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Zhiyuan Shen, M.D., Ph.D.

Professor and Chief

Division of Radiation Cancer Biology

Tel: 732-235-6101

Shen Lab



    • M.D., Norman Bethune University of Medical Sciences, Jilin, China .
    • MS, Institute of Radiation Medicine, Beijing, China
    • Ph.D., Colorado State University, Fort Collins, CO, USA

Academic Appointments:

    • Professor of Radiation Oncology
    • Professor of Pharmacology

Teaching Interests:

    • Dr. Shen is currently the coordinator for the radiation biology course of the radiation oncologist residency program
    • Dr. Shen is a faculty member of the Program of Cellular and Molecular Pharmacology of the Graduate Programs in Molecular Biosciences

Research Interests:

Genomic instability is a major driving force for tumorigenesis. Mammalian cells use several mechanisms to maintain their genomic stability, including high fidelity DNA replication in S-phase, accurate chromosome segregation in M-phase, error-free repair of DNA damage throughout the cell cycle, and coordinated cell cycle progression.  Our longstanding interests are the mechanisms by which genomic instability is induced and how genomic instability drives tumorigenesis. We focus on the roles of mammalian homologous recombination and its associated pathways in error-free DNA repair, replication fidelity, and precise mitotic cell division. Using a BRCA2 interacting protein BCCIP as the platform, we recently began to understand how DNA replication and recombination dysfunctions during S-phase contribute to mitotic chromosome instability.  At the same time, we develop genetically engineered mouse models to understand the confounding roles of genes with concurrent genome-maintenance and growth-essential functions at distinct stages of tumor initiation and progression.

Selected Peer-Reviewed Publications for the Recent 3 Years and earlier years: