Dr. Subhajyoti De completed his BS in engineering from the Indian Institute of Technology, Kharagpur, India before pursing a PhD from the University of Cambridge, UK in the laboratory of Prof. Sarah Teichmann. There he developed computational biology approaches to study genetic variations and mutational signatures associated with human genome evolution. As a Human Frontier Science Program Fellow in the group of Prof. Franziska Michor at Harvard University, Dr. De investigated cancer as a somatic evolutionary process. He was able to demonstrate that genetic and epigenetic abnormalities in cancer genomes show non-random, context-dependent patterns.
In his independent laboratory, first at Univ. Cololorado and currently at the Rutgers Cancer Institute of New Jersey, Dr. De is investigating cancer as a complex, adaptive system using genomic, computational, and systems-level approaches. He is a recipient of NIH/NCI PSOC Trans-network Young Investigator award, and Webb-Waring Scholar award. His work has been supported by the NIH, United Against Lung Cancer Foundation and Boettcher Foundation.
Areas of Interest
Dr. De and his lab is the cancer genomics and systems biology group at Rutgers CINJ. They develop new methods and work in close collaboration with bench scientists and clinicians on relevant projects. Their research includes genomic instability in cancer, regulatory alterations in cancer, evolutionary dynamics of cancer, and somatic mutations in benign human tissues.
A list of publications can be found here.