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Yufang Shi, Ph.D.


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Shi Y.,  Du, L., Lin, L., and Wang, Y. 2015.  Targeting Mesenchymal Stem Cells: New Anti-Cancer Strategies. Nature Reviews Drug Discovery, in press.


Wang Y, Chen X, Cao W, Shi Y. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications.  Nature Immunology. 2014 Nov. 15 (11).  In press.


Zhang M, Zhou H, Zheng C, Xiao J, Zuo E, Liu W, Xie D, Shi Y, Wu C, Wang H, Li D, Li J. The roles of testicular c-kit positive cells in de novo morphogenesis of testis. Science Reports. 2014 Aug 4;4:5936.


Yin S, Yang J, Lin B, Deng W, Zhang Y, Yi X, Shi Y, Tao Y, Cai J, Wu CI, Zhao G, Hurst LD, Zhang J, Hu L, Kong X. Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients. Science Reports. 2014 Aug 12;4:6036.


Shi Y. The 1000th publication features protection of normal cells during chemotherapy: a land mark for Cell Death & Disease. Cell Death and Disease (2014) 5, e1062; doi:10.1038/cddis.2014.50


Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Cao K, Chen Q, Xu G, Zhang Y, Zhang J, Schneider RJ, Qian Y, Wang Y, Brewer G, Shi Y. Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell Death Differ. 2014 Jul 18. doi: 10.1038/cdd.2014.85.


Ma S, Xie N, Li W, Yuan B, Shi Y*, Wang Y*. Immunobiology of mesenchymal stem cells. Cell Death Differ. 2014 Feb;21(2):216-25.


Zhang Y, Cai W, Huang Q, Gu Y, Shi Y, Huang J, Zhao F, Liu Q, Wei X, Jin M, Wu C, Xie Q, Zhang Y, Wan B, Zhang Y. Mesenchymal stem cells alleviate bacteria-induced liver injury in mice by inducing regulatory dendritic cells. Hepatology. 2014 Feb;59(2):671-82.


Zhu K, Zhang N, Guo N, Yang J, Wang J, Yang C, Yang C, Zhu L, Xu C, Deng Q, Zhu R, Wang H, Chen X, Shi Y, Li Y, Leng Q. SSC(high)CD11b(high)Ly-6C(high)Ly-6G(low) myeloid cells curtail CD4 T cell response by inducible nitric oxide synthase in murine hepatitis. Int J Biochem Cell Biol. 2014 Jul 15;54C:89-97. doi: 10.1016/j.biocel.2014.07.005.


Yang X, Han ZP, Zhang SS, Zhu PX, Hao C, Fan TT, Yang Y, Li L, Shi Y, Wei LX. Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-β1 generation. Cell Death Dis. 2014 Jun 26;5:e1308. doi: 10.1038/cddis.2014.257.


Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X. A microRNA miR-221- and miR-222-mediated feedback loop, via PDLIM2, maintains constitutive activation of nuclear factor κB and STAT3 in colorectal cancer cells. Gastroenterology. 2014 Jun 12. pii: S0016-5085(14)00744-6. doi: 10.1053/j.gastro.2014.06.006.


Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y, Jiang Y, Su B, Wang H. Autocrine IL-6 drives skin-derived mesenchymal stem cell trafficking via regulating voltage-gated Ca(2+) channels. Stem Cells. 2014 Oct;32(10):2799-810. doi: 10.1002/stem.1763.


Cao G, Yang Q, Zhang SY, Xu CL, Roberts, AI, Wang Y, Shi YF. Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4. Brain, Behavior and Immunity. 2014 May;38:125-32. doi: 10.1016/j.bbi.2014.01.013. Epub 2014 Jan 27.


Chen X, Gan Y, Li W, Su J, Zhang Y, Huang Y, Roberts AI, Han Y, Li J, Wang Y,  Shi Y. The interaction between mesenchymal stem cells and steroids during inflammation. Cell Death Dis. 2014 Jan 23;5:e1009. doi: 10.1038/cddis.2013.537.


Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson AB, Roberts AI, Wang Y, Shi Y. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res. 2014 Jan 22.


Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi  Y, Iwakura Y, Qian Y. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity. 2014 Jan 16;40(1):140-52.


Xu C, Yu P, Han X, Du L, Gan J, Wang Y, Shi Y. TGF-β Promotes Immune Responses in the Presence of Mesenchymal Stem Cells. J Immunol. 2014 Jan 1;192(1):103-9. doi: 10.4049/jimmunol.1302164. Epub 2013 Nov 29.


Ren G, Liu Y, Zhao X, Zhang J, Zheng B, Yuag Z, Zhang L, Tischfield J, Shao C, Shi Y. Tumor resident mesenchymal stromal cells endow naïve stromal cells with tumor-promoting properties. Oncogene. 2014 Jul 24;33(30):4016-20. doi: 10.1038/onc.2013.387. Epub 2013 Sep 30.


