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Hua Zhong, M.D.


Present Title:
Assistant Professor
Department of Pathology and Laboratory Medicine
08/2012 to Present

Office Address:
UMDNJ-Robert Wood Johnson Medical School
One Robert Wood Johnson Place - MEB 212
New Brunswick, NJ 08901

Clinical Expertise:
Surgical Pathology

Research Expertise:
Tissue hypoxia
Cancer biology, diagnostic and prognostic markers
Genitourinary malignancies

Undergraduate Education:
Medical College of Nanchang University
Nanchang, China
M.B.
09/1979 - 07/1984

Graduate Education:
Peking University Health Science Center
Beijing, China
Ph.D.
09/1991 - 06/1996

Postgraduate Training:
Roswell Park Cancer Institute
Buffalo, New York
Oncological Surgical Pathology
07/2011 – 06/2012

New York University School of Medicine
New York, New York
Anatomic and Clinical Pathology
07/2007 – 06/2011

The Johns Hopkins University School of Medicine
Baltimore, MD
Urological Oncology, Research Fellow
11/1996 – 06/2000

Academic Appointments:
Assistant Professor of Pathology
UMDNJ-Robert Wood Johnson Medical School/The Cancer Institute of New Jersey
New Brunswick, NJ
8/2012 to Present

Clinical Instructor
Department of Pathology and Anatomical Sciences
University at Buffalo - School of Medicine
Buffalo, New York
07/2011 – 06/2012

Research Associate
Oncology - Institute for Cell Engineering
Johns Hopkins Medical School
Baltimore, MD
08/2006 – 05/2007

Assistant Professor, Research Track
Hematology/Oncology - Winship Cancer Institute
Emory University School of Medicine
Atlanta, GA
07/2004 – 07/2006

Instructor
Hematology/Oncology - Winship Cancer Institute
Emory University School of Medicine
Atlanta, GA
07/2001 – 06/2004

Associate
Hematology/Oncology - Winship Cancer Institute
Emory University School of Medicine, Atlanta, GA
06/2000 – 06/2001

Hospital Appointments:
Robert Wood Johnson University Hosptial (RWJUH)
One Robert Wood Johnson Place
New Brunswick, NJ 08903
Pending

Licensure:
State of New Jersey
State of New York

Certification:
2011- American Board of Pathology (Anatomic and Clinical Pathology)

Professional Organizations:
The United States and Canadian Academy of Pathology
College of American Pathologists
American Society for Clinical Pathology

Selected Publication

Original Articles in Journals

  • Zhong H, Agani F, Baccala AA, Laughner E, Rioseco-Camacho N, Isaacs WB, Simons JW, and Semenza GL; Increased expression of hypoxia inducible factor- 1alpha in rat and human prostate cancer. Cancer Res., 58(23):5280-4, 1998.
  • Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, and Simons JW; Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their
    metastases. Cancer Res., 59(22): 5830-5, 1999.
  • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, and Semeza GL;
    Modulation of hypoxia-inducible factor 1alpha expression by the EGF/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res., 60(6):1541-5, 2000.
  • Zagzag D, Zhong H, Scalzitti J, Laughner E, Simons J, and Smeza G; Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer, 88(11):2606-18, 2000.
  • Bos R, Zhong H, Hanrahan C, Mommers E, Semenza G, Pinedo H, Abeloff M, Simons J, van Diest P, and
    van Der Wall E; Levels of hypoxia-inducible factor-1alpha during breast carcinogenesis. J Natl Cancer Inst., 93(4):309-14, 2001.
  • Mabjeesh N, Post D, Willard M, Kaur B, Van Meir E, Simons J, and Zhong H; Geldanamycin induces
    degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res., 62(9):2478-82, 2002.
  • Govindarajan B, Bai X, Choen C, Zhong H, Kilroy S, Moses M, and Arbiser JL; Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling. J Biol Chem., 278(11):9790-5, 2003.
  • Mabjeesh N, Willard M, Zhong H, and Simons J; Androgens stimulate hypoxia inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3’-kinase/protein kinase B in prostate cancer cells. Clin Cancer Res., 9(7):2416-25, 2003.
  • Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons
    JW, and Giannakakou P; 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and
    dysregulating HIF. Cancer Cell, 3(4):363-75, 2003.
  • Zhong H, Willard M, and Simons J; NS398 Reduces Hypoxia-inducible Factor (HIF)-1alpha and HIF-1 Activity: multiple-level effects involving COX-2- dependent and independent mechanisms; International Journal of Cancer, 112(4):585-95, 2004.
  • Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, and Semenza GL; Complete loss of ischemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1alpha.
    Cardiovasc Res., 77(3): 463-70, 2008.

Abstracts:

  • Zhong H, Simons JW and Zagzag D; Chronic intermittent hypoxia regulates HIF-1α in cancer cells and
    leads to an aggressive phenotype; USCAP 97th Annual Meeting, March 1-7, 2008, Denver, Colorado.
  • Zhong H, Fox-Talbot K, Zagzag D and Semenza G; Adenosine but not diazoxide or ischemic
    preconditioning significantly reduces myocardial injury in HIF-1alpha deficient heart; USCAP 98th Annual Meeting, March 7-13, 2009, Boston, Massachusetts.
  • Zhong H, Wang R, Willard M, Nie D, Kelavkar U, Ohh M and Simons JW; 15-Lipoxygenase-1 promotes
    hypoxia-inducible factor 1α degradation dependent of intact enzymatic activity; USCAP 99th Annual Meeting, March 20-26, 2010, Washington, D.C.
  • Zhong H, Wang R and Simons JW; Elevated interstitial pressure enhances hypoxia-induced vascular
    endothelial growth factor expression (VEGF) via hypoxia-inducible factor-1 (HIF-1) in Daoy medulloblastoma cells; USCAP 100th Annual Meeting, March 26-April 4, 2011, San Antonio, Texas.
  • Zhong H, Azabdaftari G, and Xu B; Histopathological and Clinical Characterization of Intradiverticular
    Carcinoma in Urinary Bladder; USCAP 101st Annual Meeting, March 17-23, 2012. Vancouver, BC, Canada.
  • Zhong H, Omilian A, Morrison C and Xu B; Activation of C-Jun N-Terminal Kinase is Associated with
    Histological Grade of Mucoepidermoid Carcinoma; USCAP 101st Annual Meeting, March 17-23, 2012.
    Vancouver, BC, Canada.