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The Division of Cancer Bioinformatics and Surveillance

John J. Graff, PhD, MS
Chief of Cancer Bioinformatics and Surveillance
Associate Professor

Message from the Chief

Bioinformatics is a new discipline of science that organizes and translates the overwhelming amount of data recently available on living organisms as a result of the human genome project and follow-up projects. Cancer bioinformatics is now emerging as a new interdisciplinary field, which is facilitating an unprecedented synthesis of knowledge arising from the life and clinical sciences.

In this post-genomic era, a large amount of data such as expressed sequence tag (EST) data, structure data, microarray data, proteomic data, single nucleotide polymorphism (SNP) data and clinical data provide great opportunities to understand cancer, the second most common cause of death in the western world. Cancer bioinformatics takes these data and addresses the same problem from different angles and then integrates them to generate useful hypotheses to understand the mechanisms of cancer. The Division of Cancer Bioinformatics and Surveillance is engaged in large scale population studies which look at cancer as a system and seeks to identify weaknesses and vulnerabilities in the system.