Huang Y, Yu P, Li W, Ren G, Roberts, AI, Cao W, Zhang X, Su J, Chen X, Chen Q, Shou P, Xu C, Du L, Lin L, Zhang L, Xie N, Wang Y and Shi Y. p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation. Oncogene. 2014 Jul 17;33:3830-3838. doi: 10.1038/onc.2013.355. Epub 2013 Aug 26.


Su J, Chen X, Huang Y, Li W, Li J, Cao K, Cao G, Zhang L, Li F, Roberts AI, Kang H, Yu P, Ren G, Ji W, Wang Y, Shi Y. Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species. Cell Death Differentiation. 2014 Mar;21(3):388-96. doi: 10.1038/cdd.2013.149. Epub 2013 Oct 25.


Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, Roberts AI, Rabson AB, Ren G, Zhang Y, Wang Y, Denhardt DT, Shi Y. An Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells. 2014 Feb;32(2):327-37. doi: 10.1002/stem.1567.


Hou J, Han ZP, Jing YY, Yang X, Zhang SS, Sun K, Hao C, Meng Y, Yu FH, Liu XQ, Shi YF, Wu MC, Zhang L, Wei LX. Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells. Cell Death Dis. 2013 Oct 10;4:e844. doi: 10.1038/cddis.2013.338.


Xu C, Lin L, Cao G, Chen Q, Shou P, Huang Y, Han Y, Wang Y, Shi Y. Interferon-α-secreting mesenchymal stem cells exert potent antitumor effect in vivo. Oncogene. 2013 Nov 4. doi: 10.1038/onc.2013.458. [Epub ahead of print]


Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, Shi Y, Siebenlist U, Zhang X. Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development. PLoS One. 2013, 8:e75222.


Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, Shi Y, Siebenlist U, Zhang X. Correction: Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development. PLoS One. 2013, Nov 11;8.


Zhang J, Liu C, Roberts AI, Xu G, REN G, Zhang L, Devadas S and Shi Y. A novel subset of helper T cells promotes immune responses by secreting GM-CSF. Cell Death & Differentiation. 2013, 20:1731-1741.


Wu Q, Wang H, Zhao X, Shi Y, Jin M, Wan B, Xu H, Cheng Y, Ge H, Zhang Y. Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma. Oncogene. 2013, July 15. doi: 10.1038/onc.2013.264. [Epub ahead of print]


Yu B, He Z, You P, Han Q, Xiang D, Chen F, Wang M, Liu C, Lin X, Borjigin U, Zi X, Li J, Zhu H, Li W, Han C, Wangensteen KJ, Shi Y, Hui L, Wang X, Hu Y. Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors. Cell Stem Cell. 2013, 13:328-340.


Liu B, Chen X, Wang Y, Shi Y. Curative effect of hepatic portal venous administration of autologous bone marrow in AIDS patients with decompensated liver cirrhosis. Cell Death Disease  2013, 4:e739.


Phinney DG, Galipeau J, Krampera M, Martin I, Shi Y, Sensebe L. MSCs: science and trials. Nature Medicine 2013, 19:812-812.


Wei X, Yang X, Han Z, Qu F, Shao L, Shi Y. Mesenchymal stem cells: a new trend for cell therapy. Acta Pharmacologica Sinica. 2013, 34,747-754.


Xu C, Ren G, Cao G, Chen Q, Shou P, Zheng C, Du L, Han X, Jiang M, Yang Q, Lin L, Wang G, Yu P, Zhang X, Cao W, Brewer G, Wang Y, Shi Y. MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. Journal of Biological Chemistry 2013, 288:11074–11079.


Krampera M, Galipeau J, Shi Y, Tarte K, Sensebe L. Immunological characterization of multipotent mesenchymal stromal cells - The International Society for Cellular Therapy (ISCT) working proposal. Cytotherapy. 2013, 15(9):1054-61.


Wu X, Chesoni S, Rondeau G, Tempesta C, Patel R, Charles S, Daginawala N, Zucconi BE, Kishor A, Xu G, Shi Y, Li ML, Barreto PI, Welsh J, Wilson GM, Brewer G. Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs. Nucleic Acids Research 2013, 41:2644-2658.


Yang X, Hou J, Han Z, Wang Y, Hao C, Wei L, Shi Y. One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment. Cell & Bioscience 2013, 3:5-10.


Liu Z, Jiang Y, Hou Y, Hu Y, Cao X, Tao Y, Xu C, Liu S, Wang S, Wang L, Shi Y, Siebenlist U, Zhang X. The IκB family member Bcl-3 stabilizes c-Myc in colorectal cancer. Journal of Molecular Cell Biology 2013, 5: 280-282.


Zeng A, Li Y, Wang C, Han X, Li G, Wang JY, Li D, Qin Y, Shi Y, Brewer G, Jing Q. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. The Journal of Cell Biology 2013, 201:409-425.


Lang JY, Shi Y, Chin YE. Reprogramming cancer cells: back to the future. Oncogene. 2013 May 2;32(18):2247-8. doi: 10.1038/onc.2012.349. Epub 2012 Aug 6.


Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan Z, Roberts A, Zhang L, Zheng B, Wen T, Han Y, Rabson A, Tischfield J, Shao C, Shi Y. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell 2012, 11:812-824.


Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y. TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation. Molecular and Cellular Biology 2012, 32:3925-3937.


L’huillier A, Ren G, Shi Y, Zhang J. A two-hit model of autoimmunity: lymphopenia and unresponsiveness to TGF-β signaling. Cellular & Molecular Immunology 2012, 9:369-370.


Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley JB, Shen N, Qian Y. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nature Medicine 2012, 18:1077-1086.


Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res 2012, 22:836-847.


Li W, Ren G, Huang Y, Su J, Han Y, Li J, Chen X, Cao K, Chen Q, Shou P, Zhang L, Yuan ZR, Roberts AI, Shi S, Le AD, Shi Y. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ 2012, 19:1505-1513.


Han Z, Jing Y, Zhang S, Liu Y, Shi Y, Wei L. The role of immunosuppression of mesenchymal stem cells in tissue repair and tumor growth. Cell & Bioscience 2012, 2:8.

Shi Y, Su J, Roberts AI, Shou P, Rabson AB, Ren G. How mesenchymal stem cells interact with tissue immune responses. Trends in Immunology 2012, 33:136-143.

Sensebé L, Tarte K, Galipeau J, Krampera M, Martin I, Phinney DG, Shi Y. Limited Acquisition of Chromosomal Aberrations in Human Adult Mesenchymal Stromal Cells. Cell Stem Cell 2012, 10:9-10.


Shi Y, Wei L, Wang Y, Ren G. Stem Cells Deployed for Bone Repair Hijacked by T Cells. Cell Stem Cell. 2012, 10:6-8.


Ren G, Chen X, Dong F, Li W, Ren X, Zhang Y, Shi Y. Concise review: mesenchymal stem cells and rranslational medicine: emerging issues. Stem Cells Transl Med. 2012, 1:51-58.


Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nunez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death and Differentiation 2012, 19:107-120.


Han Z, Tian Z, Lv G, Zhang L, Jiang G, Sun K, Wang C, Bu X, Li R, Shi Y, Wu M, Wei L. Immunosuppressive effect of bone marrow‐derived mesenchymal stem cells in inflammatory microenvironment favours the growth of B16 melanoma cells. J Cell Mol Med. 2011, 15:2343-2352.


Shi P, Zhu S, Lin Y, Liu Y, Liu Y, Chen Zn, Shi Y, Qian Y. Persistent Stimulation with Interleukin-17 Desensitizes Cells Through SCFβ-TrCP-Mediated Degradation of Act1. Sci Signal 2011, 4:ra73.


Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nature Immunol 2011 Oct 12;12(12):1151-8.


Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C, Zhang JZ. Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease. Immunity2011, 35:273-284.


Krause CD, Izotova LS, Ren G, Yuan ZR, Shi Y, Chen CC, Ron Y, Pestka S. Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid. Stem Cell Research & Therapy 2011, 2:1-20.


Yamaza T, Ren G, Akiyama K, Chen C, Shi Y, Shi S. Mouse mandible contains distinctive mesenchymal stem cells. Journal of Dental Research 2011, 90:317-324.


Zhao F, Zhang Y, Wang H, Jin M, S, He S, Shi Y, Guo Y and Zhang Y. Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease. Blood2011, 179:1723-33.


Ren G, Roberts AI, Shi Y. Adhesion molecules: key players in mesenchymal stem cell-mediated immunosuppression. Cell Adhesion & Migration 2011, 5:20-22.


Hu G, Ren G, Shi Y. The putative cannabinoid receptor GPR55 promotes cancer cell proliferation. Oncogene2011, 30:139-141.


Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, Liu Y, Zhao L, Li X, Shi Y, Qian Y. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med 2010, 207:2647-62.


Swaims AY, Khani F, Zhang Y, Roberts AI, Devadas S, Shi Y*, Rabson AB*. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T-cells. Blood. 2010 Oct 21;116(16):2994-3003. (*equal contribution)


Arriola A, Kiel ME, Shi Y, McKinnon RD. Adjunctive MSCs enhance myelin formation by xenogenic oligodendrocyte precursors transplanted in the retina. Cell Res. 2010, 20:728-31.


Shi YF, Hu GZ, Su JJ, Li WZ, Chen Q, Shou PS, Xu CL, Chen XD, Huang Y, Zhu ZX, Huang X, Han XY, Xie NX, Ren GW. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res. 2010, 20: 519-528.


Ye W, Gong X, Xie J, Wu J, Zhang X, Ouyang Q, Zhao X, Shi Y, Zhang X. AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion. Apoptosis. 2010, 15:474-87.


Yamaza T, Kentaro A, Chen C, Liu Y, Shi Y, Gronthos S, Wang S, Shi S. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther. 2010, 1:5.


