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News and Events
Graduate Student Research Seminar:

No program scheduled at this time


 

Rutgers RWJMS Basic Science Seminar Series:


Emerging Frontiers in Biomedical Research

No program scheduled at this time

 


Recent Publications:

 

SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation. 

Chi Kwan Tsang, Miao Chen, Xin Cheng, Yanmei Qi, Yin Chen, Ishani Das, Xiaoxing Li, Brinda Vallat, Li-Wu Fu, Chao-Nan Qian, Hui-Yun Wang, Eileen White, Stephen K. Burley, X.F. Steven Zheng.  2018 Molecular Cell 70, 502-515, May 3 2018

Interview with the Author: https://www.cell.com/molecular-cell/meet-the-author.

To Claim Growth Turf, mTOR Says SOD Off. 

Hyewon Kong and Navdeep S. Chandel. Maintaining redox balance in cancer cells is essential for tumor development and progression. In this issue of Molecular Cell, Tsang et al. (2018) identify an evolutionarily conserved mTORC1-dependent mechanism by which cancer cells control redox homeostasis in ischemic tumor microenvironment. 2018 Molecular Cell 70, 502-515, May 3 2018 

Article preview by Navdeep Chandel: https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30311-3

 

Pyocyanin Inhibits Chlamydia Infection by Disabling Infectivity of the Elementary Body and Disrupting Intracellular Growth.  

Li JL, Yang N, Huang L, Chen D, Zhao Y, Tang MM, Fan H, Bao X.  Antimicrob Agents Chemother. 2018 Apr 2. pii: AAC.02260-17. doi: 10.1128/AAC.02260-17. [Epub ahead of print]

 

Effect of mitochondrial uncouplers niclosamide ethanolamine (NEN) and oxyclozanide on hepatic metastasis of colon cancer.

Amer Alasadi, Michael Chen, G. V. T. Swapna, Hanlin Tao, Jingjing Guo, Juan Collantes, Noor Fadhil, Gaetano T. Montelione and Shengkan Jin.  Cell Death and Disease (2018) 9:215

 

Niclosamide piperazine prevents high-fat diet-induced obesity and diabetic symptoms in mice.

Guo J, Tao H, Alasadi A, Huang Q, Jin S. Eat Weight Disord. 2017 Aug 5. doi: 10.1007/s40519-017-0424-7. [Epub ahead of print]

 

β-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus.

Ferrer-González E, Kaul M, Parhi AK, LaVoie EJ, Pilch DS.   Antimicrob Agents Chemother. 2017 Jun 19. pii: AAC.00863-17. doi: 10.1128/AAC.00863-17. [Epub ahead of print]

 

Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ.

Fujita J, Maeda Y, Mizohata E, Inoue T, Kaul M, Parhi AK, LaVoie EJ, Pilch DS, Matsumura H.

ACS Chem Biol. 2017 Jul 21;12(7):1947-1955. doi: 10.1021/acschembio.7b00323. Epub 2017 Jun 16.

 

 

Recent Research Grants and Awards:

 

Daniel Herranz Benito, PhD, assistant professor of pharmacology, have been awarded a grant

in the amount of $100,000.00 for a period of one year from the Leukemia Research Foundation.

 

Daniel Herranz Benito, PhD, assistant professor of pharmacology, received a three-year, Transition Phase R00 Pathway to Independence Award from the NIH totaling $747,000 to explore "Functional Dissection of Oncogenic Enhancers." 

 

William Welsh, PhD, Norman H. Edelman Professor in Bioinformatics, Department of Pharmacology, was granted a $100,000 award from TechAdvance to facilitate commercialization of Rutgers Technologies for his First-in-Class Pan-TAM Tyrosine kinase inhibitors for cancer therapy.