![]() |
Microbiology and Immunology, MSBS 5055S Dept. of Pharmacology
All the course materials are "Property of MBS course directors and should NOT be publicly posted or distributed, unauthorized upload of an instructor's and/or student created documents could violate the University Academic Integrity Policy and subject the student to disciplinary action.
Course Syllabus
Note: this course is a subsection of the RWJMS First Year Med course "Disease and Defense"
Course Content: Immunology: cells and tissues of the immune system and their roles in health and disease. Innate and acquired immunity. Cells and organs of the immune system and their functions and interactions; antigens and their presentation; structure, function, and diversity of antibodies; complement; major histocompatibility complex [MHC] and its roles; CD surface antigens; antigen presentation, lymphocyte development and activation, phagocytes and other mechanisms of immune defense against infection; inflammation; hypersensitivity reactions; immune tolerance; immunology of blood transfusion and transplantation. Pathogenic Micro-organisms: their structure, biology, and roles in disease; prevention and control of infections. Antimicrobial agents: Structure and modes of action of anti-microbial drugs, and mechanisms by which microbes become resistant to them; phagocytic cells and their roles in antimicrobial defense. Bacteria: Classification, structure, nutrition, physiology, and growth of bacteria; virulence factors; bacterial genetics; genetic basis of virulence; antibiotics, their modes of action and the biochemistry and genetics of resistance; diagnostic bacteriology; sterilization and disinfection; properties of the major bacterial pathogens of humans, including morphology and staining properties, virulence factors and pathogenesis, reservoirs, vectors, routes of transmission; major diseases and symptoms, important antibiotic sensitivities, vaccines and preventive measures. Protozoa: Major protozoan infections of humans; their agents, geographic distribution, life cycles, reservoirs, vectors, pathogenesis, prophylactic measures, and available drug therapy. Fungi: Structure and biology of the fungal cell; diagnosis of fungal infections; staining techniques, culture, and morphology; properties of the major fungal pathogens of humans, including identification, major diseases and symptoms, important drugs. Viruses: Structure, replication, culture, and identification of viruses; diagnosis of viral infections; antiviral drugs; major pathogenic viruses of humans; their structure, replication cycle, pathogenesis, diseases and symptoms, available drugs and vaccines; unconventional virus-like infectious agents; interferons and their actions. Goals and Objectives: Demonstrate knowledge of the cells and organs of the immune system and their roles in health and disease, including: antigens and epitopes; structure and function of antibodies; Complement; tissues and organs of the immune system; roles of its important cell types and subtypes and how they are identified and quantitated; the genetic basis of immunoglobulin structure and diversity; the major histocompatibility complex and its roles; phagocytes and other mechanisms of innate immune defense against infection; mechanisms of acquired immune defense; immunodeficiency states; inflammation and hypersensitivity reactions; mechanisms of immune tolerance; immunological aspects of blood transfusion and organ transplantation; immunization and types of vaccines. Demonstrate knowledge of the major microbial pathogens of humans: Bacteria: their classification, structure, nutrition, physiology, and genetics; genetic basis of virulence; antibiotics, their modes of action and the biochemistry and genetics of resistance; methods of diagnostic bacteriology; important bacterial pathogens of humans, including their morphology and staining properties; virulence factors and pathogenesis; risk factors for infection; habitats, reservoirs, vectors, and routes of transmission; major diseases and symptoms; important antibiotic sensitivities and resistances; vaccines and preventive measures. Protozoa: important human pathogens; their geographic distribution, life cycles, reservoirs, vectors; diseases and symptoms, prophylactic measures, and available drugs. Fungi: classification and morphology of fungi; anti-fungal drugs; methods for diagnosis of fungal infections, staining techniques, culture, serology; important fungal pathogens of humans: morphology, major diseases and symptoms, risk factors for infection. Viruses: their structure, replication, culture; methods for diagnosis of viral infections; anti-viral drugs; important pathogenic viruses of humans: their structures, replication cycles, features that promote virulence; diseases and symptoms, available drugs and vaccines; prions; interferons and their actions.
|