Ren GW, Zhao X, Zhang LY, Zhang JM, L’Huillier A, Ling WF, Roberts AI, Le AD, Shi ST, Shao CS, and Shi YF. Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression. J Immunol. 2010, 184:2321-2328.


Markovina S, Callander NS, O´Connor SL, Xu G, Shi Y, Leith CP, Kim K, Trivedi P,

Kim J, Hematti P, Miyamoto S. Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells. Mol Cancer. 2010, 9:176-188.


Zhao X, Ren GW, Liang L, Zheng B, Tischfield JA, Shi YF, Shao CS. Brief report: IFN-γ induces expansion of Lin-Sca-1+C-Kit+ Cells. Stem Cells. 2010, 28: 122-126.


Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, Le AD. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. The Journal of Immunology 2009, 183:7787-7798.


Das J, Ren GW, Zhang LY, Roberts IA, Zhao X, Bothwel ALM, Kaer LV, Shi YF, Das G. Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 2009 Oct 29;206(11):2407-16.


Izotova LS, Krause CD, Ren G, Yuan ZR, Shi Y, Pestka S. PP2-014 Visualizing engineered interferon-producing cells with multicistronic vectors and fluorescent proteins. Abstracts/Cytokine  2009, 48:91-137.


Kong L, Sun L, Zhang H, Liu Q, Liu Y, Qin L, Shi G, Hu JH, Xu A, Sun YP, Li D, Shi YF, Zang JW, Zhu J, Chen Z, Wang ZG, Ge BX. An essential role for RIG-I in toll-like receptor-stimulated phagocytosis. Cell Host Microbe (by Cell Press) 2009, 6:150-161.


Ren G, Su J, Zhang L, Zhao X, Ling W, L´huillie A, Zhang J, Lu Y, Roberts AI, Ji W, Rabson AB, Shi YF. Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression. Stem Cells. 2009, 27:1954-1962.


Shi Y, Zhu J, Salomoni P, Tucci P, Lu X. A Sino-British frontier workshop of cancer biology. Cell Death & Differentiation 2009, 16:648-650.

Vavassori S, Shi Y, Chen CC, Ron Y, Covey LR. In vivo post-transcriptional regulation of CD154 in mouse CD4+ T cells. Eur J Immunol 2009, 39:2224-2232.


Xu G, Zhang Y, Zhang L, Roberts, A.I., Shi YF. C/EBPβ Mdiates the Synergistic Upregulation of Gene Expression by IFN-γ and TNF-α in Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells. 2009, 27:942-984.


Wang KX, Shi YF, Ron Y, Kazanecki CC, Denhardt DT. Plasma osteopontin modulates chronic restraint stress-induced thymus atrophy by regulating stress hormones: inhibition by an anti-osteopontin monoclonal antibody. Journal of Immunology 2009, 182:2485-2491.


Qian Y, Shi Y. Natural killer cells go inside: entosis versus cannibalism. Cell Res. 2009; 9:1320-1321.


Xu G, Zhang Y, Zhang L, Ren G, Shi YF. Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing nitric oxide. Biochem Biophys Res Commun. 2008, 375: 666-670.


Ren GW, Su JJ, Zhao X, Zhang LY, Zhang JM, Roberts AI, Zhang HT, Das G, Shi YF. Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide. Journal of immunology. 2008, 181: 3277-84.


Zhao RC, Zhu YS, Shi YF. New Hope for Cancer Treatment: exploring the distinction betweennormal adult stem cells and cancer stem cells. Pharmacology and Therapeutics. 2008, 119: 74-82.


Zhang YY, Xu GW, Zhang LY, Roberts AI, Shi YF. Th17 Cells Undergo Fas-mediated Activation-induced Cell Independent of IFN-γ. J. Immunol. 2008, 181: 190-196.


Yuan ZR and Shi YF. Chloramphenicol induces abnormal cell differentiation and inhibits apoptosis in activated T cells: possible links to leukemogenesis. Cancer Research. 2008, 68: 4875-4881.


Zhang J, Jiang H, Gao W, Wu J, Peng K, Shi Y, Zhang X. The JNK/AP1/ATF2 pathway is involved in H 2 O 2-induced acetylcholinesterase expression during apoptosis. Cell Mol Life Sci 2008, 65:1435-1445.


Shi YF and August DA. A New Trick for an Old Drug: mTOR Inhibitor Rapamycin Augments the Effect of Fluorouracil on Hepatocellular Carcinoma through Inducing Cell Senescence. Commentary. Cancer Biology and Therapeutics. 2008, 7:397-8.


Ren GW, Zhang LY, Zhao X, Xu GW, Zhang YY, Roberts AI, Zhao RC, and Shi YF. Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide. Cell Stem Cell (by Cell Press). 2008, 2: 141-150.


Zhu H, Gao W, Jiang H, Jin QH, Shi YF, Tsim KW, Zhang XJ. Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis. Int J Biochem Cell Biol. 2007, 39: 93-108.


