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Division of Hematology

Learn More About the Department of Medicine

  • Message from the Chief

  • Faculty

  • Clinical Services

  • Hemophilia Treatment Center

  • Gene Therapy for Inherited Blood Disorders 

  • Fellowship Program

  • Research

On This page
  • Welcome to the Division of Hematology

Welcome to the Division of Hematology

The Division of Hematology is dedicated to providing the highest quality advanced subspecialized hematology care in an academic medical school setting. Our practice strives to incorporate the latest in hematologic research and teaching into the care of patients with hematologic disorders.  The Division develops and provides clinical, academic, research, laboratory, and teaching programs through Rutgers Robert Wood Johnson Medical School, Rutgers Health, and its primary teaching hospital, Robert Wood Johnson University Hospital.

Hematology division faculty actively participate in teaching and training the next generation of Hematology subspecialists, Internal Medicine Program residents, as well as second-, third-, and fourth-year medical students. The Division offers a 3-year ACGME-accredited fellowship training program in Hematology and Medical Oncology through an integrated program in conjunction with Rutgers Cancer Institute of New Jersey and RWJ Barnabas Health.

Hematology Division faculty conduct a large number of research projects with federal, state, foundation, and industry grant funding support. This support enables the division to provide several specialized and statewide referral centers and programs – providing advanced subspecialized clinical care and specialized coagulation laboratory services for patients with hematologic disorders on an inpatient and outpatient basis.

We welcome you and encourage you to explore our Division!

Claire Philipp, MD
Professor of Medicine
Chief, Division of Hematology
Melvyn, Abraham, and Yetta Motolinsky Chair of Hematology
Department of Medicine

On This page
  • Our Faculty

Our Faculty

Meet the esteemed faculty within the Division of Hematology who offer invaluable expertise and guidance in leading-edge medical research and patient care.

  • View Our Provider Directory
On This page
  • Clinical Services

Clinical Services

The Division of Hematology provides comprehensive outpatient services for patients with a broad spectrum of non-malignant hematologic disorders within an academic medical center. We serve as a regional referral center for patients with complex and rare hematologic conditions, providing highly specialized care that integrates clinical expertise, advanced laboratory capabilities, multidisciplinary collaboration, education, and research.

The Division's inpatient service provides consultation and ongoing management of complex hematologic disorders across the medical center, including patients with bleeding and thrombotic complications, cytopenias, hemoglobinopathies, and complex coagulation abnormalities. The Division works closely with hospital-based teams to provide timely recommendations for diagnosis, treatment, anticoagulation, transfusion, and perioperative hemostatic management.

Conditions we treat:

  • White blood cell disorders
  • Quantitative platelet disorders including ITP
  • Red blood cell disorders including Anemia
  • Hemoglobinopathies including sickle cell disease and thalassemia
  • Iron metabolism disorders
  • Myeloproliferative disorders
  • Plasma cell disorders
  • Bleeding disorders
    • Hemophilia A and B
    • Von Willebrand Disease
    • Qualitative platelet disorders
    • Rare Bleeding disorders
  • Blood clotting disorders
    • Blood clots including venous thromboembolism
    • Inherited thrombophilia
    • Antiphospholipid Syndrome

Current Programs

  • New Jersey Regional Hemophilia Program
  • Pediatric Hemostasis and Thrombosis Program
  • Thrombosis Center
  • Women with Bleeding Disorders Program

Special Hemostasis Laboratory

The division’s clinical services are supported by an onsite specialized coagulation laboratory, which provides advanced hemostasis testing and facilitates the diagnosis and management of complex bleeding and thrombotic disorders. The close integration of specialized laboratory expertise with clinical care allows for rapid interpretation of challenging coagulation studies and coordinated management of patients with uncommon or diagnostically complex conditions.

