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Research

The division faculty, Patricia Whitley-Williams MD, Anna Petrova MD, PhD, MPH, Sunanda Gaur MD, Amisha Malhotra MD, Roseann Marone RN, BSN, MPH, and Gail Burack, PhD are actively involved in research studies conducted in the division and in partnership with colleagues at the Department of Pediatrics as well as outside of the Rutgers Robert Wood Johnson Medical School.  The division faculty supports participation of undergraduate and medical students as well as pediatric residents in research projects, presentations, and publications.

 

Research projects

 

Title:  Adherence to antiretroviral therapy (ART) in pediatric patients with human immunodeficiency virus (HIV-1).  Investigators: Gail Burack, PhD, Sunanda Gaur, MD, Roseann Marone, RN, BSN, MPH, and Anna Petrova, MD, MPH

Title: Impact of HIV-1 mutagenesis on the clinical, virological and immunological presentation of HIV disease in children. Investigators:  Amisha Malhotra, MD, Sunanda Gaur, MD, Patricia Whitley-Williams, MD, Caitlin Loomis, BA, and Anna Petrova, MD, PhD, MPH

 

Title:  The influence of family variables and psychiatric co-morbidities upon treatment adherence in children and adolescents with perinatal HIV Infection.  Investigators:  Gail Burack, Ph.D, Sunanda Gaur, MD, Roseann Marone, RN, BSN, MPH, and Anna Petrova, MD, PhD, MPH

 

Title:  Rapid HIV test utilization for women who present in labor with unknown HIV status.

Investigators:  Sunanda Gaur, M.D., Anna Petrova, M.D., PhD, MPH, Roseann Marone, RN, MPH, Amisha Malhotra, M.D., Patricia Whitley-Williams, M.D., Denise Neta, M.D., Manuel Jimenez, BA, Charlene Flash, MPH, Tanushree Dutta, BA, Sonal Shah, M.D.

 

Publications (2004 -2014)

 

2013-2014

 

Weaver M, Mauriello C, Galperina K, Gaur S, Moorthy LN, Evans M, Ratanasen M, Li ST. Index of suspicion. Case 1: Daily fevers, rash, myalgia, arthralgia, and hepatomegaly in a teen-age girl. Case 2: Subcutaneous nodules and arthritis in an 11-year-old boy. Case 3: Fever, fatigue, cervical lymphadenopathy, and hepatosplenomegaly in a 3-year-old boy. Pediatr Rev. 2013;34:137-42

 

Kurtyka K, Gaur S, Mehrotra N, Chandwani S, Janevic T, Demissie K. Adverse Outcomes Among Asian Indian Singleton Births in New Jersey, 2008-2011. J Immigr Minor Health. 2014 [Epub ahead of print]

 

Krishnarajah G, Demissie K, Lefebvre P, Gaur S, Sheng Duh M. Clinical and cost burden of rotavirus infection before and after introduction of rotavirus vaccines among commercially and Medicaid insured children in the United States. Hum Vaccin Immunother. 2014;10(8). [Epub ahead of print]

 

Malhotra A, Whitley-Williams PN, Gaur S, Petrova A. Treatment Response in Association with Adherence Patterns to Highly Active Antiretroviral Therapy in Pediatric Patients with Perinatally Acquired HIV Infection. J Int Assoc Provid AIDS Care. 2014;13:461-5

 

Fierer DS, Dieterich DT, Mullen MP, Branch AD, Uriel AJ, Carriero DC, van Seggelen WO, Hijdra RM, Cassagnol DG; New York Acute Hepatitis C Surveillance Network (collaborator Malhotra A). Telaprevir in the treatment of acute hepatitis C virus infection in HIV-infected men. Clin Infect Dis. 2014;58:873-9

Bal AK, Prasad D, Umali Pamintuan MA, Mammen-Prasad E, Petrova A. Timing of Intravenous Immunoglobulin Treatment and Risk of Coronary Artery Abnormalities in Children with Kawasaki Disease. Pediatr Neonatol. 2014;10: S1875-9572

Mehta R, Petrova A.Is variation in total antioxidant capacity of human milk associated with levels of bio-active proteins? J Perinatol 2014;34:220-22

Pinto JM, Chu D, Petrova A. Pediatric residents' perceptions of family-centered rounds as part of postgraduate training. Clin Pediatr (Phila). 2014;53:66-70

St Fleur R, Petrova A. Knowledge and Perception of Breastfeeding Practices in Hispanic Mothers in Association with Their Preferred Language for Communication. Breastfeed Med. 2014 May 2. [Epub ahead of print]

Pinto JM, Schairer JL, Petrova A. Comparative effectiveness of implementation of a nursing-driven protocol in reducing bronchodilator utilization for hospitalized children with bronchiolitis. J Eval Clin Pract. 2014;20:267-72

Marshall I, Mehta R, Petrova A. Vitamin D in the maternal-fetal-neonatal interface: clinical implications and requirements for supplementation. J Matern Fetal Neonatal Med 2013;26:633-38

 

2011-2012

 

National Center for Immunization and Respiratory Diseases (Whitley-Williams P, collaborator) General recommendations on immunization --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011; 28;60(2):1-64

 

Malee K, Williams P, Montepiedra G, McCabe M, Nichols S, Sirois PA, Storm D, Farley J, Kammerer B; PACTG 219C Team. Medication adherence in children and adolescents with HIV infection: associations with behavioral impairment. AIDS Patient Care STDS. 2011;25:191-200

 

Patel C, Chaudhuri NR, Gaur S.Group A streptococcus ventriculoperitoneal shunt infection in a child. Pediatr Infect Dis J. 2012;31:660.

 

Shakkottai A, Bupathi K, Patel AP, Chalom E, Chamarthi S, Lehman TJ, Peterson MG, Gaur S, Moorthy LN. Children with partial IgA deficiency: clinical characteristics observed in the pediatric rheumatology clinic. Clin Pediatr (Phila). 2012;51:46-50

 

Mehrotra N, Gaur S, Petrova A.Health care practices of the foreign born Asian Indians in the United States. A community based survey. J Community Health. 2012;37:328-34

 

Bhatt M, Petrova A, Mehta R. Does treatment of patent ductus arteriosus with cyclooxygenase inhibitors affect neonatal regional tissue oxygenation?  Pediatr Cardiol. 2012;33:1307-14.

Petrova A, Mehta R. Magnesium sulfate tocolysis and intraventricular hemorrhage in very preterm infants. Indian J Pediatr 2012;79:43-47

Petrova A, Bhatt M, Mehta R.Regional tissue oxygenation in preterm born infants in association with echocardiographically significant patent ductus arteriosus. J Perinatol. 2011;31:460-64.

 

Mehta R, Petrova A. Very preterm gestation and breastmilk cytokine content during the first month of lactation. Breastfeeding Medicine 2011;6:21-24

Mehta R, Petrova A. Biologically active breast milk proteins in association with very preterm delivery and stage of lactation. J Perinatol 2011;31:58-62

 

2009-2010

 

Moorthy LN, Gaur S, Peterson MG, Landa YF, Tandon M, Lehman TJ. Poststreptococcal reactive arthritis in children: a retrospective study. Clin Pediatr (Phila). 2009;48:174-82

 

Petrova A, Ayers C, Stechna S, Gerling JA, Mehta R. Effectiveness of exclusive breastfeeding promotion in low-income mothers: a randomized controlled study.Breastfeed Med. 2009;4:63-69

 

Williams PL, Marino M, Malee K, Brogly S, Hughes MD, Mofenson LM; PACTG 219C Team (collaborators Gaur S, Whitley-Williams P, Malhotra A). Neurodevelopment and in utero antiretroviral exposure of HIV-exposed uninfected infants. Pediatrics. 2010;125:e250-60

 

Kapetanovic S, Aaron L, Montepiedra G, Sirois PA, Oleske JM, Malee K, Pearson DA, Nichols SL, Garvie PA, Farley J, Nozyce ML, Mintz M, Williams PL; Pediatric AIDS Clinical Trials (collaborators Gaur S, Whitley-Williams P, Malhotra A) The use of second-generation antipsychotics and the changes in physical growth in children and adolescents with perinatally acquired HIV. AIDS Patient Care STDS. 2009;23:939-47

Sirois PA, Montepiedra G, Kapetanovic S, Williams PL, Pearson DA, Malee K, Garvie PA, Kammerer BL, Nichols SL, Nozyce ML, Mintz M, Mitchell WG, Oleske JM; IMPAACT/PACTG 219C Team (collaborators Gaur S, Whitley-Williams P, Malhotra A). Impact of medications prescribed for treatment of attention-deficit hyperactivity disorder on physical growth in children and adolescents with HIV. J Dev Behav Pediatr. 2009;30:403-12

 

National Center for Immunization and Respiratory Diseases, CDC; Centers for Disease Control and Prevention (CDC) (collaborator Whitley-Williams P).Use of influenza A (H1N1) 2009 monovalent vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009. MMWR Recomm Rep. 2009; 28;58(RR-10):1-8

 

Patel K, Ming X, Williams PL, Robertson KR, Oleske JM, Seage GR 3rd; International Maternal Pediatric Adolescent AIDS Clinical Trials 219/219C Study Team (collaborators Gaur S, Whitley-Williams P, Malhotra A). Impact of HAART and CNS-penetrating antiretroviral regimens on HIV encephalopathy among perinatally infected children and adolescents. AIDS. 2009; 10;23:1893-901

 

Malee K, Williams PL, Montepiedra G, Nichols S, Sirois PA, Storm D, Farley J, Kammerer B; PACTG 219C Team (collaborators Gaur S, Whitley-Williams P, Malhotra A). The role of cognitive functioning in medication adherence of children and adolescents with HIV infection. J Pediatr Psychol. 2009;34:164-75

 

Burack G, Gaur S, Marone R, Petrova A. Adherence to antiretroviral therapy in pediatric patients with human immunodeficiency virus (HIV-1). J Pediatr Nurs. 2010;25:500-4

 

Kohli V, Gaur S, Deen M, Engel M, Shah K. Orbital cysticercosis presenting as recurrent periorbital cellulitis in a four-year-old child. Pediatr Infect Dis J. 2010;29:481

 

 Gaur S, Whitley-Williams P, Flash C, Jimenez E, Petrova A. Disparity in hospital utilization of rapid HIV-1 testing for women in labor with undocumented HIV status. Matern Child Health J. 2010;14:268-73

 

Birchwood G, Mehta R, Petrova A.. Normal distribution of pre-discharge total serum bilirubin in a culturally diverse cohort of healthy term newborn infants. Journal of Neonatal-Perinatal Medicine 2010;3:223-227

 

Petrova A, Mehta R. Regional tissue oxygenation in association with duration of hypoxaemia and haemodynamic variability in preterm neonates. Arch Dis Child Fetal Neonatal Ed. 2010;95:F213-19.

 

2007-2008

 

Malhotra A, Gaur S, Whitley-Williams P, Loomis C, Petrova A.Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus-1 (HIV-1) infected pediatric patients: a cross-sectional study. AIDS Res Ther. 2007; 9;4:15

 

Petrova A, Hegyi T, Mehta R. Maternal race/ethnicity and one-month exclusive breastfeeding in association with the in-hospital feeding modality. Breastfeeding Med 2007;2:92-8

 

Petrova A, Mehta R. Dysfunction of innate immunity and associated pathology in neonates. Indian J Pediatr 2007;74:185-91

 

Bonifacio L, Petrova A, Nanjundaswamy S, Mehta R. Thrombocytopenia related neonatal outcome in preterms. Indian J Pediatr 2007;74:269-74

 

Murphy TV, Slade BA, Broder KR, Kretsinger K, Tiwari T, Joyce PM, Iskander JK, Brown K, Moran JS; Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC) (collaborator Whitley-Williams P). Prevention of pertussis, tetanus, and diphtheria among pregnant and postpartum women and their infants recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008;57(RR-4):1-51

 

Patel K, Hernán MA, Williams PL, Seeger JD, McIntosh K, Dyke RB, Seage GR 3rd; Pediatric AIDS Clinical Trials Group 219/219C Study Team (collaborators Gaur S, Whitley-Williams P, Malhotra A).Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting. Clin Infect Dis. 2008;46:1751-60

 

Tassiopoulos K, Williams PL, Seage GR 3rd, Crain M, Oleske J, Farley J; International Maternal Pediatric Adolescent AIDS Clinical Trials 219C Team (collaborators Gaur S, Whitley-Williams P, Malhotra A). Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children.J Acquir Immune Defic Syndr. 2008;47:607-14

Gaur S. Use of anti-retrovirals in pediatric HIV infection. Indian J Dermatol Venereol Leprol. 2008;74:208-14

 

Harpaz R, Ortega-Sanchez IR, Seward JF; Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC) (collaborator Whitley-Williams P).

Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008;57(RR-5):1-30

 

Van Dyke RB, Wang L, Williams PL; Pediatric AIDS Clinical Trials Group 219C Team (collaborators Gaur S, Whitley-Williams P, Malhotra A).Toxicities associated with dual nucleoside reverse-transcriptase inhibitor regimens in HIV-infected children. J Infect Dis. 2008; 1;198:1599-608

 

2004-2006

 

Gaur S, Malhotra A, Whitley-Williams P. Rates of Neisseria meningitidis increasing in young adults. Pediatr Ann. 2004;33:590-5

 

Nanjundaswamy S, Mehta R, Petrova A., Hegyi T. The accuracy of transcutaneous bilirubin measurements in neonates: A correlation study. Biology of Neonates 2004;85;21-25

 

Petrova A, Hanna N, Mehta R. Gestational age related maternal-fetal-neonatal humoral immunity. The Journal of Applied Research 2004;4:44-49

 

Hanna N, Ahmed K, Anwar M, Petrova A, Hiatt M, Hegyi T. Effect of storage on breast milk antioxidant activity. Archives of Disease in Childhood Fetal and Neonatal Edition 2004;89:F518-F520.