Zhu H, Gao W, Shi YF, Zhang XJ. The CCAAT-binding factor CBF/NF-Y regulates the human acetylcholinesterase promoter activity during calcium ionophore A23187-induced cell apoptosis. Biochim Biophys Acta-General Subjects. 2007, 1770: 1475-1482.


Chen L, Zhang W, Yue H, Han Q, Chen B, Shi M, Li J, Li B, You S, Shi Y, Zhao RC. Effects of human mesenchymal stem cells on the differentiation of dendritic cells from CD34+ cells. Stem Cells Dev. 2007, 16(5): 719-31.


Xu G, Zhang Y, Zhang L, Ren G, Shi Y. The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells. Biochem Biophys Res Comm. 2007, 361: 745-50.


Wang K, Desai B, Shi Y* and Denhardt DT*. Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy through modulating corticosteroid production. PNAS2007, 104:14777-14782.


Ehirchiou D, Amarnath S, Xiong Y, Xu G, Chen W, Shi Y and Zhang L. CD11b Facilitates the Development of Peripheral Tolerance by Suppressing Th17 Differentiation. J Exp Med. 2007, 204: 1519-24.


Xu GW and Shi YF. Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res. 2007, 17: 759-71.


Zhu H, Gao W, Jiang H, Wu J, Shi YF, Zhang XJ. Calcineurin mediates acetylcholinesterase expression during calcium ionophore A23187-induced HeLa cell apoptosis. Biochim Biophys Acta-Molecular Cell Res. 2007, 1773: 593-602.


Xu G, Zhang L, Ren G, Yuan Z, Zhang Y, Zhao R, Shi Y. Immunosuppressive properties of cloned bone marrow mesenchymal stem cells. Cell Res 2007, 17:240-248.


Das J, Eynott P, Van Kaer L, Das G* and Shi Y*. Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation. Nature Medicine 2006, 12:1345-1346.


Das G, Mittal J, Zhang YY, Bothwell A, Van Kare Luc, and Shi YF. Pivotal Roles of Major Histocompatibility Complex Class Ib Restricted CD8+ T Cells in Autoimmune Diseases. J Exp Med. 2006, 203: 2603-11.


Devadas S, Das J, Liu C, Zhang L, Roberts AI, Pan Z, Moore PA, Das G, Shi Y. Granzyme B is critical for T cell receptor-induced cell death of Type 2 helper T cells. Immunity2006, 25:237-247.


Shi Y, Roberts AI, Sun E. Dying T lymphocytes call for the death of tumor cells. Commentary. Cell Res. 2006, 16(8): 679-80.

Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C,


Shi Y, Gelinas C, Fan Y, Nelson DA, Jin S, White E. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell. 2006, 10: 51-64.


Devadas S, Liu C, Shi Y. Novel helper T cell subset helps other T cells through producing GM-CSF. The Journal of Immunology 2006, 176:S14-S15.


Shi YF and Devadas A. Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) and T-Cell Responses: What We Do and Don´t Know. Cell Res. 2006, 16: 126-33.


Yuan ZR, Wang RX, Lou XY, Zhang LY and Shi YF. Identification and Characterization of a Novel Cell Survival Gene Critical in Apoptosis and Tumorigenesis. Cancer Research. 2005, 65: 10716-24.


Greeneltch KM, Kelly-Welch AN, Keegan AD and Shi YF. Chronic Morphine Administration Promotes Th2 Differentiation via a Fas/FasL-Dependent Mechanism. J Immunol. 2005, 175: 4999-5005.


Greeneltch KM, Haudenschild CC, Keegan AD, Shi YF. The Opioid Antagonist Naltrexone Blocks Acute Endotoxic Shock by Inhibiting Tumor Necrosis Factor-a Production. Brain Behav Immun. 2004, 18: 476-84.


Sun EW, Gao Y, Chen JF, Roberts AI, Wang XN, Chen ZH, and Shi YF. Allograft Tolerance Induced by Donor Apoptotic Lymphocytes Requires Phagocytosis in the Recipient. Cell Death and Diff. 2004, 11: 1258-1264.


Jin QH, He HY, Shi YF, Lu H, Zhang XJ. Overexpression of acetylcholinesterase inhibited cell proliferation and promoted apoptosis in NRK cells. Acta Pharmacol Sin. 2004, 25: 1013-21.


Pestka S, Krause C, Sarkar D, Walter M, Shi YF, Fisher P. Interleukin-10 and related cytokines and receptors. Ann Rev Immunol. 2004, 22: 929-979.


Roberts AI, Devadas S, Zhang X, Zhang L, Keegan A, Greeneltch K, Solomon J, Wei L, Das J, Sun E, Liu C, Yuan Z, Zhou JN, Shi Y. The role of activation-induced cell death in the differentiation of T-helper-cell subsets. Immunologic Research 2003, 28:285-293.


Wei LX, Zhou JN, Roberts AI, Shi YF. Lymphocyte Reduction Induced by Hindlimb Unloading: Distinct Mechanisms in the Spleen and Thymus. Cell Res. 2003, 13: 465-71.


