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Community Outreach

Selected Publications:

Kim, K.-E., Gu, C., Thakur, S., Vieira, E., Lin, J.C., and Rabson, A.B.  Transcriptional regulatory effects of lymphoma-associated NFKB2/lyt10 protooncogenes. Oncogene, 2000, 19: 1334-1345.

Suh, J.S., Payvandi, F., Edelstein, L.C., Amenta, P.S., Zong, W.-X., Gélinas, C., and Rabson, A.B.  Mechanisms of constitutive NF-kB activation in human prostate cancer cells. The Prostate, 52:183-200, 2002.

 

Nelson, D.A., Tan, T.-T., Rabson, A.B., Anderson, D, Degenhardt, K., and White, E. Hypoxia and defective apoptosis drive genomic instability and tumorigenesis. Genes and Development, 18:2095-2107, 2004.

 

Lin, H.-C., Hickey, M., Hsu, L., Medina, D., and Rabson, A.B. Activation of Human T-Cell Leukemia Virus Type 1 LTR and Cellular Promoters by T-Cell Receptor Signaling and HTLV-1 Tax Expression. Virology, 339:1-11, 2005.

 

Zhao, Y., Ramakrishnan, A., Kim, K.-E., and Rabson, A.B. Regulation of Bcl-3 through interaction with the Lck tyrosine kinase Biochemical and Biophysical Research Communications, 335:865-873, 2005.

 

Hansson, A., Marin Y.E., Suh, J., Rabson, A.B., Chen, S., Huberman, E., Chang, R.L., Conney, A.H., Zheng, X., Enhancement of TPA-induced growth inhibition and apoptosis in myeloid leukemia cells by BAY11-7082, am NF-kappaB inhibitor. Int. J Oncol. 27L9410948, 2005.

 

Medina, D.J., Sheay, W., Osman, M., Goodell, L., Rabson, A.B., and Strair, R.K.  Adenovirus infection and cytotoxicity of primary mantle cell lymphoma cells. Experimental Hematology, 33:1337-1347, 2005.

 

Strair, R.K., Gharibo, M., Schaar, , D., Rubin, A., Harrison, J., Aisner, J., Lin, H.-C., Lin, Y., Goodell, L., Anand, M., Balsara, B., Dudek, L., Rabson,  A., and Medina, D.J.  Nuclear Factor-kappaB (NF-kB) modulation by choline magnesium trisalicylate +/- dexamethasone in patients undergoing induction chemotherapy for acute myelogenous leukemia. Clinical Cancer Res. 14: 7564-7568, 2008.

 

The Xiang laboratory is focused on understanding the molecular mechanisms that govern the determination and differentiation of highly specialized sensory cells and neurons. His lab employs molecular genetic approaches to identify and study transcription factors that are required for programming development of the retina, inner ear, sensory ganglion, and central nervous system. A major focus is to develop animal models to study roles of transcription factor genes in normal sensorineural development, as well as to elucidate how mutations in these genes cause sensorineural disorders such as blindness and deafness.

 

Selected Publications:

Li, S., Price, S. M., Cahill, H., Ryugo, D. K., Shen, M. M., and Xiang, M. (2002) Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Development 129:3523-3532.

Mo, Z., Li, S., Yang, X., and Xiang, M. (2004) Role of the Barhl2 homeobox gene in the specification of glycinergic amacrine cells. Development 131:1607-1618.

Li, S., Qiu, F., Xu, A., Price, S. M., and Xiang, M. (2004) Barhl1 regulates migration and survival of cerebellar granule cells by controlling expression of the neurotrophin-3 gene. J. Neurosci. 24:3104-3114.

Li, S., Mo, Z., Yang, X., Price, S. M., Shen, M. M., and Xiang, M. (2004) Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. Neuron 43:795-807.

Li, S., Misra, K., Matise, M., and Xiang, M. (2005) Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord. Proc. Natl. Acad. Sci. USA 102:10688-10693.

Chellappa, R., Li, S., Pauley, S., Jahan, I., Jin, K., and Xiang, M. (2008) Barhl1 regulatory sequences required for cell-specific gene expression and autoregulation in the inner ear and central nervous system. Mol. Cell. Biol. 28:1905-1914.

Qiu, F., Jiang, H., and Xiang, M. (2008) A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. J. Neurosci. 28:3392-3403.

Jiang, H. and Xiang, M. (2009) Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1. J. Neurosci. 29:10449-10459.

Dr. Bhaumik is an Assistant Professor and Manager of the Transgenic/Knock-out Mouse Shared Resource of the Cancer Institute of New Jersey and UMDNJ-Robert Wood Johnson Medical School.  His laboratory has developed a number of critical genetically-engineered mouse strains for members of the UMDNJ-RWJMS and Rutgers scientific communities, and is actively involved in developing and implementing new technologies for developing new mouse models of human diseases and studying mouse development.

 

Selected Publications:

Stillwell E, Vitale J, Zhao Q, Beck A, Schneider J, Khadim F, Elson G, Altaf A, Yehia G, Dong JH, Liu J, Mark W, Bhaumik M, Grange R, Fraidenraich D. Blastocyst injection of wild type embryonic stem cells induces global corrections in mdx mice.  PLoS One. 2009;4(3):e4759.

Sunderram J, Semmlow J, Thakker-Varia S, Bhaumik M, Hoang-Le O, Neubauer JA. Heme oxygenase-1-dependent central cardiorespiratory adaptations to chronic hypoxia in mice. Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R300-12