Edward Chuang, Ph.D.
Department of Molecular Biology and Biochemistry,
Nelson Labs, Piscataway, NJ
B.A. in Biochemistry and B.A. in Mathematics – Colby College, Waterville, ME
Ph.D. in Pharmacology – University of Pennsylvania, Philadelphia, PA
INSPIRE fellow, Department of Molecular Biology and Biochemistry – Rutgers University, New Brunswick, NJ
Research Mentor: Dr. Monica Driscoll, Ph.D.
My broad research interests are in cellular protein quality control pathways and how misfolded and aggregated proteins are sorted into various pathways of protein folding and degradation. I am currently exploring how various protein substrates are sorted into neuronal exophers for removal from the soma using C. elegans as a model organism.
Teaching Mentor: N/A
Teaching Interests: Chemistry, Biochemistry, and Molecular Biology
Jones, R.D., C. Enam, R. Ibarra, H.R. Borror, K.E. Mostoller, E.K. Fredrickson, J. Lin, E. Chuang, Z. March, J. Shorter, T. Ravid, G. Kleiger, and R.G. Gardner. (2020). The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate. Mol. Biol. Cell. 31(3):221-233.
Michalska, K.*, K. Zhang*, Z.M. March*, C. Hatzos-Skintges, G. Pintilie, L. Bigelow, L.M. Castellano, L.J. Miles, M.E. Jackrel, E. Chuang, R. Jedrzejczak, J. Shorter, W. Chiu, and A. Joachimiak. (2019). Structure of Calcarisporiella thermophila Hsp104 disaggregase that antagonizes diverse proteotoxic misfolding events. Structure. 27(3):4490463. (*Co-first author).
Chuang, E.*, A.M. Hori*, C.D. Hesketh*, and J. Shorter. (2018). Amyloid assembly and disassembly. J. Cell. Sci. doi: 10.1242/jcs.189928. (*Co-first author).
Gates, S.N*., A.L. Yokom*, J. Lin, M.E. Jackrel, A.N. Rizo, N.M. Kendsersky, C.E. Buell, E.A. Sweeny, K.L. Mack, E. Chuang, M.P. Torrente, M. Su, J. Shorter, and D.R. Southworth. (2017). Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 357(6348):273-279. (*Co-first author).
Torrente, M.P., E. Chuang, M.M. Noll, M.E. Jackrel, M.S. Go, and J. Shorter. (2016). Mechanistic insights into Hsp104 potentiation. J. Biol. Chem. 291(10):5101-5115.
Millard, J.T., E. Chuang, J.S. Lucas, E.E. Nagy, and G.T. Davis. (2013). Case-Study Investigation of Equine Maternity via PCR-RFLP: A Biochemistry Laboratory Experiment. J Chem Educ. 90(11). doi: 10.1021/ed300740r.