Shi YF, Devadas S, Greeneltch KM, Yin D, Allan Mufson R and Zhou J. Stressed to death: Implication of lymphocyte apoptosis for psychoneuroimmunology. Brain Behav Immun. 2003, 17: 18-26.


Solomon JC, Sharma K, Wei LX, Fujita T and Shi YF. A Novel Role for Sphingolipid Intermediates in Activation- Induced Cell Death in T-cells. Cell Death Differ. 2003, 10: 193-202.


Zhang XR, Zhang LY, Devadas S, Li L, Keegan AD and Shi YF. Reciprocal Expression of TRAIL and CD95L in Th1 and Th2 Cells: Role of Apoptosis in T Helper Subset Differentiation. Cell Death Differ. 2003, 10: 216-224.


Jin QH, Shi YF, He HY, Ng KK, Jiang H, Yang L, Jiang ZQ and Zhang XJ. Isolation of acetylcholinesterase from apoptotic human lung fibroblast cells by antibody affinity chromatography. Biotechniques. 2002, Suppl: 92-94.


Wang RX and Shi YF. A simplified protocol for apoptosis assay by DNA content analysis. Biotechniques. 2002, Suppl: 88-91.


Tonon G, Luo X, Greco NJ, Chen W, Shi YF and Jamieson GA. Weak platelet agonists and U46619 induce apoptosis-like events in platelets, in the absence of phosphatidylserine exposure. Thromb Res. 2002, 107: 345-350.


Zhang XJ, Yang L, Zhao Q, Caen JP, He HY, Jin QH, Guo LH, Alemany M, Zhang LY and Shi YF. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell Death Differ. 2002, 9: 790-800.


Li L, Qi X, Williams M, Shi YF and Keegan AD. Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation- induced cell death. J Immunol. 2002, 168: 6215-6223.


Wang R, Zhang L, Zhang X, Moreno J, Celluzzi C, Tondravi M and Shi YF. Regulation of activation-induced receptor activator of NF-kappaB ligand (RANKL) expression in T cells. Eur J Immunol. 2002, 32: 1090-1098.


Gao Y, Shuang W, Shi Y, Sun E. Permanent liver allograft survival induced by transfusion of apoptotic donor splenocyte without immunosuppression. Cell Res 2002, 12:272-273.


Sun EW and Shi YF. Apoptosis: the quiet death silences the immune system. Pharmacol Ther. 2001, 92: 135-145.


Gubina E, Luo X, Kwon E, Sakamoto K, Shi YF and Mufson RA. Betac cytokine receptor-induced stimulation of cAMP response element binding protein phosphorylation requires protein kinase C in myeloid cells: a novel cytokine signal transduction cascade. J Immunol. 2001, 167: 4303-4310.


Wang R, Zhang L, Zhang X, Moreno J, Luo X, Tondravi M and Shi YF. Differential regulation of the expression of CD95 ligand, receptor activator of nuclear factor-kappa B ligand (RANKL), TNF-related apoptosis-inducing ligand (TRAIL), and TNF-alpha during T cell activation. J Immunol. 2001, 166: 1983-1990.


Sharma K, Wang RX, Zhang LY, Yin DL, Luo XY, Solomon JC, Jiang RF, Markos K, Davidson W, Scott DW and Shi YF. Death the Fas way: regulation and pathophysiology of CD95 and its ligand. Pharmacol Ther. 2000, 88: 333-347.


Yin D, Tuthill D, Mufson RA and Shi YF. Chronic restraint stress promotes lymphocyte apoptosis by modulating CD95 expression. J Exp Med. 2000, 191: 1423-1428.


Yin D, Zhang L, Wang R, Radvanyi L, Haudenschild C, Fang Q, Kehry MR and Shi YF. Ligation of CD28 in vivo induces CD40 ligand expression and promotes B cell survival. J Immunol. 1999, 163: 4328-4334.


Sharma K and Shi YF. The yins and yangs of ceramide. Cell Res. 1999, 9: 1-10.

Yin D, Mufson RA, Wang R and Shi YF. Fas-mediated cell death promoted by opioids. Nature. 1999, 397: 218.


Su Y, Damjanovski S, Shi YF and Shi YB. Molecular and cellular basis of tissue remodeling during amphibian metamorphosis. Histol Histopathol. 1999, 14: 175-183.


Wang R, Brunner T, Zhang L and Shi YF. Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression. Oncogene. 1998, 17: 1503-1508.


Wang R, Zhang L, Yin D, Mufson RA and Shi YF. Protein kinase C regulates Fas (CD95/APO-1) expression. J Immunol. 1998, 161: 2201-2207.


Zamorano J, Wang HY, Wang R, Shi YF, Longmore GD and Keegan AD. Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression. J Immunol. 1998, 160: 3502-3512.


Su Y, Shi YF, Stolow MA and Shi YB. Thyroid hormone induces apoptosis in primary cell cultures of tadpole intestine: cell type specificity and effects of extracellular matrix. J Cell Biol. 1997, 139: 1533-1543.


