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Human Physiology in Medicine, MSBS 5081S

Course Director: Dr. Joseph Fondell   

Dept. of Pharmacology

fondeljd@rwjms.rutgers.edu

 

 

 

Course Times: Monday and Wednesday (3:30 pm to 5:00 pm)

Room: V10 RWJMS Research Tower

 

Course Description:

This is a lecture/ discussion course covering the molecular basis of human physiological systems and related methodologies used in modern physiological and medical research. The course is subdivided into six parts including: 1) Nerve, Muscle and Bone Physiology, 2) Hormones, Signal Transduction, and Regulation of Gene Expression, 3) Sensory Physiology (hearing, taste, vision, smell, pain), 4)Pathophysiology of Metabolic Diseases, 5) Cellular and Physiological Homeostasis, and 6) Regenerative Medicine. Given the interdisciplinary nature of the course, no single textbook will be used. Rather, clinically relevant research papers, review articles or specific book chapters (assigned by each lecturer) will be available for downloading at the RWJMS AMP website or via the Rutgers RWJMS Library website.

 

Course Sections and Topics:

 

I. Nerve, Muscle and Bone Physiology

  • Membrane potentials/action potentials
  • Neurons and synaptic transmission
  • Ca2+ signaling and muscle contraction
  • Minerals and bone

 

II. Hormones, Signal Transduction and Gene Expression

  • mTOR signaling
  • Growth factors
  • Opioid signaling
  • Nuclear Hormone Receptors

 

III. Sensory Physiology

  • TRP channels as cellular sensors
  • Taste
  • Audition/Hearing
  • Vision

 

IV. Cellular and Physiological Homeostasis

  • Lysosomal storage diseases
  • DNA repair/cell survival
  • Autophagy
  • Microbiome

 

V. Pathophysiology of Metabolic Diseases

  • Pathophysiology of Acid-Base disorders
  • Diabetes Mellitus
  • Diabetes Mellitus and Metabolic Syndrome
  • research paper discussion

 

VI. Regenerative Medicine

  • Immunotherapy and cancer
  • Neuronal stem cells
  • Stem cell regenerative medicine for disease
  • Tissue engineering using biosynthetic materials