Research Interests: Gene and growth factor regulation of neurogenesis during mammalian brain development, with a focus on models of human neurodevelopmental disorders, including autism, schizophrenia and environmental teratogens.
Research Interests: My research focuses on medical education. Areas include innovative approaches to teaching and assessment of Clinical Neuroanatomy, Evidence-based medicine and Mind-body Medicine.
Research Interests: The main goal of the Manzini lab is to bridge the genetics and mechanisms of disease to identify genes that are essential for human cognition and to define the molecular mechanisms underlying neurodevelopmental disorders focusing on autism and neuromuscular disorders. We combine human genetics with molecular, cellular, and behavioral approaches in murine and zebrafish models to link human genetics to neuronal cell biology, intracellular signaling, and behavior. Our recent work aims to identify molecular mechanisms that could underlie sex bias in autism.
The major goal of our research is to develop regenerative therapies for human oligodendrocyte disorders such as leukodystrophies, multiple sclerosis, and white matter injury associated with premature birth. The lab takes two approaches to achieve the goal: 1) gaining fundamental knowledge in human brain development, and 2) engineering transplantable human oligodendrocytes.
Changes in oxygen supply, consumption and blood brain barrier permeability during cerebral ischemia and reperfusion. Role of hypoxia inducible factor-1 and excitatory amino acids in this regard. Mechanisms to control cerebral oxygen consumption during autism.
Structural and molecular basis of synapse formation and connectivity in relation to autism spectrum disorders
Education in histology