Fran Yu, MD, PhD

Fran Yu is Board-certified in Family Medicine and earned her Doctor of Medicine from Norman Bethune University of Medical Sciences in China. She completed her residency at Maine Dartmouth Family Practice in Augusta, ME. Before her residency training, she received additional residency training in Neurology in China and then earned her PhD in Neuroscience in Japan.

She is also a certified Physician Acupuncturist from Harvard Medical School Continuing Educational Program. Dr. Yu is able to treat patients of all ages. Dr. Yu’s experience and her multicultural background have afforded her sensitivity and respect for the diverse population of patients and families we serve in our community.

In her spare time, Dr. Yu enjoys gardening and raising hens in her backyard. 

Undergraduate School and Area of Concentration

• Norman Bethune University of Medical Sciences in China, Doctor of Medicine

Graduate School and Field of Study

• Norman Bethune University of Medical Sciences in China, Doctor of Medicine
• Kyushu University School of Medicine in Japan, PhD of Neuroscience

Residency

• Maine Dartmouth Family Practice, Family Medicine
• Norman Bethune University of Medical Sciences in China, Neurology 

Key Publications

• Plass, C., Yu, F., Yu, L., Caligiuri, M. et al. (1999) Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene. Oncogene 18: 3159-3165
• Khatri, V., Fehniger, T., Baiocchi, R., Yu, F., Shah, M. et al. (1998) Ultra  low dose interleukin-2 therapy promotes a type 1 cytokine profile in vivo in patients with AIDS and AIDS-associated malignancies. J. Clin. Invest. 101: 1373-1378
• Caligiuri, M., Strout, M., Lawrence, D., Arthur, D., Baer, M., Yu. F.  et al. (1998) Rearrangement of ALL(MLL) in acute myeloid leukemia with normal cytogenetics. Cancer Research 58: 55-59
• Plass, C., Weichenhan, D., Catanese, J., Costello, J., Yu, F. et al. (1997) An arrayed human NotI-EcoRV boundary library as a tool for RLGS spot analysis. DNA research  4: 253-255
• Caligiuri, M., Strout, M., Oberkircher, A., Yu. F., Chapelle, A., Bloomfield, C.  (1997) The partial tandem duplication of ALL-1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome.  Proc. Natl. Acad. Sci. USA. 94: 3899-3902
• Greengage, S. J., Fujihara, K., Yu, F., Du, T., et al. (1997) Novel compound tetra-, dinucleotide microsatelitte polymorphism in the tumor necrosis factor/lymophotoxin locus.  Clinical and Diagnostic Laboratory Immunology  4: 79-84
• Fujihara, K., Itoyama, Y., Yu, F. and Goto, I. (1996) Antibody-dependent cellmediated cytotoxicity (ADCC) in HTLV-I associated myelopathy/tropical spastic paraphrases (HAM/TSP). J. Neurol.Sci. 142: 65-69
• Yu, F., Itoyama, Y., Kira, J., Fujihara, K., Kobayashi, T., Kitamoto, T., Suzumura, A., Yamamoto, N. and Goto, I.  (1994) TNF-b produced by human T lymphotropic virus type-1 infected cells influences the proliferation of human endothelial cells and fibroblasts. J. Immunol. 152: 5930-5938
• Fujihara, K., Itoyama, Y., Yu, F. and Goto, I. (1991) Cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). J. Neurol. Sci., 105: 99-107
• Yu, F., Itoyama, Y., Fujihara, K. and Goto, I. (1991) Natural killer (NK) cells in HTLV-1 associated myelopathy/tropical spastic paraparesis: Decrease in NK cell subset populations and activity in HTLV-1 seropositive individuals.  J. Neuroimmunology  33: 121-128 

Board Certification

• American Board of Family Medicine