Horizon Discovery and Rutgers University Form Exclusive Partnership to Develop Next Generation Novel Gene Editing Technology
Dr. Shengkan ‘Victor’ Jin of Rutgers University stated: “The cytidine deaminase version of the technology alone could potentially be used for developing ex vivo therapeutics such as gene modified cells for sickle cell anemia and beta thalassemia, HIV resistant cells for AIDS, and over-the-shelf CAR-T cells for leukemia, as well as in vivo therapeutics for inherited genetic diseases. The potential is enormous. In addition to the ‘simple’ diseases caused by a single genetic alteration event, the therapeutic strategy, in principle, could also be useful for treating diseases where permanently targeting a disease-related gene is beneficial.”
SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation.
Chi Kwan Tsang, Miao Chen, Xin Cheng, Yanmei Qi, Yin Chen, Ishani Das, Xiaoxing Li, Brinda Vallat, Li-Wu Fu, Chao-Nan Qian, Hui-Yun Wang, Eileen White, Stephen K. Burley, X.F. Steven Zheng. 2018 Molecular Cell 70, 502-515, May 3 2018
Hyewon Kong and Navdeep S. Chandel Maintaining redox balance in cancer cells is essential for tumor development and progression. In this issue of Molecular Cell, Tsang et al. (2018) identify an evolutionarily conserved mTORC1-dependent mechanism by which cancer cells control redox homeostasis in ischemic tumor microenvironment. 2018 Molecular Cell 70, 502-515, May 3 2018
Article preview by Navdeep Chandel
Pyocyanin Inhibits Chlamydia Infection by Disabling Infectivity of the Elementary Body and Disrupting Intracellular Growth.
Li JL, Yang N, Huang L, Chen D, Zhao Y, Tang MM, Fan H, Bao X. Antimicrob Agents Chemother. 2018 Apr 2. pii: AAC.02260-17. doi: 10.1128/AAC.02260-17. [Epub ahead of print]
Effect of mitochondrial uncouplers niclosamide ethanolamine (NEN) and oxyclozanide on hepatic metastasis of colon cancer
Amer Alasadi, Michael Chen, G. V. T. Swapna, Hanlin Tao, Jingjing Guo, Juan Collantes, Noor Fadhil, Gaetano T. Montelione and Shengkan Jin. Cell Death and Disease (2018) 9:215