Current Fellows

Edward Chuang, Ph.D. Department of Molecular Biology and Biochemistry, Rutgers University Nelson Labs, Piscataway, NJ edward.chuang@rutgers.edu

Education

B.A. in Biochemistry and B.A. in Mathematics – Colby College, Waterville, ME

Ph.D. in Pharmacology – University of Pennsylvania, Philadelphia, PA

INSPIRE fellow, Department of Molecular Biology and Biochemistry – Rutgers University, New Brunswick, NJ

Research

Research Mentor: Dr. Monica Driscoll, Ph.D. 
 
My broad research interests are in cellular protein quality control pathways and how misfolded and aggregated proteins are sorted into various pathways of protein folding and degradation. I am currently exploring how various protein substrates are sorted into neuronal exophers for removal from the soma using C. elegans as a model organism.

Teaching

Teaching Mentor: N/A

 
Teaching Interests: Chemistry, Biochemistry, and Molecular Biology
 
Publications:
 

Jones, R.D., C. Enam, R. Ibarra, H.R. Borror, K.E. Mostoller, E.K. Fredrickson, J. Lin, E. Chuang, Z. March, J. Shorter, T. Ravid, G. Kleiger, and R.G. Gardner. (2020). The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate. Mol. Biol. Cell. 31(3):221-233.

Michalska, K.*, K. Zhang*, Z.M. March*, C. Hatzos-Skintges, G. Pintilie, L. Bigelow, L.M. Castellano, L.J. Miles, M.E. Jackrel, E. Chuang, R. Jedrzejczak, J. Shorter, W. Chiu, and A. Joachimiak. (2019). Structure of Calcarisporiella thermophila Hsp104 disaggregase that antagonizes diverse proteotoxic misfolding events. Structure. 27(3):4490463. (*Co-first author).

Chuang, E.*, A.M. Hori*, C.D. Hesketh*, and J. Shorter. (2018). Amyloid assembly and disassembly. J. Cell. Sci. doi: 10.1242/jcs.189928. (*Co-first author).

Gates, S.N*., A.L. Yokom*, J. Lin, M.E. Jackrel, A.N. Rizo, N.M. Kendsersky, C.E. Buell, E.A. Sweeny, K.L. Mack, E. Chuang, M.P. Torrente, M. Su, J. Shorter, and D.R. Southworth. (2017). Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 357(6348):273-279. (*Co-first author).

Torrente, M.P., E. Chuang, M.M. Noll, M.E. Jackrel, M.S. Go, and J. Shorter. (2016). Mechanistic insights into Hsp104 potentiation. J. Biol. Chem. 291(10):5101-5115.

Millard, J.T., E. Chuang, J.S. Lucas, E.E. Nagy, and G.T. Davis. (2013). Case-Study Investigation of Equine Maternity via PCR-RFLP: A Biochemistry Laboratory Experiment. J Chem Educ. 90(11). doi: 10.1021/ed300740r.