James D. Mills, MD

Director, General and Preventive Cardiology

Dr. Mills is a board-certified cardiologist with subspecialty certifications in cardiovascular disease, cardiac computed tomography, nuclear cardiology, and echocardiography. He brings extensive clinical expertise in non-invasive multimodality imaging, preventive cardiology, and advanced structural cardiovascular imaging. A graduate of the West Virginia University School of Medicine (1991), Dr. Mills completed his internship (1992), residency (1994), and cardiovascular fellowship training (1997) at the University of Pittsburgh School of Medicine. Prior to joining RWJMS, he served as Associate Professor and Assistant Director for Stress and Metabolic Imaging at West Virginia University, where he contributed significantly to clinical care, education, and program development. At RWJMS, Dr. Mills leads the development of the Preventive Cardiology and Cardiac Genomic Programs, promoting a multidisciplinary approach to metabolic disease. He also provides expert clinical care in non-invasive multimodality imaging, including advanced structural cardiovascular imaging, and serves as an attending physician for both inpatient and outpatient cardiovascular services. Dr. Mills is deeply committed to medical education. His teaching portfolio spans foundational instruction for medical students in hypertension and electrocardiography to advanced fellowship training in nuclear cardiology and cardiac CT. He has mentored numerous medical students, residents, and fellows, earning recognition for excellence in teaching and mentorship. Originally from West Virginia, Dr. Mills is known for his sincerity, reliability, and compassionate approach to patient care. Outside of medicine, he has served as a coach and advisor for both men’s and women’s collegiate lacrosse teams, and he brings a grounded, team-oriented spirit to all aspects of his work.

1. Feuchtner GM, Lacaita PG, Bax JJ, Rodriguez F, Nakanishi R, Pontone G, Mushtaq S, Buechel RR, Gräni C, Patel AR, Singulane CC, Choi AD, Al-Mallah M, Andreini D, Karlsberg RP, Cho G, Rochitte CE, Alasnag M, Hamdan A, Cademartiri F, Maffei E, Marques H, Gonçalves Pereira PM, Gupta H, Hadamitzky M, Khalique O, Kalra D, Mills JD, Nurmohamed NS, Knaapen P, Budoff M, Shaikh K, Martin E, German DM, Ferencik M, Oehler AC, Deaño R, Nagpal P, Van Assen M, De Cecco CN, Foldyna B, Brendel JM, Cheng VY, Branch K, Bittencourt M, Bhatti S, Polsani V, Wesbey G, Cardoso R, Blankstein R, Delago A, Pursnani A, Alsaid A, Bloom S, Kamperidis V, Barbieri F, Aquino M, Danad I, van Rosendael A. AI-Quantitative CT Coronary Plaque Features Associate With a Higher Relative Risk in Women: CONFIRM2 Registry. Circ Cardiovasc Imaging. 2025 Jun;18(6):e018235. doi: 10.1161/CIRCIMAGING.125.018235. Epub 2025 Mar 31. PMID: 40162910; PMCID: PMC12173162.

2. Mahmoud A, Abdelsayed K, Mohamed AA, Najah Q, Abdulkader A, Ali K, Tabassum S, Abouzid MR, Abdelazeem B, Mills JD. Safety and efficacy of antisense oligonucleotides on triglyceride, apolipoprotein C-III, and other lipid parameters levels in hypertriglyceridemia; a network meta-analysis of randomized controlled trials. Lipids Health Dis. 2025 Mar 22;24(1):109. doi: 10.1186/s12944-024-02389-2. PMID: 40119340; PMCID: PMC11929262.