DiCicco-Bloom, Emanuel M.D.
MD, Cornell University Medical College, 1977
Phone: (732) 235-5381 Fax: (732) 235-4990
Research Interests: Gene and growth factor regulation of neurogenesis during mammalian brain development, with a focus on models of human neurodevelopmental disorders, including autism, schizophrenia and environmental teratogens. One direction of research explores the roles of extracellular growth factors, such as IGF1, bFGF and PACAP, in regulating proliferation of neural precursors in cerebral cortex, hippocampus and cerebellum, working via cell cycle machinery, especially cyclin-dependent kinase inhibitors. Another area of interest examines the effects of environmental teratogens, including methylmercury and neurotherapeutic valproic acid, on neural stem cell proliferation in prenatal cortex and postnatal hippocampus, defining effects on proliferation and programmed cell death, as well as neurogenesis and behavioral consequences. Finally, we are defining the roles of the autism-associated gene, Engrailed 2, in development of cerebellum and hindbrain, as well as secondary effects on forebrain structure and functions. These studies are performed in neural stem cell cultures, and in embryonic and postnatal rodent brains, altering growth factors, genes and microRNAs by using knock out technology, gene over/under expression methods (transfection, in utero electroporation) and pharmacological approaches with subsequent analyses of mRNAs, proteins, cell and tissue morphology and animal behaviors.
National Advisory Positions: Dr. DiCicco-Bloom serves on several autism and brain disease related scientific panels including Autism Speaks, the Autism Science Foundation, the Autism Tissue Program, the International Rett Syndrome Foundation, the NIH Developmental Brain Disorders study section, the Rutgers University Brain Health Institute (Autism), and the Society for Neuroscience Government & Public Affairs committee, as well as several neuroscience journal editorial boards.
For complete list PubMed
- Nicot, A., Lelièvre, V., Tam, J., Waschek, J.A. and DiCicco-Bloom, E. (2002) Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Sonic Hedgehog (Shh) Interact to Control Cerebellar Granule Precursor Cell Proliferation. J Neurosci 22:9244-54.
- Benayed, R., Gharani, N., Rossman, I., Mancuso, V., Lazar, G., Kamdar, S., Bruse, SE., Tischfield, S., Smith, BJ., Zimmerman, RA., DiCicco-Bloom, E., Brzustowicz, LM., and Millonig, JH. (2005) Support for the homeobox transcription factor, ENGRAILED 2, as an Autism Spectrum Disorder (ASD) susceptibility locus. Am J Hum Genet 77:851-68. Epub 2005 Oct 5.
- DiCicco-Bloom, E. (2006) Perspectives NEUROSCIENCE: Neuron, Know Thy Neighbor. Science 311:1560-1562. 10.1126/science.1126397
- DiCicco-Bloom, E., Lord, C., Zwaigenbaum, L., Courchesne, E., Dager, SR., Schmitz, C., Schultz, RT., Crawley, J., and Young, LJ. (2006) The Developmental Neurobiology of Autism Spectrum Disorder. Mini-Review. J Neurosci. 26:6897-6906.
- DiCicco-Bloom E., It’s a Question of Development: Autism from Bench to Clinic, Neuron (2007), doi:10.1016/j.neuron.2007.03.023
- Falluel-Morel, A., Sokolowski, K., Sisti, H.M., Zhou, X., Shors, T.J., DiCicco-Bloom, E. (2007) Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis, and severe learning deficits during puberty. J Neurochem. 2007 Dec; 103(5):1968-81. Epub Aug 30.
- Falluel-Morel, A., Tascau, L.I., Sokolowski, K., Brabet, P., DiCicco-Bloom, E. (2008) Granule cell survival is deficient in PAC1-/- Mutant cerebellum. J Mol Neurosci. 36(1-3):38-44. 2008 Epub Apr 12.
- Ye, W., Mairet-Coello, G., Pasoreck, E., DiCicco-Bloom, E. (2008) Patterns of p57Kip2 expression in embryonic rat brain suggest roles in progenitor cell cycle exit and neuronal differentiation. Dev Neurobiol. 2009 Jan; 69(1):1-21, Epub 2008 Sep 23.
- Mairet-Coello, G., Tury, A., DiCicco-Bloom, E. (2009) IGF-1 promotes G1/S cell cycle progression through bidirectional regulation of cyclins and CDK inhibitors via the PI3K/Akt pathway in developing rat cerebral cortex. J Neurosci. 2009 Jan 21; 29(3):775-88.
- Tury, A., Mairet-Coello, G., DiCicco-Bloom, E. (2011) The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursors. Cereb Cortex. 2011 Aug;21(8):1840-56. Epub 2011 Jan 18.
- Sokolowski, K., Falluel-Morel, A., Zhou, X., DiCicco-Bloom, E. (2011) Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures. Neurotoxicology. 2011 Oct;32(5):535-44. Epub 2011 Jun 29.
- Tury, A., Mairet-Coello, G., DiCicco-Bloom, E. (2011) The multiple roles of the cyclin-dependent kinase inhibitory protein p57(KIP2) in cerebral cortical neurogenesis. Dev Neurobiol. 2011 Nov 10. doi: 10.1002/dneu.20999. [Epub ahead of print]
- Mairet-Coello, G., Tury, A., Van Buskirk, E., Robinson, K., Genestine, M., DiCicco-Bloom, E. (2012) p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex. Development; 139(3):475-87.
- DiCicco-Bloom, E., Falluel-Morel, A. (2009) Neural Development and Neurogenesis. In: Kaplan & Sadock's Comprehensive Textbook of Psychiatry, Ninth Edition, Ed. B.J. Sadock, V.A. Sadock, P. Ruiz, Wolters Kluwer Lippincott Williams & Wilkins, Philadelphia, pages 42-64.
- Rossman, I.T. and DiCicco-Bloom, E. (2008) Chapter 1. ENGRAILED 2 and Cerebellar Development in the Pathogenesis of Autism Spectrum Disorders. In: Autism: Current Theories and Evidence. Ed. A. W. Zimmerman, Humana Press, a part of Springer Scientific Business Media, LLC, Totowa, NJ, page 3-40.
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