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recruited in two areas. One of the goals
is to expand research in inflammation
and immunity, which include illnesses
such as asthma, type 1 diabetes,
pediatric lupus, and juvenile arthritis.
The institute also will recruit scientists
to expand its studies of neurodevelopmental disor-
ders, including childhood autism.
The Child Health Institute will utilize the grant to
strengthen its translational research program, which
employs findings from laboratory investigations
into the development of treatment and prevention
methods, improving the care provided to children.
Another initiative being planned is a pilot grant
program supporting novel investigations with the
potential to become significant research projects.
D
ean's
D
esk
From the
The
Child Health Institute of New
Jersey
has been awarded a $5 million grant
from the Robert Wood Johnson Foundation.
The funding, secured with the help of Rutgers
University Foundation, will expand and enhance
the core mission of the Child Health
Institute, and allow for continued
growth of the basic science mis-
sion, along with the opportunity to
expand research endeavors by
recruiting accomplished scientists
who focus on the development of
therapeutic tools and the preven-
tion of pediatric disorders.
Arnold Rabson, MD
, the
Laura Gallagher Chair of Devel-
opmental Biology and director of the institute,
indicated that new investigators will likely be
Child Health
$5M Grant
Research
National Institute of Child Health
and Human Development.
In pre-term infants who show
signs of jaundice, it is standard
practice to test for total serum
bilirubin, one of two types of biliru-
bin, in order to plan a course for
treatment. According to the re-
searchers, however, measuring
solely for the level of the second
type, unbound bilirubin would
more accurately determine the risk
of neurotoxicity, as unbound biliru-
bin is capable of crossing the blood
brain barrier and inducing brain
toxicity.
In addition, the researchers
found that the ability to metab-
olize the free fatty acids and the
resulting amount of unbound
bilirubin is highly variable
among premature newborns.
The standard test for total
serum bilirubin, therefore,
cannot be utilized to predict
the unbound bilirubin level
and potential for neurological
impairment.
Study Indicates Better Test for Jaundice
Arnold Rabson, MD
John Emerson
Roy Groething
A
new study published in The Journal of
Pediatrics
by researchers in the Department
of Pediatrics indicates that there is a more
accurate test for jaundice, a common disorder in
newborns. Jaundice in preterm infants is caused
by the elevation of bilirubin, an orange-yellow
substance in the blood that is not properly
processed by the infant's immature liver.
The problem also occurs in full-term infants.
If not treated effectively, excess bilirubin can
cause severe neurological damage and death.
The study was led by
Thomas Hegyi, MD
,
professor of pediatrics and principal investiga-
tor, and funded by the Eunice Kennedy Shriver
Thomas Hegyi, MD
John Emerson