA antibodies with protein translation factor EF-2. Clin Immunol. 2001 Feb; 98(2):293-300.

Pavur KS, Petrov AN, Ryazanov AG.  Mapping the functional domains of elongation factor-2 kinase. Biochemistry 2000 Oct 10; 39(40):12216-12224.

Tavernarakis N, Wang SL, Dorovkov M, Ryazanov A, Driscoll M.  Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nat Genet. 2000 Feb; 24(2):180-3.