Current Fellows

Timothy J. Stanek, Ph.D.

Human Genetics Institute of New Jersey,
Rutgers University

Nelson Laboratories, Piscataway, NJ

timothy.stanek@rutgers.edu

Education

B.S., The College of New Jersey, Ewing, NJ

Ph.D., Thomas Jefferson University, Philadelphia, PA

INSPIRE fellow, Genetics, Rutgers University, New Brunswick, NJ

Research

Research Mentor: Chris Ellison, Ph.D.
 
My research focuses on the role of R-loops in regulating chromatin architecture in Drosophila melanogaster.

Teaching

Teaching Interests: Genetics, Genomics, and Biochemistry

Publications:

Stanek, T.J., Gennaro, V.J., Tracewell, M.A., Di Marcantonio, D., Pauley, K.L., Butt, S., McNair, C., Wang, F., Kossenkov, A.V., Knudsen, K.E., Butt, T., Sykes, S.M., McMahon, S.B. (2021). The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22. EMBO J Jun 22;e102509.  doi: 10.15252/embj.2019102509

Gennaro, V.J., Stanek, T.J., Peck, A.R., Sun, Y., Wang, F., Qie, S., Knudsen, K.E., Rui, H., Butt, T., Diehl, J.A., McMahon, S.B. (2018). Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells. PNAS 75(1);272-86.

Rappaport, J.A., Entezari, A.A., Caspi, A., Caksa, S., Jhaveri, A.V., Stanek, T.J., Ertel, A., Kupper, J., Fortina, P.M., McMahon, S.B., Jaynes, J.B., Snook, A.E., Waldman, S.A. (2021). A β-catenin-TCF-sensitive locus control region mediates GUCY2C ligand loss in colorectal cancer. Cell Mol Gastroenterol Hepatol Dec 22;S2352-345X(21)00264-2.  doi: 10.1016/j.jcmgh.2021.12.014. Online ahead of print.

 McCann, J.J., Vasilevskaya I.A., Neupane, N.P., Shafi, A.A., McNair, C., Dylgjeri, E., Mandigo, A.C., Schiewer, M.J., Schrecengost, R.S., Gallagher, P., Stanek, T.J., McMahon, S.B., Berman-Booty, L.D., Ostrander, W.F. Jr, Knudsen, K.E. (2020). USP22 Functions as an Oncogenic Driver in Prostate Cancer by Regulating Cell Proliferation and DNA Repair. Cancer Res. 80(3):430-443.

 Schrecengost, R.S., Dean, J.L., Goodwin, J.F., Schiewer, M.J., Urban, M.W., Stanek, T.J., Sussman, R.T., Hicks, J.L., Birbe, R.C., Draganova-Tacheva, R.A., Visakorpi, T., Demarzo, A.M., McMahon, S.B., Knudsen, K.E. (2014). USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression. Cancer Res 74(1);272-86.

Sussman, R.T., Stanek, T.J., Esteso, P., Gearhart, J.D., Knudsen, K.E., McMahon, S.B. (2013). The epigenetic modifier Ubiquitin Specific Protease 22 (Usp22) regulates embryonic stem cell differentiation via transcriptional repression of Sex determining region Y-box (Sox2). J Biol Chem 288(33);24234-46.

Casimiro, M.C., Crosariol, M., Loro, E., Ertel, A., Yu, Y., Dampier, W., Saria, E.A., Papanikolaou, A., Stanek, T.J., Li, Z., Wang, C., Fortina, P., Addya, S., Tozeren, A., Knudsen, E.S., Arnold, A., Pestell, R.G. (2012). ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest 122(3);833-43.

Zhang, X.Y., Pfeiffer, H.K., Mellert, H.S., Stanek, T.J., Sussman, R.T., Kumari, A., Yu, D., Rigoutsos, I., Thomas-Tikhonenko, A., Seidel, H.E., Chodosh, L.A., Packham, G., Baserga, R., McMahon, S.B. (2011). Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC. Mol Cell Bio 31(24);5037-45.

Mellert, H.S., Stanek, T.J., Sykes, S.M., Rauscher, F.J. 3rd, Schultz, D.C., McMahon, S.B. (2011). Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis. J Biol Chem 11;286(6):4264-70.

Sykes, S.M., Stanek, T.J., Frank, A., Murphy, M.E., McMahon, S.B. (2009). Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J Biol Chem 24;284(30):20197-205.