On This page
  • Hemophilia Treatment Center

Hemophilia Treatment Center

The Rutgers Robert Wood Johnson Medical School NJ Regional Treatment Center (HTC) is part of a national network of treatment centers that provide comprehensive, multidisciplinary care to patients with bleeding and clotting disorders.   The Rutgers HTC serves patients throughout the entire state of New Jersey as well as the tri-state area and sees approximately one thousand patients each year.  Due to the fact that many bleeding disorders are inherited life-long conditions, patients are often seen throughout their lifetime.

 

At the Rutgers HTC, a multidisciplinary team including adult and pediatric hematologists and nurses, physical therapist, social worker and patient navigator provide complex care to patients, including:

  • Individualized care plans
  • Referrals to specialists as needed
  • Genetic counseling and testing, including family screening
  • Highly specialized hemostasis laboratory testing
  • Management of pregnancy, labor, delivery and post-partum care
  • Coordination of medical procedures and surgeries as well as hospital stays
  • Treatment with intravenous and subcutaneous medication for prevention of bleeding and clotting
  • Training in self-administration of medication
  • Psychosocial support & mental health screening
  • Educational programs for people with bleeding disorders
  • Dedicated patient navigator to assist with access to care and insurance issues

While the HTC is known as a center for comprehensive care for persons with hemophilia, a wide range of other bleeding disorders are also treated here such as von Willebrand disease, platelet defects, thrombotic disorders & other rare factor deficiencies. 

On This page
  • Gene Therapy for Inherited Blood Disorders

Gene Therapy for Inherited Blood Disorders

Advances in gene therapy are changing the treatment landscape for people living with inherited blood disorders. Our Division of Hematology offers expertise in the evaluation and management of patients who may be candidates for these innovative therapies.

Gene therapy is now available for certain inherited red blood cell (RBC) disorders, including sickle cell disease and transfusion-dependent beta thalassemia, as well as selected other inherited blood disorders such as hemophilia B. These treatments are designed to address the underlying genetic cause of disease and, for some patients, may offer the potential for a significant reduction in disease complications and the need for ongoing supportive treatments.

Determining whether gene therapy is appropriate is a highly individualized process. Our multidisciplinary team evaluates each patient’s diagnosis, medical history, disease severity, treatment history, and overall health to determine whether an approved gene therapy may be an option. We also provide counseling regarding the potential benefits, risks, treatment process, and long-term follow-up involved.

Our goal is to provide patients and families with access to the most advanced treatment options while ensuring that they receive comprehensive, coordinated care throughout the evaluation and treatment process.

If you or a family member has an inherited blood disorder, our team can help determine whether gene therapy or other advanced treatment options may be appropriate.

On This page
  • Details

Details

Advance Your Career

The Robert Wood Johnson Medical School/Rutgers Cancer Institute of New Jersey Hematology/Oncology Fellowship is an accredited three-year combined hematology and medical oncology fellowship training program.

Fellows can develop their teaching skills, under the supervision and mentorship of the attending faculty, in bedside teaching, small group, and conference presentations for medical students and internal medicine residents.

