Current Fellows

Jennifer E. Fragale, Ph.D.

Brain Health Institute,
Rutgers University

School of Public Health, Piscataway, NJ


B.S. in Biology– Montclair State University, Montclair, NJ

Ph.D. in Neuroscience – Rutgers University, Newark, NJ

INSPIRE fellow, Brain Health Institute— Rutgers University, New Brunswick, NJ


Research Mentor: Gary Aston-Jones, Ph.D. 
My research focuses on the role of the orexin/hypocretin system in opioid addiction.



Wei Zhang, Ph.D., New Jersey City University

Teaching Interests: Psychology and Statistics

Fragale, J.E., James, M.H., Aston-Jones G. (2020). Intermittent self-administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system. Addiction Biology. e12946.

 James, M.H., Fragale, J.E., Aurora, R., Cooperman, N.A., Langleben, D.D., Aston-Jones, G.(2020). Repurposing the dual orexin receptor antagonist suvorexant for the treatment of opioid use disorder: Why sleep on this any longer?. Neuropsychopharmacology, 45(5), 717-719.

 Mohammadkhani, A.*, Fragale, J.E.*, Pantazis, C.B., Bowrey, H.E., James, M.H., Aston Jones, G. (2019). G. Orexin-1 receptor signaling in ventral pallidum regulates motivation for the opioid remifentanil. Journal of Neuroscience, 39(49), 9831-9840. *Authors contributed equally.

 Fragale, J.E., Pantazis, C.B., James, M.H., Aston-Jones, G. (2019). The role of orexin-1 receptor signaling in demand for the opioid fentanyl. Neuropsychopharmacology, 44, 1690–1697.

 Fragale, J.E., Beck, K.D., Pang, K.C. (2017). Use of the Exponential and Exponentiated Demand Equations to Assess the Behavioral Economics of Negative Reinforcement. Frontiers in Neuroscience, 11:77.

Fragale, J.E., Khariv, V., Gregor, D.M., Smith, I.M., Jiao, X., Elkabes, S., Servatius, R.J., Pang, K.C., Beck, K.D. (2016). Dysfunction in amygdala-prefrontal plasticity and extinction-resistant avoidance: A model for anxiety disorder vulnerability. Experimental neurology, 275(1), 59-68.

Catuzzi (Fragale), J.E., Beck, K.D. (2014). Anxiety vulnerability in women: a two-hit hypothesis. Experimental Neurology, 259, 75-80.