Research

Vadim Ten, MD, PhD:

Dr. Ten’s lab is NIH-funded team of investigators focused on mechanisms of neonatal diseases driven by organs developmental failure due to prematurity. The team of investigators has developed two original neonatal murine models of diseases: Alveolar developmental arrest, the disease known as neonatal bronchopulmonary dysplasia and the model of Diffuse White Matter Injury which manifests with permanent cerebral hypomyelination and sensorimotor deficit. The main mechanistic concept is that arrest of pulmonary development or failure of primary cerebral myelination is caused by sublethal mitochondrial dysfunction in the cells which define organs maturation. For example, failure of oligodendrocytes to mature into their myelin producing state. In addition, Dr. Ten’s lab studies mitochondrial mechanisms of cellular death following neonatal hypoxia-ischemia brain injury. List of publications could be found here https://www.ncbi.nlm.nih.gov/myncbi/vadim.ten.1/bibliography/public/

Funding

R01NS100850 (PI, Ten V) 04/01/2017-03/31/2022: Mitochondrial complex-I as a target for metabolic resuscitation in perinatal hypoxic-ischemic brain injury.

R0 NS099109-1 (PI, Ten V), 09/01/2016 – 08/30/2022: Mitochondrial dysfunction and white matter injury.

R01 NS088197-01-06 (MPI V. Ten and R. Deckelbaum)   04/2021 – 09/2026 Omega-3 fatty acids, acute neuroprotection via mitochondria. Department of Pediatrics, RWJMS Start-up Research Fund 2021


Nancy Reichman, PhD:

Ongoing projects:

1. Low birthweight among immigrants to the United States: cohort,duration,age-at-arrival, and region of origineffects.

2. Neonatal and longer-term outcomes of late preterm infants

Future projects:

  • Effects of infant health shocks on family food insecurity
  •  Effects of postpartum depression on social interactions
  • Testing the "weathering hypothesis" using longitudinally linked birth certificate data from NJ

Rajeev Mehta, MD:

Ongoing projects:

  • Energy metabolism mediators, type of feeding and growth in preterm born infants
  • Cerebral and renal tissue oxygenation during pre-discharge car seat testing in preterm born infants

Future projects:

  • Tissue oxygenation studies - Near Infra-Red Spectroscopy

Surasak Puvabanditsin, MD:

Ongoing projects:

Inhaled Nitric Oxide For The Prevention Of Bronchopulmonary Dysplasia (BPD) In Preterm Infants Requiring Mechanical Ventilation Or Positive Pressure Support On Days 5-14 After Birth (IK-3001-BPD-301

Future projects:

Randomizes, Double Blind, Multi-Center Study to Compare the efficacy and Safety of Micafungin Versus Amphotericin B Deoxycholate for the Treatment of Neonatal Cadidiasis