  • Learn More About Our Fellowship
On This page
  • Faculty Research Efforts

Faculty Research Efforts

Accordion Content

    • Screening for Bleeding Disorders in women with menorrhagia.
    • Elevated Factor VII as a risk factor for recurrent fetal loss
    • Association of intrauterine growth restriction with maternal and fetal hemostatic risk factors.
    • Role of a hemophilia treatment center in the management of women with menorrhagia.
    • Integration and Prevention Services for persons with bleeding and clotting disorders.
    • Management of Menorrhagia in women with bleeding disorders.
    • Universal Data and Serum Specimen Collection System for Hemophilia.
    • Platelet abnormalities in women with unexplained menorrhagia.
    • Recombinant antihemophilic factor without added human or animal protein: previously treated severe Hemophilia A.
    • Recombinant antihemophilic factor without added human or animal protein: severe Hemophilia A patients undergoing surgery.
    • Epidemiologic study of placental abruption.
    • Age and the Prevalence of Bleeding Disorders in women with menorrhagia.
    • Utility of bleeding time and platelet function analyzer in women with menorrhagia.
    • Open Label Study to Characterize the Safety and Efficacy of BDDrFVIII Manufactured by the Albumin Free Process (ReFacto AF) in the Treatment of Previously Treated Patients (PTP) with Severe Hemophilia A.
    • Open-Label Single Arm, Safety and Efficacy Study of Recombinant Human Factor IX (rFIX; BeneFIX®) in Children Less than 6 years of age with severe Hemophilia B.
    • Open Label, Safety and Efficacy Study of Recombinant Human Factor IX (rFIX; BeneFIX) in previously treated patients (PTPs) with Hemophilia B (FIX: C £ 2%).
    • NovoSeven® (rFVIIa) by Single Dose for Home Treatment of Joint Bleeds in Hemophilia Patients with Inhibitors: A Pilot, Double-Blind Study versus Standard Multiple Doses of Novoseven and Open-Label FEIBA®.
    • Philipp CS, Faiz A, Dowling NF, Beckman M, Owens S, Ayers C, Bachmann G.  Development of a screening tool for identifying women with menorrhagia for hemostatic evaluation.  Am J Obstetrics Gynecology, 2008; 198(2):163.e1-8.  PMID: 18226613
    • Strair RK, Gharibo G., Schaar D., Rubin A, Harrison J, Aisner J, Taber K, Li Shen, Dudek L., Lin H, Lin Y, Goodell L, Rabson A, Medina D.  Nuclear Factor- kappaB modulation in patients with AML undergoing induction chemotherapy for acute myelogenous leukemia Clin Cancer Research 2008 Vol 14(22); 7564-8.  PMID: 19010875
    • Chen-Deutsch X, Garay E, Zhang J, Harrison JS, and George P. Studzinski c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D.  Leukemia Research 2009; 33(10):1298-300.  PMID: 19339050
    • Kouides P, Byams V, Philipp C, Stein S, Heit J, Lukes A, Skerrette N, Dowling N, Evatt B, Miller C, Owens S, Kulkarni R.  Multisite management study of menorrhagia with abnormal laboratory hemostasis: a prospective crossover study of intranasal desmopressin and oral tranexamic acid.  British Journal of Haematology, 2009, 145(2) 212-220. PMID: 19236375
    • Rose S, Ali Y, Kumar A, Saidi P.  Deep venous thrombosis caused by congenital interruption of the inferior vena cava and hereditary thrombophilia. Am J Med Sci 2009; 337(1): 67–70.  PMID: 19002010
    • Warad D, Chitlur MB, Philipp CS. Platelet disorders in the adolescent female. In: Hematology in the Adolescent Female, Springer, 2020; 61-78. 
    • Guo S, Philipp C. Hematologic Changes and Special Issues in Pregnancy. In: Classical Hematology: Expert Clinical Review, 2nd edition, Springer Nature, 2023, submitted 
    • Neetu J. Jain, Ambarina S. Faiz, Pamela A. Ohman-Strickland, John C. Smulian and George G. Rhoads. Educational Attainment of Grandmothers and Preterm Birth in Grandchildren. Maternal and Child Heath Journal, 25(2):293-301, 2021
