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Wenwei Hu, Ph.D.

Assistant Professor
Division of Radiation Cancer Biology Tel: 732-235-6169 


Academic Appointments:

    • Assistant Professor

Research Interests:

    • P53
    • Tumor Suppressor
    • Single Nucleotide Polymorphism
    • Leukemia Inhibitory Factor

Selected Peer-Reviewed Publications :

  1. Bond G.L., Hu W. (co-first author), Bond E.E., Robins H., Lutzker S.G., Arva N.C., Bargonetti J., Bartel F., Taubert H., Wuerl P., Onel K., Yip L., Hwang S.J., Strong L.C., Lozano G., Levine A.J. (2004) A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell, 119:591-602.
  2. Feng Z., Hu W. (co-first author), Tang M.S.  (2004) Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci U S A, 101:8598-8602.
  3. Hu W., Feng Z., Teresky A., Levine A.J. (2007) p53 regulates maternal reproduction through LIF. (with commentary) Nature, 450:721-724.
  4. Hu W., Feng Z., Ma L., Wagner J., Rice J.J., Stolovitzky G., Levine A.J. (2007) A single nucleotide polymorphism in the Mdm2 gene disrupts the oscillation of p53 and Mdm2 levels in cells. Cancer Res., 67: 2057-2065.
  5. Hu W. (corresponding author) (2009) The role of p53 gene family in reproduction. CSH Perspectives in Biology, 1: 209-220. (PMC2882126)
  6. Kang H., Feng Z., Sun Y., Atwal G., Murphy M., Rebbeck T., Rosenwaks Z., Levine A.J., Hu W. (corresponding author) (2009) Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A, 106:9761-9766. (PMC2700980)
  7. Hu W., Zhang C, Wu R., Sun Y., Levine A., Feng Z. (2010) Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A, 107:7455-7460. (PMC2867677)
  8. Hu W., Chang C., Wu R., Zhang C., Sun Y., Tang L., Levine A. J. Feng Z. (2010) Negative Regulation of Tumor Suppressor p53 by microRNA miR-504. Molecular Cell., 38:689-699. (PMC2900922)
  9. Feng Z., Zhang C., Kang H., Sun Y., Wang H., Naqvi A., Frank A., Rosenwaks Z., Murphy M., Levine A., Hu W., (corresponding author) (2011) The regulation of female reproduction by p53 and its family members. FASEB J., 25:2245-2255. (PMC3114525)
  10. Liu J., Lin M., Zhang C., Wang D., Feng Z., Hu W. (corresponding author) (2012) TAp63g enhances nucleotide excision repair through transcriptional regulation of DNA repair genes. DNA repair, 11:167-176. (PMC3348579)
  11. Feng Z., Liu L., Zhang C., Zheng T., Wang J., Lin M., Zhao Y., Wang X, Levine A. Hu W. (corresponding author) (2012) Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A, 109:7013-7018. (PMC3345015)
  12. Zhang C., Liu J., Liang Y., Wu R., Zhao Y., Hong X., Lin M., Yu H., Liu L., Levine A., Hu W.(co-corresponding author), Feng Z. (2013) Tumor-Associated Mutant p53 Drives the Warburg Effect. Nature Communications, 4:2935 doi: 10.1038/ncomms3935. (PMC3969270)
  13. Zheng T., Wang J., Zhao Y., Zhang C., Lin M., Wang X., Yu H., Liu L., Feng Z., Hu W. (corresponding author) (2013) Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nature Communications, 4:2996 doi: 10.1038/ncomms3996.(PMC3960723)
  14. Zhao Y., Yu H., Hu W. (corresponding author) (2014) The regulation of MDM2 oncogene and its impact on human cancers. Acta Biochimica et Biophysica Sinica, 46:180-189. (PMC3932834)
  15. Li X., Yang Q., Yu H., Wu L., Zhao Y., Zhang C., Yue X., Liu Z., Wu H., Haffty B., Feng Z., Hu W. (corresponding author) (2014) LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. Oncotarget, 5:788-801. (PMC3996668)