Shi YF, Wang R, Sharma A, Gao C, Collins M, Penn L and Mills GB. Dissociation of cytokine signals for proliferation and apoptosis. J Immunol. 1997, 159: 5318-5328.


Liang FT, Granstrom DE, Timoney JF and Shi YF. Micropreparative high resolution purification of proteins by a combination of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, isoelectric focusing, and membrane blotting. Anal Biochem. 1997, 250: 61-65.


Shi YF, Hill M, Novak A, Chen ZQ, Wang RX, Liew CC and Mills GB. Human hematopoietic cell express two forms of the cytokine receptor common gamma-chain (gamma c). Cell Res. 1997, 7: 195-205.


Su Y*, Shi YF* and Shi YB. Cyclosporin A but not FK506 inhibits thyroid hormone-induced apoptosis in tadpole intestinal epithelium. Faseb J. 1997, 11: 559-565. (*equal contribution)

Wang R, Fang Q, Zhang L, Radvany L, Sharma A, Noben-Trauth N, Mills GB and

Shi YF. CD28 ligation prevents bacterial toxin-induced septic shock in mice by inducing IL-10 expression. J Immunol. 1997, 158: 2856-2861.


Liang T, Granstrom DE and Shi YF. Concentrating protein samples for sodium dodecyl sulphate-polyacrylamide gel electrophoresis and isoelectric focusing using protein-blotting membranes. J Chromatogr A. 1997, 764: 143-150.


Radvanyi LG, Shi YF, Mills GB and Miller RG. Cell cycle progression out of G1 sensitizes primary-cultured nontransformed T cells to TCR-mediated apoptosis. Cellular immunology. 1996, 170: 260-273.


Scott DW, Grdina T and Shi YF. T cells commit suicide, but B cells are murdered! J Immunol. 1996, 156: 2352-2356.(Cutting Edge)


Radvanyi LG*, Shi Y*, Vaziri H, Sharma A, Dhala R, Mills GB and Miller RG. CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response. The Journal of Immunology 1996, 156:1788-1798.


McGahon AJ, Martin SJ, Bissonnette RP, Mahboubi A, Shi YF, Mogil RJ, Nishioka WK and Green DR. The end of the (cell) line: methods for the study of apoptosis in vitro. Methods Cell Biol. 1995, 46: 153-185.


Shi YF*, Radvanyi LG*, Sharma A, Shaw P, Green DR, Miller RG and Mills GB. CD28-mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis. J Immunol. 1995, 155: 1829-1837. (*equal contribution)


Shi YF, Frankel A, Radvanyi LG, Penn LZ, Miller RG and Mills GB. Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro. Cancer Res. 1995, 55: 1982-1988.


Green DR, Mahboubi A, Nishioka W, Oja S, Echeverri F, Shi YF, Glynn J, Yang Y, Ashwell J and Bissonnette R. Promotion and inhibition of activation-induced apoptosis in T-cell hybridomas by oncogenes and related signals. Immunol. Rev. 1994, 142: 321-342.


Rabinovitch A, Suarez-Pinzon WL, Shi YF, Morgan AR and Bleackley RC. DNA fragmentation is an early event in cytokine-induced islet beta-cell destruction. Diabetologia. 1994, 37: 733-738.


Mogil RJ*, Shi YF*, Bissonnette RP, Bromley P, Yamaguchi I and Green DR. Role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo. J Immunol. 1994, 152: 1674-1683. (*equal contribution)


Mills GB, Schmandt R, Gibson S, Leung B, Hill M, May C, Shi YF, Branch DR, Radvanyi L, Truitt KE and et al. Transmembrane signaling by the interleukin-2 receptor: progress and conundrums. Semin Immunol. 1993, 5: 345-364.


Shi YF, Kornovski BS, Savani R and Turley EA. A rapid, multiwell colorimetric assay for chemotaxis. J Immunol Methods. 1993, 164: 149-154.


Helgason CD, Shi L, Greenberg AH, Shi YF, Bromley P, Cotter TG, Green DR and

Bleackley RC. DNA fragmentation induced by cytotoxic T lymphocytes can result in target cell death. Exp Cell Res. 1993, 206: 302-310.


Green DR, Bissonnette RP, Glynn JM and Shi YF. Activation-induced apoptosis in lymphoid systems. Semin Immunol. 1992, 4: 379-388.


Green DR, Zheng H and Shi YF. Antisense oligodeoxynucleotides as probes of T-lymphocyte gene function. Ann N Y Acad Sci. 1992, 660: 193-203.


Shi YF, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP and Green DR. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science. 1992, 257: 212-214. (with cover illustration)


Shi YF, Bissonnette RP, Parfrey N, Szalay M, Kubo RT and Green DR. In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J Immunol. 1991, 146: 3340-3346.


Shi YF, Szalay MG, Paskar L, Sahai BM, Boyer M, Singh B and Green DR. Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation. J Immunol. 1990, 144: 3326-3333.