 

Mehta R, Petrova A. Neutrophil function in neonates born to gestational diabetic mothers. Journal of Perinatology 2005;25:178-81

 

Nanjundaswamy S, Petrova A, Mehta R, Hegyi T. Transcutaneous bilirubinometry in preterm neonates under phototherapy. American Journal of Perinatology 2005;22:127-131

 

Petrova A, Mehta R. Innate Immunity in Mothers and Their Newborn Infants during Preterm Premature Rupture of Membranes. Journal of Applied Research 2005; 5:282-288.

 

Ojadi V, Petrova A, Mehta R, Hegyi T. Risk of cardio-respiratory abnormalities in preterm infants placed in car seats: a cross-sectional study. BMC Pediatrics 2005, 5:28

 

Ginocchio CC, Zhang F, Malhotra A, Manji R, Sillekens P, Foolen H, Overdyk M, Peeters M.

Development, technical performance, and clinical evaluation of a NucliSens basic kit application for detection of enterovirus RNA in cerebrospinal fluid. J Clin Microbiol. 2005;43:2616-23.

 

Mehta R, Nanjundaswamy S, Schen-Schwarz S, Petrova A: Preterm Neonatal Morbidity in Association with Placental Histology and Gestational Age. Indian Journal of Pediatrics 2006;73:25-29

 

Mehta R, Petrova A. Intrapartum magnesium sulfate exposure attenuates neutrophil function in preterm neonates. Biology of the Neonate 2006;89:99-103

 

Mehta R, Petrova A. Intrauterine neutrophil activation is associated with pulmonary hemorrhage in preterm infants. Arch Dis Child Fetal Neonatal Ed 2006;91:F415-418

 

Petrova A, Mehta R, Birchwood G, Ostfeld B, Hegyi T. Management of neonatal hyperbilirubinemia: pediatricians' practices and educational needs. BMC Pediatrics 2006; 6;6.

 

Petrova A, Mehta R. Near-infrared spectroscopy (NIRS) in the detection of regional tissue oxygenation during hypoxic events in preterm infants undergoing critical care. Pediatric Critical Care Medicine 2006;7:449-54

 

Presentations:

 

Title:  The Influence of Family Variables and Psychiatric Co-Morbidities Upon Treatment Adherence in Children and Adolescents with Perinatal HIV Infection.  Presented at the Reducing Perinatal HIV Transmission Conference, March 23, 2007.  View poster
Title:  Rapid HIV test utilization for women who present in labor with unknown HIV serostatus:  The impact of the implementation of a hospital policy.  Perinatal Collaborative Project poster presented at the AIDS International Society Conference, Brazil, July 2005 and at the 2nd International Conference on HIV Treatment Adherence in Jersey City, New Jersey, March 28-30, 2007.  View poster
Title:  Rapid HIV test utilization for women who present in labor with unknown HIV serostatus:  The impact of the implementation of a hospital policy.  Perinatal Collaborative Project poster presented at the AIDS International Society Conference, Brazil, July 2005 and at the 2nd International Conference on HIV Treatment Adherence in Jersey City, New Jersey, March 28-30, 2007.  View poster

Title:  Obstetrician and Gynecologist HIV Testing Practices.  Presented by Charlene Flash, MPH at the UMDNJ School of Public Health Research Day, Piscataway, NJ on April 11, 2006  View poster
Objective:  This study seeks to identify the proportion of obstetricians that universally offer HIV counseling and testing services to pregnant women and the factors that influence their decision whether or not to test their patients.  This study further seeks to assess obstetricianÿs knowledge, beliefs, and practices with regard to HIV testing.
Investigators:  Sunanda Gaur, M.D., Anna Petrova, M.D., PhD, MPH, Roseann Marone, RN, MPH, Amisha Malhotra, M.D., Patricia Whitley-Williams, M.D., Denise Neta, M.D., Manuel Jimenez, BA, Charlene Flash, MPH, Tanushree Dutta, BA, Sonal Shah, M.D.

  • Title:  The Relationship of Streptococcal Antibody Titers To Clinical Manifestations of Children with Post-streptococcal Reactive Arthritis View poster
    Objective:  Examine the relationship between streptococcal serology and clinical features in children with PSRA over time.
    Investigators:  L. Nandini Moorthy, Yanetsi Flores, Margaret G. E. Peterson, Karen B. Onel, Sunanda Gaur, Maria Baratelli, Charmi Patel, Gail Charetta, T. Lehman