Faculty & Staff

Research Interests: Cellular and molecular mechanisms in traumatic brain injury

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Research Interests: Spinal cord injury; Traumatic brain injury: Neural plasticity

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Research Interests: circadian rhythm, translational control, neuropsychiatric disorders

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Research Interests: Gene and growth factor regulation of neurogenesis during mammalian brain development, with a focus on models of human neurodevelopmental disorders, including autism, schizophrenia and environmental teratogens.

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Research Interests: Regulation of brain development and repair with a focus on glial cells. 

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Research Interests: Human skeletal and dental growth and devlopment as well as best teaching practices for gross anatomy in medical school.  

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Research Interests: My research focuses on medical education. Areas include innovative approaches to teaching and assessment of Clinical Neuroanatomy, Evidence-based medicine and Mind-body Medicine.

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Research Interests: The main goal of the Manzini lab is to bridge the genetics and mechanisms of disease to identify genes that are essential for human cognition and to define the molecular mechanisms underlying neurodevelopmental disorders focusing on autism and neuromuscular disorders. We combine human genetics with molecular, cellular, and behavioral approaches in murine and zebrafish models to link human genetics to neuronal cell biology, intracellular signaling, and behavior. Our recent work aims to identify molecular mechanisms that could underlie sex bias in autism.

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Research Interests:

Role of the Hedgehog (Hh) pathway in central nervous system (CNS) development

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Research Interests:

Light and electron microscopy, glial cell interactions, neurotoxicity

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Research Interests:

Autism; iPSC models

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Research Interests:

Neural computation and circuit mechanisms of rapid associative learning in health and disease.

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Research Interests:

The major goal of our research is to develop regenerative therapies for human oligodendrocyte disorders such as leukodystrophies, multiple sclerosis, and white matter injury associated with premature birth. The lab takes two approaches to achieve the goal: 1) gaining fundamental knowledge in human brain development, and 2) engineering transplantable human oligodendrocytes.

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Research Interests:

Neural basis of motor action. Using advanced optics, such as multiphoton optogenetics and Imaging, to understand how neural activity gives rise to movement. 

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Research Interests:

Mechanisms of synaptic regulation: From stem cell to the brain

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Research Interests:

Synaptic mechanism of Parkinson's disease and coccaine addiction

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Research Interests:

Understanding the changes individual neurons undergo as the nervous system matures and determining how these changes contribute to age-dependent neurological diseases

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Research Interests:

Pedagogic principles and practices, anatomy, histology, embryology, inflammation and wound healing

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Research Interests:

Developmental neurobiology and endocrinology; genetic studies of systems controlling growth, metabolism, responses to analgesics, and adaptation to environmental stress

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Research Interests:

Molecular and cellular mechanisms controlling differentiation of neural stem cells and development of projection neurons in the cerebral cortex.

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Research Interests:

Physiology, structure and function of potassium channels, role of potassium channels in causing disease.   

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Research Interests:

Neurotrophic factors and neuropeptides in neuronal development, traumatic brain injury and mental disorders.

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Research Interests:

Changes in oxygen supply, consumption and blood brain barrier permeability during cerebral ischemia and reperfusion. Role of hypoxia inducible factor-1 and excitatory amino acids in this regard. Mechanisms to control cerebral oxygen consumption during autism.

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Research Interests:

Regulation of Dendritic Spine Morphogenesis and Synaptic Plasticity

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Research Interests:

Structural and molecular basis of synapse formation and connectivity in relation to autism spectrum disorders

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Research Interests:

Education in histology

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Research Interests:

Medical education and curriculum innovation

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