Shi YF, Sahai BM and Green DR. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature. 1989, 339: 625-626.


Shi YF, Mahrt JL and Mogil RJ. Kinetics of murine delayed-type hypersensitivity response to Eimeria falciformis (Apicomplexa: Eimeriidae). Infect Immun. 1989, 57: 146-151.


Mahrt JL and Shi YF. Murine major histocompatibility complex and immune response to Eimeria falciformis. Infect Immun. 1988, 56: 270-271.


Books Chapters


Sun E, Zhang L, Roberts AI, Liu C and Shi Y. Chronic stress induced death of lymphocytes. Cytokines: Stress and Immunity, Second Edition, edited by Nicholas P Plotnikoff, Robert E Faith, Anthony J Murgo, and Robert A Good. 2005, CRC Press.


Shi Y, Devadas S, Zhang X, Zhang L, Keegan AD, Greeneltch K, Solomon JC, Yuan Z, Sun E, Liu C, Das J, Thayyil-Satish M, Wei L, Zhou J and Roberts AI. Activation-Induced Cell Death and T Helper Subset Differentiation. In Shi YF, Cidlowski J, Scott DW and Shi YB. (Eds.) Molecular Mechanisms of Programmmed Cell Death Kluwer Academic/Plenum Publishers, New York 2003.


Sun E and Shi Y. The mechanisms and significance of immune tolerance induced by apoptotic cells. In Shi YF, Cidlowski J, Scott DW and Shi YB. (Eds.). Molecular Mechanisms of Programmed Cell Death Kluwer Academic/Plenum Publishers, New York 2003.


Shi Y, Mills GB and Wang R. Mitogenic Cytokines Promote Apoptosis: Possible Roles in Cellular Homeostasis. In Shi YB, Shi YF, Scott DW and Xu YH. (Eds.) Current Advances in Programmed Cell Death Plenum Publishing Corp., New York 1997, pp 113-142.


Scott DW, Brunner T, Donjerkovic D, Ezhevsky S, Grdina T, Green DR, Shi Y and Yao X. Murder and suicide: A tale of T and B cell apoptosis. In Shi YB, Shi YF, Scott DW and Xu YH. (Eds.) Current Advances in Programmed Cell Death Plenum Publishing Corp., New York 1997, pp 91-103.


Shi Y and Wang R. In Li C, Guo Y, Yie Q and Tang X. (Eds.) Current Advance in Tumor Molecular Biology Medical Science Publisher, Beijing 1996, pp 61-69.


Scott DW, Ezhevksy S, Maddox B, Washart K, Yao X and Shi Y. Scenes from short life: checkpoints and progression signals for immature B-cell life versus apoptosis. In Rigley K, and Harnett M. (Eds.). John Wiley, Chichester, England. 1995, pp 165-175.


Green DR, Shi Y, Glynn JM, Mahboubi A and Mogil RJ. Myc, Fas, apoptosis, and immune tolerance. In: Apoptosis. In Mihich E and Schimke RT. (Eds.) Apoptosis Plenum Press, New York 1994, pp 213-222.


Bissonnette RP, Shi Y, Mahboubi A, Glynn JM. C-myc and apoptosis. Current Communications in Cell and Molecular Biology 1994, 327-327


Bissonnette RP, Shi YF, Mahboubi A, Glynn JM and Green DR. C-myc and apoptosis. In Tomei LD and Cope FO. (Eds.) Apoptosis II: The Molecular Basis of Cell Death Cold Spring Harbor Lab Press, Cold Spring Harbor, New York 1994, pp 327-335.


Green DR and Shi Y. In Malhotra SK. (Ed.) Advances in Structural Biology JAI Press, Inc. 1990, pp 287-299.


Wang R, Zhang L, Yin D, Mufson RA and Shi Y. . In Talwar GP, Nath I, Ganguly NK and Rao KVS. (Eds.) Proceedings of 10th International Congress of Immunology Monduzzi Editore, Bologna, Italy 1999, pp 499-505.


Books Edited

Shi, Y. B., Y. F. Shi, D. W. Scott, and Y. H. Xu. 1997. Current Advances in Programmed Cell Death. Plenum Publishing Corp., New York.

Shi, Y. F., J. Cidlowski, D. W. Scott, and Y. B. Shi. 2003. Molecular Mechanisms of Programmmed Cell Death. Kluwer Academic/Plenum Publishers, New York.

Liu, XY., Pestka, S. Shi, Y.F., Cidlowski, J.  2007 Selected Papers from the 2005 Annual Meeting of the International Society for Interferon and Cytokine Research (ISICR): Interferons and Cytokines.  Shanghai Scientific and Technical Publishers.

Liu, XY, Pestka, S and Shi, YF. Recent Advance in Cancer Research and Therapy, Elsevier 2012




Shi Y, Ren G, Zhang L. Kit containing stem cells and cytokines for use in attenuating immune responses.  US Patent number: 8685728, issued April 1, 2014