    • Faiz AS, Guo S, Kaveney A, Philipp CS. Risk of Venous a and Endocrine Therapy in Older Women with Breast Cancer in the United States. Blood Coagulation and Fibrinolysis, May 2021
    • Ambarina S. Faiz, Shuang Guo, Ashwin Sridharan, Yong Lin, Claire S. Philipp. Venous Thromboembolism and Acute Myeloid Leukemia: Risk Factors and Mortality in Elderly White, Black and Asian Patients. Blood Coagulation and Fibrinolysis, September 2023
    • Faiz AS, Sridharan A, Guo S, Lin Y, Philipp CS.; Risk factors and mortality associated with venous thromboembolism in the elderly US population with acute lymphocytic leukemia. Thrombosis Update. Epub 2024 Mar
    • Bruiners N, Guerrini V, Ukey R, Dikdan RJ, Yang JH, Mishra PK, Onyuka A, Handler D, Vieth J, Carayannopoulos M, Guo S, Pollen M, Pinter A, Tyagi S, Feingold D, Philipp C, Libutti SK, Gennaro ML. Longitudinal analysis of biologic correlates of COVID-19 resolution: case report. Front Med (Lausanne). 2022 Jun 15;9:915367. doi: 10.3389/fmed.2022.915367. eCollection 2022. PMID: 35783607
    • Bruiners N, Guerrini V, Ukey R, Dikdan R, Yang J, Mishra PK, Onyuka A, Handler D, Vieth J, Carayannopulos M, Guo S, Pollen M, Pinter A, Tyagi S, Feingold D, Philipp C, Libutti S, Gennaro ML. Biologic correlates of beneficial convalescent plasma therapy in a COVID-19 patient reveal disease resolution mechanisms. medRxiv [Preprint]. 2022 Feb 3:2022.02.03.22269612. doi: 10.1101/2022.02.03.22269612. PMID: 35132422
    • Fiocco C, Farooq F, and Kaveney A. Acute disseminated intravascular coagulation precipitated by 177Lu-Dotatate in metastatic midgut neuroendocrine tumor: a case report. Journal of Gastrointestinal Cancer. 2023 Feb 16.
    • Kaveney A, Philipp C, Prendergast N, Kane, I, and Schlesinger N. Muscular Hematomas and COVID-19: A Missed Diagnosis?: A Case Report. Annals of Short Reports and Clinical Images. Volume 3. Article 1024. 2021.
    • Viola AS, Drachtman R, Kaveney A, Sridharan A, Savage B, Delnevo C, Coups E, Porter J, Devine K. Feasiblity of Medical Student Mentors to Improve Transition in Sickle Cell Disease. J Pediatr Psychol. 2021 Jul 20;46(6):650-661.
    • Viola AS, Levonyan-Radloff K, Drachtman R, Porter J, Savage B, Kaveney A, Sridharan A, Delnevo C, Coups EJ, Devine KA. Understanding barriers to transition from pediatric to adult care among young adults with sickle cell disease to develop a transition mentor program. Clin Prac Pediatr Psychol. Vol 9(1), Mar 2021, 68-81.
    • Philipp CS, Faiz A, Byams V, Miller CH, Heit JA, Kouides PA, Kulkarni R, Lukes A, Stein SF.  Screening tool for bleeding disorders in women with menorrhagia:  evaluation in a prospective US multi-site cohort.  Blood 2008; 112: 1237 (Presented American Society Hematology, 2008)
    • Heit JA, Beckman M, Grant A, Key NS, Manco-Johnson MJ, Moll S, Bockenstedt P, Kulkarni R, Ortel TL, Philipp CS.  Venous thromboembolism (VTE) characteristics among white- and black-Americans:  a cross-sectional study.  Blood 2008; 112: 3831 (Presented American Society Hematology, 2008)
    • Rossova V, Zhang J, Khanin M, Pesakhov S, Shpilberg O, Harrison JS, Levi I, Rouvio 0, Studzinski GP, Danilenko M.  Plant polyphenols potentiate vitamin D-induced differentiation of myeloid leukemia cells: Role of the antioxidant effect and upregulation of VDR and RXR Cancer Research (2009) Presented at the Annual Meeting of the American Society for Cancer Research, April 2009)
    • Vergano S, Wang X, Harrison J.  Large granular lymphocyte leukemia and pure red cell aplasia in a patient with autoimmune polyglandular syndrome type 1.  (Presented at the American Association of Clinical Endocrinology, 2009

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