Sarah Hitchcock-DeGregori, Ph.D.

Undergraduate Education 

• Smith College - Northampton, MA - A.B. - Zoology

Graduate Education

• Wesleyan University - Middletown, CT - M.A. - Biology
• Case Western Reserve University - Cleveland, OH - Ph.D. - Biology

Postgraduate Training

• Brandeis University, Department of Biology - Waltham, MA- Fellowship
• British-American Heart Association - Fellowship
• Cambridge, England - Fellowship                              
  
  

Areas of Interest

Regulation of muscle contraction, actin dynamics and cellular movement by the actin binding protein, tropomyosin. Bioinformatics approaches including evolutionary analysis and an evolutionary-based screen in the fission yeast are used to identify residues required for conserved tropomyosin functions. The methodologies range from biochemical and biophysical to cellular in order to address the folding, actin binding sites, structure-function relationships and cellular functions of mammalian and fission yeast isoforms of this coiled coil protein. The results will give insights into mechanisms of human myopathies cause by mutations in tropomyosin genes.

Publications

For a list of publications, please click here.